Navigation Links
Moffitt researchers find cutaneous human papillomavirus infection a risk factor for skin cancer
Date:7/2/2012

Researchers at Moffitt Cancer Center and colleagues at the University of South Florida, the German Cancer Research Center in Heidelberg, and the International Agency for Research on Cancer in Lyon, France, conducted a case control study and found associations between having antibodies to certain types of cutaneous human papillomavirus (HPV) and a kind of skin cancer called squamous cell carcinoma (SCC).

Their study, the first case-control study to investigate the association between SCC and cutaneous HPV types belonging to five different genera, appeared in a recent issue of Cancer Epidemiology, Biomarkers & Prevention, a journal published by the American Association for Cancer Research. The research was supported by a grant from the James and Esther King New Investigator grant through the Florida Department of Health and by the Miles for Moffitt Foundation Funds.

"Squamous cell carcinoma of the skin is the second most frequently occurring cancer among Caucasians in the United States, and the numbers of cases continue to rise," said study lead author Dana E. Rollison, Ph.D., Moffitt associate member, vice president and chief health information officer. "Risk factors for SCC include ultraviolet radiation exposure via the sun, older age, light skin and suppressed immune system."

According to the researchers, evidence has been emerging that cutaneous human papillomavirus infection (not the mucosal HPV infection that is associated with cervical cancers) may be an additional risk factor for SCC. Their study investigated antibodies to cutaneous HPV types in five different genera - alpha, beta, gamma, mu and nu - in blood samples from patients with SCC and a control group that did not have SCC.

The study was conducted using 173 SCC cases from a university dermatology clinic and 300 controls who screened negative for skin cancer. Tumor tissue from 159 SCC cases was tested for the presence of cutaneous HPV infection.

The researchers found that SCC was significantly associated with antibodies to HPV 10 in genus alpha and HPV types 8 and 17 in genus beta. Additional associations were found between antibodies to beta HPV types 5 and 24 when SCC cases with those same HPV types in their tumors were compared to controls.

"While our current study provides evidence for an association between genus-beta HPV and SCC, the exact mechanism by which the association exists is still unclear," explained Rollison.

Some researchers hypothesize that infection with the genus-beta HPV has an effect on the repair of DNA in sun-damaged skin, an effect that subsequently leads to an accumulation of mutations that could predispose people to SCC formation.

The study, Rollison said, was unique in that it measured cutaneous HPV types in five different genera and investigated correlations between cutaneous HPV antibodies in the blood and HPV infection in the tumor.

"We hope that this study, aimed at identifying the role of cutaneous HPV infection in SCC, will lead to improved knowledge about who is at risk for SCC and the development of new means of prevention," concluded Rollison and the researchers.


'/>"/>

Contact: Patty Kim
patty.kim@moffitt.org
813-745-7322
H. Lee Moffitt Cancer Center & Research Institute
Source:Eurekalert

Related medicine news :

1. Moffitt Cancer Center researchers test drug combinations to prevent graft vs. host disease
2. Sun exposure and cutaneous HPV infection found synergistic in skin cancers, Moffitt says
3. Myelodysplastic syndrome treated with deferasirox shows beneficial iron reduction, Moffitt says
4. Moffitt researchers: Darwins principles say cancer will always evolve to resist treatment
5. Moffitt researcher, colleagues find success with new immune approach to fighting some cancers
6. Moffitt Cancer Center researchers develop and test new anti-cancer vaccine
7. Moffitt Cancer Center researchers identify drivers of sarcoma growth and survival
8. Researchers creating designer lymph nodes based on Moffitts Total Cancer Care initiative
9. Moffitt researcher awarded GE grant to develop tool to detect breast cancer metastasis genetic risks
10. Moffitt researcher publishes book on nutritional management of cancer treatment effects
11. Moffitt researchers find adolescents with cancer concerned about their future reproductive health
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... The American Board of ... its next President and Chief Executive Officer, succeeding Dr. James C. Puffer upon his ... July 1, 2018 until Dr. Puffer’s retirement at the end of 2018. Upon assuming ...
(Date:10/13/2017)... ... 13, 2017 , ... Apple Rehab Shelton Lakes , which specializes in ... the facility as part of a disaster drill on October 3rd. , Apple Rehab ... City Emergency Manager, as well as the Connecticut Long Term Care Mutual Aid ...
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... Yisrayl Hawkins, ... week that explains one of the most popular and least understood books in the ... cryptic and puzzling descriptions that have baffled scholars for centuries. Many have tossed it ...
(Date:10/12/2017)... ... 12, 2017 , ... First Healthcare Compliance (FHC), an industry ... a range of technology and learning solutions at the 68th Annual American Healthcare ... be held October 14–18, 2017 at the Mandalay Bay Resort in Las Vegas, ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... The American ... Excellence to Carol Friedman, PhD, FACMI, during the Opening Session of AMIA’s Annual Symposium ... 8. , In honor of Morris F. Collen, a pioneer in the field of ...
Breaking Medicine News(10 mins):
(Date:9/25/2017)... , Sept. 25, 2017   Montrium ... Master File solutions, today—from the IQPC Trial Master ... , NL)—announced that EastHORN Clinical Services has ... clinical programs and TMF management. EastHORN, a leading ... eTMF platform to increase transparency to enable greater ...
(Date:9/23/2017)... Pa. , Sept. 22, 2017 Janssen ... a complete response letter from the U.S. Food and ... seeking approval of sirukumab for the treatment of moderately ... letter indicates additional clinical data are needed to further ... moderately to severely active RA. ...
(Date:9/22/2017)... , Sept. 22, 2017 AVACEN Medical (AVACEN) ... is now successfully helping those with the widespread pain ... Fibromyalgia diagnosed Amanda in Essex, England ... washing my hair, experiencing no sleep at all, tremendous ... spasm… I cannot recommend [the AVACEN 100] enough, how ...
Breaking Medicine Technology: