Navigation Links
Molecular biology of sleep apnea could lead to new treatments
Date:3/19/2008

pathway to fix itself or one that leads to self destruction. The cell makes that decision based on its initial health.

If a patient has sleep apnea with healthy cells, the cells will take the fix-it path. Then good things happen; the cell activates another molecule called eIF-2alpha, which turns on helpful molecules like anti-oxidants that degrade the misfolded proteins, explains Veasey.

However if cells are unhealthy to begin with, the PERK pathway can also turn on molecules that cause the cell to turn on itself and activate apoptosis or cell death. In this event, we predict that patients with sleep apnea may lose motor neurons, notes Veasey. Eventually sleep apnea could continue to worsen since the few remaining neurons are already stressed when gasping for air during sleep.

A drug called salubrinal does keep the eIF-2alpha path active, thereby preventing vulnerable cells from going down the cell-death path. But salubrinal is a double-edged sword: Just the right amount keeps the cell happy, but too much can shut down all protein synthesis, a highly toxic outcome.

The research team is now working on how to ramp up the eIF-2alpha path with changes in the mouse diet. This paper shows which pathways are important for treating sleep apnea, but well need to come up with therapies other than salubrinal, says Veasey. Ultimately if we can do healthy things that protect the endoplasmic reticula of cells, then sleep apnea wont be such an insult, not only to motor neurons, but neurons involved in cognition and alertness.


'/>"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
Source:Eurekalert

0

GOOD

Page: 1 2

Related medicine news :

1. A new molecular zip code, and a new drug target for Huntingtons disease
2. New knock-out gene model provides molecular clues to breast cancer
3. Molecular probe paints cancer cells in living animals, Stanford researchers find
4. Story ideas from molecular & cellular proteomics
5. SNM seeks novel approaches to molecular imaging to showcase at annual meeting
6. SNM seeks novel approaches to molecular imaging to showcase at annual meeting
7. Molecular fingerprint of breast-cancer drug resistance can predict response to treatment
8. Molecular profiling can accurately predict survival in colon cancer patients
9. Xceed Molecular Names Fran Tuttle to Its Board of Trustees
10. Virginia G. Piper Charitable Trust and Flinn Foundation launch molecular diagnostics initiative
11. Xceed Molecular Launches Ziplex(R) Automated Gene-Expression System at the Association for Molecular Pathology, Booth 84/85
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/15/2009)... couples of reproductive age were evaluated, Italian study found ... of children born with cystic fibrosis decreases when screening ... increases, a new study finds. , CF neonatal screening ... for many years. Since the 1990s, the area has ... infants born with CF. , Two different CF carrier ...
(Date:12/15/2009)... The American Diabetes Association and the CDC have released some sobering ... the United States. Treadmill desks offer employers an effective means of ... ... AZ (Vocus) December 14, 2009 -- Rates of diabetes are climbing ... in obesity rates. Despite this rise the American Diabetes Association has ...
(Date:12/15/2009)... -- 4R Systems, Inc., a leading provider of ... retailers significantly increase profits by optimizing their inventory ... The Vitamin Shoppe has been utilizing the 4R ... DC inventory solutions have helped us drive significant ... the last two years," said Tony Truesdale, President ...
(Date:12/15/2009)... The new compact LifeSpan TR200 folding treadmill, ... ), was highly praised by treadmill review groups ... The compact TR200 folding treadmill received awards for Best ... $1000. ,, The compact LifeSpan TR200 treadmill is ... spaces. "This category buster is a very compact treadmill ...
(Date:12/15/2009)... A new study links chronic obstructive pulmonary disease, ... as sentinels to activate the body,s immune system. ... adds to growing awareness of the immune system,s role ... more than 12 million Americans with wheezing, shortness of ... is key if doctors are to find better ways ...
Breaking Medicine News(10 mins):Health News:Wider Adult Screening May Mean Fewer Children With Cystic Fibrosis 2Health News:TrekDesk: A Potentially Positive Impact on Diabetes & Obesity 2Health News:TrekDesk: A Potentially Positive Impact on Diabetes & Obesity 3Health News:4R's Profit Optimizing Inventory Solutions Helps The Vitamin Shoppe Drive Increased Productivity and Performance 2Health News:4R's Profit Optimizing Inventory Solutions Helps The Vitamin Shoppe Drive Increased Productivity and Performance 3Health News:4R's Profit Optimizing Inventory Solutions Helps The Vitamin Shoppe Drive Increased Productivity and Performance 4Health News:Treadmill Reviews Rate Compact LifeSpan Treadmill Best Treadmill 2Health News:Immune cell activity linked to worsening COPD 2Health News:Immune cell activity linked to worsening COPD 3
... Over Current Therapies, MARKHAM, Ontario, Nov. 6 ... novel vitamin D analog, CTA018, at the 2008,Annual ... in Philadelphia.,In preclinical models, CTA018 has demonstrated advantages ... and paricalcitol,(Zemplar(R)), the latter currently being the most ...
... 6 Spectrum Control, Inc.,(Nasdaq: SPEC ), ... and systems, announced today that its Microwave Business ... microwave integrated assembly used,in military tactical communication terminals. ... orders and releases under the program,expected periodically throughout ...
... be Web cast live, LAVAL, QC, Nov. 6 ... today that on Tuesday, November 11, Mr. Gary,Schmid, President ... wholly owned subsidiary of BELLUS Health, will present a ... and,Renshaw 10th Annual Healthcare Conference to be held at ...
... November 6, 2008Children born to mothers with pregnancy-related diabetes ... to a research team directed by Professor Ginette Dionne ... discovery are published in the most recent issue of ... compared the vocabulary and grammar skills of 221 children ...
... DALLAS, Nov. 6 TrailBlazer Health,Enterprises, LLC, one ... announced today that Gil R. Glover has been ... company., Based in Dallas, Texas, TrailBlazer Health ... Medicare and other government,programs. In 2007, TrailBlazer processed ...
... with a Focus on Fun, FORT WORTH, Texas, ... cheerleading program for girls and boys between the,ages of ... Gym of Fort Worth SW. With an,emphasis on fun, ... aspects of cheerleading, including sideline,cheers and chants, stunts and ...
Other Medicine News:Health News:Cytochroma Announces Positive Comparative Data on CTA018 in Chronic Kidney Disease Model 2Health News:Cytochroma Announces Positive Comparative Data on CTA018 in Chronic Kidney Disease Model 3Health News:Cytochroma Announces Positive Comparative Data on CTA018 in Chronic Kidney Disease Model 4Health News:Cytochroma Announces Positive Comparative Data on CTA018 in Chronic Kidney Disease Model 5Health News:Spectrum Control Receives $1.2 Million Order for Microwave Integrated Assemblies 2Health News:BELLUS Health to present at the Rodman and Renshaw 10th Annual Healthcare Conference 2Health News:Pregnancy diabetes doubles the risk of language delay in children 2Health News:TrailBlazer Health Enterprises Names New President, Chief Operating Officer 2Health News:The Little Gym of Fort Worth SW Introduces Kids' Cheerleading Program 2
(Date:12/15/2009)... At today,s regular meeting of the board ... LZ ), the board declared a regular quarterly dividend ... to holders of record at the close of business ... Corporation ,, The Lubrizol Corporation (NYSE: ... produces and supplies technologies that improve the quality and ...
(Date:12/15/2009)... Dec. 15 NxStage Medical, Inc. (Nasdaq: ... dialysis products, today announced that a group of ... be embarking on a week-long, conventional (non-dialysis) Caribbean ... The cruise, dubbed the "2010 Freedom Cruise: We,re ... Fla. on January 3, 2010 and returns on ...
(Date:12/15/2009)... Dec. 15 Varian Medical Systems (NYSE: ... results for first quarter of fiscal year 2010 following ... 2010. The news release will be followed by ... p.m. PT. The news release and a link ... the company website at: www.varian.com/investor . To ...
Breaking Medicine Technology:Lubrizol Declares Dividend 2Group of NxStage(R) Home Hemodialysis Patients to Take Caribbean Cruise with the System One(TM) 2Group of NxStage(R) Home Hemodialysis Patients to Take Caribbean Cruise with the System One(TM) 3Group of NxStage(R) Home Hemodialysis Patients to Take Caribbean Cruise with the System One(TM) 4Varian Medical Systems Schedules First Quarter FY2010 News Release and Conference Call 2Oxygen Biotherapeutics Inc Expands Board of Directors 14593 1Oxygen Biotherapeutics Inc Expands Board of Directors 14593 2Transdel Pharmaceuticals to Webcast Presentation at 4th Annual BIOCOM Investor Conference 5691 1Transdel Pharmaceuticals to Webcast Presentation at 4th Annual BIOCOM Investor Conference 5691 2Transdel Pharmaceuticals to Webcast Presentation at 4th Annual BIOCOM Investor Conference 5691 3AMD LASERS Announces Partnerships With Three Industry Leading Companies 5686 1
... (ACE) is an integral part of the ... Angiotensin II as well as the degradation ... types, ACE is primarily located in endothelial ... diagnostic parameter for sarcoidosis and myocardial infarction ...
... Insulin is the principal hormone responsible for the ... in the b-cells of the islets of Langerhans ... form C-peptide and insulin. Both are secreted ... The mature insulin molecule is comprised of two ...
Calcitonin EIA Bone and Mineral Metabolism 021-SDX017...
Anti-PR3 EIA Auto-Immune Markers 013-PR3-96 Proteinase...
Medicine Products: