Navigation Links
Molecular biology of sleep apnea could lead to new treatments
Date:3/19/2008

pathway to fix itself or one that leads to self destruction. The cell makes that decision based on its initial health.

If a patient has sleep apnea with healthy cells, the cells will take the fix-it path. Then good things happen; the cell activates another molecule called eIF-2alpha, which turns on helpful molecules like anti-oxidants that degrade the misfolded proteins, explains Veasey.

However if cells are unhealthy to begin with, the PERK pathway can also turn on molecules that cause the cell to turn on itself and activate apoptosis or cell death. In this event, we predict that patients with sleep apnea may lose motor neurons, notes Veasey. Eventually sleep apnea could continue to worsen since the few remaining neurons are already stressed when gasping for air during sleep.

A drug called salubrinal does keep the eIF-2alpha path active, thereby preventing vulnerable cells from going down the cell-death path. But salubrinal is a double-edged sword: Just the right amount keeps the cell happy, but too much can shut down all protein synthesis, a highly toxic outcome.

The research team is now working on how to ramp up the eIF-2alpha path with changes in the mouse diet. This paper shows which pathways are important for treating sleep apnea, but well need to come up with therapies other than salubrinal, says Veasey. Ultimately if we can do healthy things that protect the endoplasmic reticula of cells, then sleep apnea wont be such an insult, not only to motor neurons, but neurons involved in cognition and alertness.


'/>"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
Source:Eurekalert

Page: 1 2

Related medicine news :

1. A new molecular zip code, and a new drug target for Huntingtons disease
2. New knock-out gene model provides molecular clues to breast cancer
3. Molecular probe paints cancer cells in living animals, Stanford researchers find
4. Story ideas from molecular & cellular proteomics
5. SNM seeks novel approaches to molecular imaging to showcase at annual meeting
6. SNM seeks novel approaches to molecular imaging to showcase at annual meeting
7. Molecular fingerprint of breast-cancer drug resistance can predict response to treatment
8. Molecular profiling can accurately predict survival in colon cancer patients
9. Xceed Molecular Names Fran Tuttle to Its Board of Trustees
10. Virginia G. Piper Charitable Trust and Flinn Foundation launch molecular diagnostics initiative
11. Xceed Molecular Launches Ziplex(R) Automated Gene-Expression System at the Association for Molecular Pathology, Booth 84/85
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/29/2014)... 30, 2014 Saint Luke’s Medical ... awarded the Patient-Centered Medical Home 2011 Level 3 ... for Quality Assurance. Only one out of four ... Level 2, or Level 3 recognition. , Patients ... Medical Home report faster access to their doctors, ...
(Date:7/29/2014)... VA (PRWEB) July 29, 2014 The ... members of the Deadliest Cancer Coalition, led advocacy efforts ... officials in the newly established Congressional Caucus on the Deadliest ... efforts, the caucus now features the following 20 members: , ... Eshoo (CA-18) – May 2, 2014, Rep. Zoe Lofgren (CA-19) ...
(Date:7/29/2014)... (PRWEB) July 29, 2014 The One Minute ... by Alison Freeman, an herbal medicine specialist. Alison Freeman wanted ... herpes condition. , People interested in finding out more ... and can download it, as it is currently available in ... variety of natural remedies and herbal medicine tips that can ...
(Date:7/29/2014)... Denver, Colorado (PRWEB) July 29, 2014 Daily ... program was created by a holistic nutritional and functional medicine ... way of overcoming this problem. , Karen suffered from leaky ... so much time to develop this unique treatment. , ... her method, with sufferers from all around the world. The ...
(Date:7/29/2014)... WA, Australia (PRWEB) July 30, 2014 ... regulation of medical devices have determined Nurse Call ... and international legislation, this requires all Nurse Call ... This regulatory practice improves patient safety, reduces clinical ... and private hospital based Corporate Risk and Clinical ...
Breaking Medicine News(10 mins):Health News:Saint Luke’s Medical Group Awarded Patient-Centered Medical Home 2011 Level 3 Recognition 2Health News:Mesothelioma Organization Works to Add Members to ‘Deadliest Cancer Caucus’ 2Health News:Mesothelioma Organization Works to Add Members to ‘Deadliest Cancer Caucus’ 3Health News:One Minute to Herpes Cure Review Reveals Simplest Herpes Treatment 2Health News:Leaky Gut Cure Review Reveals Karen Brimeyer’s Natural Way to Heal Leaky Gut 2Health News:NiQ Health Reveals the Extensive Use of Unregulated Medical Devices in Australian Hospitals 2Health News:NiQ Health Reveals the Extensive Use of Unregulated Medical Devices in Australian Hospitals 3Health News:NiQ Health Reveals the Extensive Use of Unregulated Medical Devices in Australian Hospitals 4
... ... of City Dental, offers lifetime teeth bleaching services to new patients , ... Los Angeles (PRWEB) February 22, 2010 -- Leading ... their Free Bleaching for Life services. New patients who visit Dr. Galina for an exam, ...
... ... ... , , , ... ...
... ... ... , ... WASHINGTON , Feb. 22 ...
... ... ... ... ...
... the Sahlgrenska Academy at the University of Gothenburg, Sweden ... the different genetic patterns of neuroblastoma, an aggressive form ... advances in the treatment of this malignant disease, which ... published in the respected scientific journal, Proceedings of ...
... a spotted plaice? Probably. However, marine biologist ,Helen Nilsson ... ,person to research the spotted insides of plaice. ... intricate pigmentation ,patterns, which they use for camouflage, communication, ... A study conducted by ,researchers at the Department of ...
Cached Medicine News:Health News:LA Dentist, Dr. Katherine Galina, Offers Free Bleaching for Life 2Health News:Statewide Poll: Pennsylvania Must Adequately Fund Senior Care Services 2Health News:Statewide Poll: Pennsylvania Must Adequately Fund Senior Care Services 3Health News:Pelosi Statement on President Obama's Health Insurance Reform Proposal 2Health News:International Merchant Advisors CEO Mel Roseman to Discuss New Medical Marijuana Clinics Live on CBS Radio Network's Big Biz Show February 22, 2010 at 1:40 pm PST 2Health News:International Merchant Advisors CEO Mel Roseman to Discuss New Medical Marijuana Clinics Live on CBS Radio Network's Big Biz Show February 22, 2010 at 1:40 pm PST 3Health News:International Merchant Advisors CEO Mel Roseman to Discuss New Medical Marijuana Clinics Live on CBS Radio Network's Big Biz Show February 22, 2010 at 1:40 pm PST 4Health News:New DNA technique leads to a breakthrough in child cancer research 2
(Date:7/29/2014)... 29, 2014 /PRNewswire-iReach/ -- MHG Medical Management Services, ... its Medical Equipment and X-ray Annual Inspection ... tailored to the cruise industry,s unique requirements.  MHG ... to propose that they should develop a new ... is intended to create standardized processes and raise ...
(Date:7/29/2014)...  Roche (SIX: RO, ROG; OTCQX: RHHBY) launched its ... 2014 Clinical Lab Expo today by unveiling two booths ... is partnering with customers to redefine the value of ... day that they,re looking for a partner to help ... and offices," said Jack Phillips , president and ...
(Date:7/29/2014)... 2014  Neurocrine Biosciences, Inc. (Nasdaq: NBIX ... second quarter 2014 financial results after the Nasdaq market ... host a live conference call and webcast to discuss ... morning, August 7, 2014 at 8:00 a.m. Eastern Time ... the live conference call by dialing 866-952-1907 (US) or ...
Breaking Medicine Technology:MHG Medical Management Services Aims to Change Cruise Industry Standard With New Equipment Maintenance Program 2Roche focuses on partnering with customers to redefine the value of the laboratory at the AACC 2014 Clinical Lab Expo 2Roche focuses on partnering with customers to redefine the value of the laboratory at the AACC 2014 Clinical Lab Expo 3Roche focuses on partnering with customers to redefine the value of the laboratory at the AACC 2014 Clinical Lab Expo 4Neurocrine Biosciences Announces Conference Call And Webcast To Report Second Quarter 2014 Financial Results 2
The Fluoroskan Ascent, a dedicated microplate fluorometer, offers high sensitivity for a wide variety of fluorometric applications....
... is a fixed wavelength fluorometer for ... emission. The spectral characteristics are specifically ... DNA using the standard Hoechst 33258 ... from the presence of protein, RNA, ...
The VICTOR² D fluorometer is suitable for clinical assays based on fluorescence or time-resolved fluorescence from a wide variety of plates....
Liquid, ready-to-use, bar-coded Olympus reagents are convenient, economical easy-to-use and reliable. This is one of 122 tests standardized for use on the Olympus AU400e, AU640e, AU2700, and AU5400 C...
Medicine Products: