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Moffitt researchers find cutaneous human papillomavirus infection a risk factor for skin cancer
Date:7/2/2012

Researchers at Moffitt Cancer Center and colleagues at the University of South Florida, the German Cancer Research Center in Heidelberg, and the International Agency for Research on Cancer in Lyon, France, conducted a case control study and found associations between having antibodies to certain types of cutaneous human papillomavirus (HPV) and a kind of skin cancer called squamous cell carcinoma (SCC).

Their study, the first case-control study to investigate the association between SCC and cutaneous HPV types belonging to five different genera, appeared in a recent issue of Cancer Epidemiology, Biomarkers & Prevention, a journal published by the American Association for Cancer Research. The research was supported by a grant from the James and Esther King New Investigator grant through the Florida Department of Health and by the Miles for Moffitt Foundation Funds.

"Squamous cell carcinoma of the skin is the second most frequently occurring cancer among Caucasians in the United States, and the numbers of cases continue to rise," said study lead author Dana E. Rollison, Ph.D., Moffitt associate member, vice president and chief health information officer. "Risk factors for SCC include ultraviolet radiation exposure via the sun, older age, light skin and suppressed immune system."

According to the researchers, evidence has been emerging that cutaneous human papillomavirus infection (not the mucosal HPV infection that is associated with cervical cancers) may be an additional risk factor for SCC. Their study investigated antibodies to cutaneous HPV types in five different genera - alpha, beta, gamma, mu and nu - in blood samples from patients with SCC and a control group that did not have SCC.

The study was conducted using 173 SCC cases from a university dermatology clinic and 300 controls who screened negative for skin cancer. Tumor tissue from 159 SCC cases was tested for the presence of cutaneous HPV infection.


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Contact: Patty Kim
patty.kim@moffitt.org
813-745-7322
H. Lee Moffitt Cancer Center & Research Institute
Source:Eurekalert

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