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Molecular Breast Imaging Outperforms MRI for Patients With Inconclusive Results in the Diagnosis of Cancer
Date:12/3/2008

CHICAGO, Dec. 3 /PRNewswire/ -- Breast-Specific Gamma Imaging (BSGI) has equivalent sensitivity and better specificity than breast MRI in patients with inconclusive findings after mammography and ultrasound in the diagnosis of breast cancer, according to findings presented today at the annual meeting of the Radiological Society of North America (RSNA). BSGI is a molecular breast imaging technique used as an adjunctive tool to mammography that can identify lesions independent of tissue density.

"The purpose of this study was to compare MRI and BSGI in women with indeterminate findings after applying mammography and ultrasound. We found BSGI has virtually equal sensitivity and better specificity than breast MRI in the diagnosis of breast cancer," said Dr. Leora Lanzkowsky.

Dr. Leora Lanzkowsky, as Medical Director of the Eisenhower Medical Center in Rancho Mirage, CA and her colleagues conducted BSGI and breast MRI on patients with complex, inconclusive mammographic and/or ultrasonic findings. In their group of 48 patients with 63 abnormalities, BSGI and MRI yielded consistent results in 37 of these areas and were inconsistent in 26. MRI was inconclusive in a greater number of benign cases -- 10 versus three on BSGI. Overall, in this group of patients with difficult to diagnose breast findings, the sensitivity of BSGI and MRI was 96 percent and 88 percent respectively; specificity was 46 percent and 27 percent respectively.

The advantages of BSGI over MRI include ease of interpretation with fewer images generated, and better tolerance of the test by patients. In addition, BSGI can be used in all patients including those with ferromagnetic implants or renal insufficiency.

BSGI for the study was conducted using a Dilon 6800 Gamma Camera, a high-resolution, small field-of-view gamma camera, optimized to perform BSGI. With BSGI, the patient receives a pharmaceutical tracing agent that is absorbed by all the cells in the body. Due to their increased rate of metabolic activity, cancerous cells in the breast absorb a greater amount of the tracing agent than the normal surrounding tissue and generally appear as "hot spots" on the BSGI image.

"Both tests are good in detecting breast cancer with similar sensitivity for cancer. Along with benefits of cost-effectiveness and comfort, BSGI can be more helpful in excluding inconclusive MRI results. The use of BSGI in this group can result in fewer unnecessary MRI guided biopsies. The reassurance from a truly negative test, indicating that she does not have breast cancer, is priceless information for the patient," said Dr. Lanzkowsky. The work will continue at the Nevada Imaging Centers in Las Vegas, where a new state of the art breast center in association with a high risk clinic will incorporate the Breast specific gamma imaging technology with other state of the art technologies in the assessment of women with both moderate as well as high risk for the development of breast cancer.

About Dilon Technologies

Dilon Technologies Inc. is bringing innovative new medical imaging products to market. Dilon's cornerstone product, the Dilon 6800, is a high-resolution, small field-of-view gamma camera, optimized to perform BSGI, a molecular breast imaging procedure which images the metabolic activity of breast lesions through radiotracer uptake. Many leading medical centers around the country are now offering BSGI to their patients, including: Cornell University Medical Center, New York; George Washington University Medical Center, Washington, D.C.; and The Rose, Houston. For more information on Dilon Technologies please visit http://www.dilon.com.


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SOURCE Dilon Technologies Inc.
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