Navigation Links
Moffitt researchers identify unique immune gene signature across thousands of patients' solid tumors
Date:10/25/2012

Researchers at Moffitt Cancer Center have discovered a unique immune gene signature that can predict the presence of microscopic lymph node-like structures in metastatic melanoma. The presence of these immune structures, the researchers said, appears to be associated with better survival and may indicate the possibility of selecting patients for immunotherapy based solely on the immune-related makeup of their tumors as an approach to personalized medicine.

The study appears in Scientific Reports, a journal from Nature Publishing Group.

In this study, the researchers analyzed a 12-chemokine gene expression signature across nearly 15,000 distinct solid tumors of different types, including metastatic melanoma. Chemokines are powerful immune system molecules known to be important in lymph node formation and function during development. The 12-chemokine gene expression signature was found to remarkably predict the presence of microscopic lymph node-like structures within some melanomas and was also associated with better overall survival of these patients.

The researchers speculate that the lymph nodal structures they identified are active and playing an important positive role in a self-elicited (endogenous) anti-tumor response initially locally and then systemically. They also anticipate that their findings in melanoma may extend to other solid tumors, such as those of colorectal, lung and ovarian origin.

"We believe this gene expression signature reveals information on a unique anti-tumor response mechanism within the microenvironment of certain patient solid tumors, which may be their Achilles' heel to make them unusually responsive to immunotherapy and possibly lead to improved patient survival," explained the study's senior author, James J. Mul, Ph.D., associate center director of Translational Research at Moffitt.


'/>"/>
Contact: Kim Polacek
kim.polacek@moffitt.org
813-745-7408
H. Lee Moffitt Cancer Center & Research Institute
Source:Eurekalert

Page: 1

Related medicine news :

1. Moffitt researchers find cancer therapies affect cognitive functioning among breast cancer survivors
2. Moffitt Cancer Center researchers: Quality of life as important as quantity of life
3. Moffitt Cancer Center researchers working at frontiers of melanoma research
4. Moffitt researchers find adolescents with cancer concerned about their future reproductive health
5. Moffitt researcher publishes book on nutritional management of cancer treatment effects
6. Moffitt researcher awarded GE grant to develop tool to detect breast cancer metastasis genetic risks
7. Researchers creating designer lymph nodes based on Moffitts Total Cancer Care initiative
8. Moffitt Cancer Center researchers identify drivers of sarcoma growth and survival
9. Moffitt Cancer Center researchers develop and test new anti-cancer vaccine
10. Moffitt researcher, colleagues find success with new immune approach to fighting some cancers
11. Moffitt researchers: Darwins principles say cancer will always evolve to resist treatment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/18/2014)... Fraser University psychologists have made a brain-related discovery ... attention-deficit disorders. , This discovery opens up the ... or suppress a specific brain activity that the ... , The Journal of Neuroscience has ... John McDonald, an associate professor of psychology and ...
(Date:4/17/2014)... chronic inflammation in non-cancerous prostate tissue may have nearly ... those with no inflammation, according to results of a ... Kimmel Cancer Center. , The link between persistent inflammation ... high-grade prostate cancer those with a Gleason score ... the most aggressive and rapidly growing prostate cancers. , ...
(Date:4/17/2014)... of Experimental Biology and Medicine a ... and Paul Kenis in the Institute of Genomic ... of Illinois Urbana-Champaign describe their recent work on ... variety of cell functions including energy metabolism, signaling, ... in regulating normal cellular behavior, redox status has ...
(Date:4/17/2014)... biology team has created a new technology for ... could travel the body and selectively target cancer ... biological devices that monitor and modify human physiology ... However, no existing technology enabled bioengineers to build ... and respond in a customized fashion. , "The ...
(Date:4/17/2014)... one in five infants in the United States annually ... several months after birth. Research into probiotic use for ... April 1, 2014 issue of the British Medical ... "Probiotics and Infant Colic," concluding that the use of ... did not reduce crying or fussing in infants ...
Breaking Medicine News(10 mins):Health News:Scientists discover brain's anti-distraction system 2Health News:Chronic inflammation linked to 'high-grade' prostate cancer 2Health News:Chronic inflammation linked to 'high-grade' prostate cancer 3Health News:Live cell imaging reveals distinct alterations of subcellular glutathione potentials 2Health News:Building 'smart' cell-based therapies 2Health News:New study says probiotic use for infant colic is not effective in reducing symptoms 2
... , , ... personal injury attorney John David Hart has filed 29 lawsuits against ... Medtronic USA, Inc. and Medtronic Puerto Rico Operations Co., in connection ... fractures which could result in serious injury or death. , ...
... , , , ... today announced its first device, the ZOOM-100DC brain electrical activity ... U.S. Food and Drug Administration under section 510(k) of the ... electroencephalogram (EEG) device capable of recording and displaying EEG waveforms ...
... SCOTTSDALE, Ariz., Aug. 11 ... of interoperable workflow solutions that advance the quality and safety of ... e fe r ral , its portal-based ... a streamlined, patient-centric and highly accountable process for tracking referrals. ...
... , , HOUSTON, Aug. 11 ... on workers, compensation, has announced its recent network certification in the ... few to achieve this certification, which covers all 159 counties in ... to leading workers, compensation providers for third party administrators, managed care ...
... , , HERMOSA BEACH, Calif., ... Cancer (PADRES), a non-profit organization committed to improving the quality of life for ... Volleyball match as part of the 2009 AVP CROCS SLAM BUD ... . , , (Photo: http://www.newscom.com/cgi-bin/prnh/20090811/LA59829 ) , , ...
... National Non-profit Provides No ... ... know that cataracts are the leading cause of vision loss among adults 55 and ... cataract development. , , , , ,Moreover, a recent study out of the University of ...
Cached Medicine News:Health News:Texas Law Firm Files Multiple Suits Against Medtronic as Deadline Approaches 2Health News:BrainScope(TM) Receives FDA Clearance for Portable EEG Device 2Health News:BrainScope(TM) Receives FDA Clearance for Portable EEG Device 3Health News:Carefx's New Referral Management Solution Increases Hospital Referral Volume, Enhances Collaboration Among Specialists, PCPs and Patients 2Health News:Carefx's New Referral Management Solution Increases Hospital Referral Volume, Enhances Collaboration Among Specialists, PCPs and Patients 3Health News:Carefx's New Referral Management Solution Increases Hospital Referral Volume, Enhances Collaboration Among Specialists, PCPs and Patients 4Health News:Rockport Healthcare Group Continues to Grow Coverage Area With New Work Comp Network Certification in Georgia 2Health News:Kevin Nealon, Jordan Farmar, Walter Perez, Cristian de la Fuente and Other Celebrities Participated in Beach Volleyball Match for Children With Cancer 2Health News:Kevin Nealon, Jordan Farmar, Walter Perez, Cristian de la Fuente and Other Celebrities Participated in Beach Volleyball Match for Children With Cancer 3Health News:EyeCare America Works to Prevent Blindness Caused by Cataracts 2Health News:EyeCare America Works to Prevent Blindness Caused by Cataracts 3
(Date:1/14/2014)... , Jan. 14, 2014 Dynamic Healthcare Services, Inc. ... today that it acquired Progressive Home Medical Equipment, Inc. ("Progressive") ... 2014. The terms of the acquisition were not disclosed. ... ("DME") company providing a wide range of sleep, mobility, and ...
(Date:1/14/2014)... , Jan. 14, 2014 Animal Emergency Critical Care, a ... Leesburg, Virginia is the first in ... chamber. Dr. Susan M. Barnes , Medical ... Barnes and husband, Dr. Cole Taylor , are avid scuba ...
(Date:1/14/2014)... Jan. 14, 2014 NineSigma , Inc., the ... Innovation Leadership Summit , May 14-16, 2014 at ... Cleveland Ohio . This is ... committed to breakthrough achievements through open innovation. Participants will ...
Breaking Medicine Technology:Dynamic Healthcare Services Completes Progressive Home Medical Equipment of Clarion, PA Investment 2Dynamic Healthcare Services Completes Progressive Home Medical Equipment of Clarion, PA Investment 3Hyperbaric Veterinary Medicine (hvm) Announces Animal Emergency Critical Care Installs A Small Animal Hyperbaric Chamber 2Expect the Unexpected from Leading Global Innovators at NineSigma Leadership Summit, Sharing Winning Strategies to Advance Innovation 2Expect the Unexpected from Leading Global Innovators at NineSigma Leadership Summit, Sharing Winning Strategies to Advance Innovation 3Expect the Unexpected from Leading Global Innovators at NineSigma Leadership Summit, Sharing Winning Strategies to Advance Innovation 4
... Lead to More Effective Antibiotics Against ,Superbugs, ... College of Engineering may have discovered the path,toward ... that have developed resistance to common antibiotics. The,researchers ... occurring,in bacteria that opens to door to new ...
... Clinical ... WHIPPANY, N.J. and ATLANTA, Sept. 6 ... terms to acquire Zurich,Biostatistics, Inc. (ZBI). With the ... acquisition further strengthens,ISI,s Clinical Data Interchange Standards Consortium ...
Cached Medicine Technology:Boston University Biomedical Engineers Find Chink in Bacteria's Armor 2Boston University Biomedical Engineers Find Chink in Bacteria's Armor 3Image Solutions, Inc. Acquires Zurich Biostatistics, Inc. 2Image Solutions, Inc. Acquires Zurich Biostatistics, Inc. 3
... HIBICLENS bonds with ... a protective, germ-killing field. ... fast acting antimicrobial effect, ... irritation potential promotes compliance ...
... solution, allows the user to prep one ... in less than 2-minutes. It also utilizes ... surgical scrubbing and healthcare personnel handwashing. ACTIPREP ... provide a tacky surface for drapes to ...
... This multi-purpose topical gel contains 10% ... broad-spectrum germicidal action. As a pre-operative prep, ... pooling of prepping solutions under the patient, ... The Gel is also approved as a ...
... Scrub is a gentle and effective surgical ... dryness. Povidone Iodine is known to kill ... bacteria, fungi, viruses, protozoa and yeasts. It ... step in patient pre-operative prepping, as well ...
Medicine Products: