Navigation Links
Molecular Cause of Breast Cancer Metastasis Discovered
Date:4/3/2008

Signaling events in tumor pave the way for lung invasion, study shows

THURSDAY, April 3 (HealthDay News) -- Certain cancers tend to spread to specific tissues, and now researchers have gained a molecular handle on how that happens.

Working with breast tumors, Joan Massague, chairman of the Cancer Biology and Genetics Program at Memorial Sloan-Kettering Cancer Center in New York City, and his colleagues discovered a signaling "relay" that enables the cancer to molecularly "soften" its target tissue -- the lung in this case -- allowing circulating breast cancer cells to pass through capillary walls and penetrate the lung.

"It provides a very nice mechanism for how breast cancer cells specifically get out of the circulation and into the lungs. Nobody knew how they did that before," said Karl Saxe, a scientific program director at the American Cancer Society.

The results were published in the April 4 issue of Cell.

Key to this study is a signaling molecule called TGF-beta. Early in cancer progression, TGF-beta acts as a tumor suppressor, inhibiting cancer growth. Later, it actually stimulates cancer progression and metastasis. Massague was interested in how tumors trigger this molecular dichotomy.

His team began by identifying a molecular signature, a pattern of gene expression of 153 genes that identifies tumors that are both expressing and responding to TGF-beta. They then applied that signature to hundreds of primary breast tumors.

While there was no apparent correlation between TGF-beta signaling and metastasis in breast cancers that also express the estrogen receptor, the team found that tumors that were estrogen receptor-negative were much more likely to metastasize to lung. No similar correlation was found for metastasis to the bone, liver or brain.

When the team then asked which of the genes in the signature was responsible for this selectivity, they identified a s
'/>"/>

Copyright©2008 ScoutNews,LLC.
All rights reserved  

Page: 1 2 3

Related medicine news :

1. A new molecular zip code, and a new drug target for Huntingtons disease
2. New knock-out gene model provides molecular clues to breast cancer
3. Molecular probe paints cancer cells in living animals, Stanford researchers find
4. Story ideas from molecular & cellular proteomics
5. SNM seeks novel approaches to molecular imaging to showcase at annual meeting
6. SNM seeks novel approaches to molecular imaging to showcase at annual meeting
7. Molecular fingerprint of breast-cancer drug resistance can predict response to treatment
8. Molecular profiling can accurately predict survival in colon cancer patients
9. Xceed Molecular Names Fran Tuttle to Its Board of Trustees
10. Virginia G. Piper Charitable Trust and Flinn Foundation launch molecular diagnostics initiative
11. Xceed Molecular Launches Ziplex(R) Automated Gene-Expression System at the Association for Molecular Pathology, Booth 84/85
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Molecular Cause of Breast Cancer Metastasis Discovered
(Date:7/13/2014)... Recently, iFitDress.com, one of the most famous ... collection of brown evening dresses for worldwide ... at discounted prices, up to 50% off. , ... they are carefully made according to most fashionable styles. ... also offers pretty accessories: wedding shoes, dancing shoes, sandals, ...
(Date:7/13/2014)... variations in the quality of care are the most ... varies widely between regions within Europe, according to the ... date, published in The Lancet Oncology . , ... cancers of the blood has increased over the past ... targeted drugs in the early 2000s such as rituximab ...
(Date:7/13/2014)... research in Nature Genetics identifies a ... that causes eosinophillic esophagitis (EoE), opening up potential ... food allergy. , EoE is a chronic ... triggered by allergic hypersensitivity to certain foods and ... cells called eosinophils (part of the body,s immune ...
(Date:7/13/2014)... (PRWEB) July 13, 2014 Victorian Hotel ... by promoting the rental of bikes for its "Cycle ... downtown Victorian Hotel to tour the area using a ... tax. Bicycle enthusiasts love to call Vancouver home, as ... for cycle travel and picturesque journeys through the countryside. ...
(Date:7/13/2014)... 2014 Advanced boilers are preferred ... amount of fossil fuels, produce high-capacity power, emit ... increased global warming and climate change concerns, many ... harmful gas emissions and pollutants coming from fossilfuel-based ... the global advance boilers market., The global power ...
Breaking Medicine News(10 mins):Health News:2014 Brown Evening Dresses Added To iFitDress.com 2Health News:The Lancet Oncology: Differences in treatment likely to be behind differing survival rates for blood cancers between regions within Europe 2Health News:The Lancet Oncology: Differences in treatment likely to be behind differing survival rates for blood cancers between regions within Europe 3Health News:Study finds cause of mysterious food allergy, suggests new treatment strategy 2Health News:Study finds cause of mysterious food allergy, suggests new treatment strategy 3Health News:Victorian Hotel Creates Excitement by Adding "Cycle the City" Bike Rentals for Its Vancouver Hotel Rooms 2Health News:North America Advanced Boilers Market is Expected to Reach $518.7billion by 2019 - New Report by MicroMarket Monitor 2Health News:North America Advanced Boilers Market is Expected to Reach $518.7billion by 2019 - New Report by MicroMarket Monitor 3
... Brain Center America,s New Neuroactive Exercise Bike Trains the Body and Brain ... ... Fitness centers are entering the next lap of their evolution with the ... body and the brain as a joint fitness program , Stephane Bergeron, ...
... Holdings Inc.,(OTC Bulletin Board: CLXS), a leading developer ... that their life science research,portal http://www.BiomedExperts.com ... in December has exploded to over 60,000 per ... , (Logo: ...
... Inc., the nation,s largest independent behavioral health care ... an agreement with CareIntegra to provide enhanced integrated ... product offerings. (Logo: http://www.newscom.com/cgi-bin/prnh/20090106/PH55551LOGO ... ValueOptions(R) will collaborate to develop and conduct a ...
... TV Teacher, LLC(TM) announces the,donation of their video-modeling programs ... Bronx, and Staten Island. , ... Ellis, a mother struggling to help her frustrated five-year-old ... an unsuccessful two years of,"traditional" therapy, she realized she ...
... Pharmaceutical,Inc. (Nasdaq: BMRN ) today announced that ... company update at the 27th,Annual J.P. Morgan Healthcare Conference ... a.m. PT. , Interested parties ... call,via the investor section of the BioMarin website, ...
... Jan. 7 Atlanta-based Billian Publishing, Inc.,owners of ... , (Logo: ... Porter Research was founded in 1989 just as ... of accelerated innovation. Since then, new,and established companies ...
Cached Medicine News:Health News:Neuroactive Bike: America's First And Only Mind-Body Fitness Equipment Used For The Ultimate Brain Fitness Gym Program Launched This Month At Lady Of America Fitness Center 2Health News:Neuroactive Bike: America's First And Only Mind-Body Fitness Equipment Used For The Ultimate Brain Fitness Gym Program Launched This Month At Lady Of America Fitness Center 3Health News:Neuroactive Bike: America's First And Only Mind-Body Fitness Equipment Used For The Ultimate Brain Fitness Gym Program Launched This Month At Lady Of America Fitness Center 4Health News:Collexis BiomedExperts Hits 80,000 Registered Users Within the First Year! 2Health News:Collexis BiomedExperts Hits 80,000 Registered Users Within the First Year! 3Health News:ValueOptions(R) Enters Agreement with CareIntegra to Provide Integrated Health Services 2Health News:New York Schools Receive Program for Children with Autism 2Health News:BioMarin to Present at the 27th Annual J.P. Morgan Healthcare Conference 2Health News:Billian Publishing, Inc. Announces Acquisition of Porter Research 2
(Date:7/11/2014)... 2014 Research and Markets  has announced ... 2014-2018" report to their offering. ... is a hollow needle commonly used with a syringe ... extract fluids from it. A hypodermic needle is used ... that cannot be ingested. Hypodermic needles are broadly classified ...
(Date:7/11/2014)... -- On Thursday, July 10, 2014, ... Jones Industrial Average finished the day 0.42% lower at 16,915.07, ... losses were broad based as eight out of ten sectors ... Sector Index ended the day at 711.88, down 0.02%, while ... Investor-Edge has initiated coverage on the following equities: Covidien PLC ...
(Date:7/11/2014)... , July 11, 2014  Veran Medical ... announced today the positive, cost-effective final results ... SPiNPerc™ procedure. The SPiNPerc endobronchial percutaneous biopsy ... percutaneous approach to biopsy when a traditional ... and physicians experience positive financial outcomes when ...
Breaking Medicine Technology:Global Hypodermic Needles Market 2014-2018: Key Vendors are Becton, Dickinson and Co, Covidien, Retractable Technologies and Terumo Corp. 2Global Hypodermic Needles Market 2014-2018: Key Vendors are Becton, Dickinson and Co, Covidien, Retractable Technologies and Terumo Corp. 3Health Care Equipment Equities Movers and Shakers -- Research on Covidien, Baxter, DexCom, and Boston Scientific 2Health Care Equipment Equities Movers and Shakers -- Research on Covidien, Baxter, DexCom, and Boston Scientific 3Health Care Equipment Equities Movers and Shakers -- Research on Covidien, Baxter, DexCom, and Boston Scientific 4Veran Medical Publishes Lung Cancer Patient Management Study 2
... OAK BROOK, Ill. , July 12 The University ... agreement to Ascent, a leader in health care resource sustainability. The agreement, ... 1, 2010 . Under the contract, Ascent will offer single-use device (SUD) ... , , , ...
... July 12 ( http://www.myprgenie.com ) -- Medrium, Inc., one ... announced it has signed a partnership agreement with RelayHealth to use ... LabCorp and to provide LabCorp results to physicians utilizing the Medrium ... , ...
Cached Medicine Technology:University HealthSystem Consortium Awards Single-Source Agreement to Ascent for Medical Device Reprocessing Services 2University HealthSystem Consortium Awards Single-Source Agreement to Ascent for Medical Device Reprocessing Services 3Medrium Partners With RelayHealth 2Medrium Partners With RelayHealth 3
CRP Liquid Conrtols level 3...
Therapeutic Drug Calibrator Series...
The IRN method used on the Dimension clinical chemistry system is an in vitro diagnostic test intended for the quantitative determination of iron in serum....
The AST method used on the Dimension clinical chemistry system is an in vitro diagnostic test intended for the quantitative determination of aspartate aminotransferase activity in serum or plasma...
Medicine Products: