Navigation Links
Moffitt researchers: Darwin's principles say cancer will always evolve to resist treatment
Date:6/21/2012

According to researchers at Moffitt Cancer Center, cancer is subject to the evolutionary processes laid out by Charles Darwin in his concept of natural selection. Natural selection was the process identified by Darwin by which nature selects certain physical attributes, or phenotypes, to pass on to offspring to better "fit" the organism to the environment.

As applied to cancer, natural selection, a key principle of modern biology, suggests that malignancies in distinct "microhabitats" promote the evolution of resistance to therapies. However, these same evolutionary principles of natural selection can be applied to successfully manage cancer, say Moffitt researchers who published an opinion piece in a recent issue of Nature Reviews Cancer.

"Understanding cancer as a disease starts with identifying crucial environmental forces and corresponding adaptive cellular strategies," said Robert A. Gatenby, M.D., chair of the Department of Diagnostic Imaging. "Cancer is driven by environmental selection forces that interact with individual cellular adaptive strategies."

Cancer cell development, like any natural selection (or Darwinian) process, is governed by environmental selection forces and cellular adaptive strategies, the authors wrote. Investigating cancer and its proliferation through genetic changes and ignoring the adaptive landscape is most likely futile. Under "selective pressure" of chemotherapy, in this case the "adaptive landscape," resistant populations of cancer cells invariably evolve.

The authors say that tumors can be thought of as "continents" populated by multiple cellular species that adapt to regional variations in environmental selection forces. Their strategy in offering this metaphor, they wrote, is to "integrate microenvironmental factors at work during cancer's progression" into the model of the evolution of cancer and, particularly, the evolution of drug resistance.

"Hundreds of mutations
'/>"/>

Contact: Patty Kim
patty.kim@moffitt.org
813-745-7322
H. Lee Moffitt Cancer Center & Research Institute
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Moffitt researchers find cancer therapies affect cognitive functioning among breast cancer survivors
2. Moffitt Cancer Center researchers: Quality of life as important as quantity of life
3. Moffitt Cancer Center researchers working at frontiers of melanoma research
4. Moffitt researchers find adolescents with cancer concerned about their future reproductive health
5. Moffitt researcher publishes book on nutritional management of cancer treatment effects
6. Moffitt researcher awarded GE grant to develop tool to detect breast cancer metastasis genetic risks
7. Researchers creating designer lymph nodes based on Moffitts Total Cancer Care initiative
8. Moffitt Cancer Center researchers identify drivers of sarcoma growth and survival
9. Moffitt Cancer Center researchers develop and test new anti-cancer vaccine
10. Moffitt researcher, colleagues find success with new immune approach to fighting some cancers
11. Study Suggests Vaccine May Help Kids With Brain Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/22/2014)... A new study of self-awareness by Kessler ... (MS) may be able to improve their self-awareness ... ahead of print on July 2 in ... Nancy D. Chiaravalloti & John DeLuca: Metacognitive knowledge ... doi: 10.3233/NRE-141113). Self-awareness is one,s ability to recognize ...
(Date:8/22/2014)... attained the distinguished Magnet hospital designation by the ... Considered the gold standard for nursing excellence, the ... professionalism. It is the top international credential for ... Newport Hospital was based on the hospital,s continued ... , "It is a privilege for us to ...
(Date:8/22/2014)... Counseling may do little to help young people with ... 66 studies that included nearly 18,000 people 25 and ... drinking problems. Participants in 49 studies attended a single ... the studies attended group sessions or a mix of ... motivational interviewing was used in the studies. This technique ...
(Date:8/22/2014)... treatments have become available for key subtypes of ... treatments can be pre-identified by looking for defined ... whose lung cancer is driven by rearrangement of ... drug crizotinib, which targets this abnormality. Many ongoing ... success by matching different drugs with specific subtypes ...
(Date:8/22/2014)... (PRWEB) August 22, 2014 ItsHot.com, a ... now offering 60-80% off on its range of beautiful ... the purchase of Gold Hearts 14K White Rose Gold ... a discount of 77%. Previously priced at $3,715.00, ... $859.00. The item code of this mesmerizing pendant embedded ...
Breaking Medicine News(10 mins):Health News:Kessler Foundation study of self-awareness in MS has implications for rehabilitation 2Health News:Newport Hospital receives nursing's highest credential for third time with Magnet recognition 2Health News:Counseling Does Little to Deter Youth Drinking, Review Finds 2Health News:Online screening for rare lung cancer subtypes opens door to new kind of clinical trial 2Health News:Online screening for rare lung cancer subtypes opens door to new kind of clinical trial 3Health News:Online screening for rare lung cancer subtypes opens door to new kind of clinical trial 4Health News:ItsHot.com Now Offers 60-80% Discount on its Striking Collection of Diamond Heart Pendants 2
... new study reveals that almost two-thirds of US ... life, but very few of them experience post-traumatic ... emotional resilience in children, but it also suggests that ... adults, said William Copeland of Duke University Medical Center, ...
... Mayfield Dairy Farms announced today that it is voluntarily recalling ... a code date of 4/11/08 and a UPC code ... contains peanuts, which are not listed on the label. No ... ,Some individuals with allergies to peanuts run the ...
... Higher Colon Cancer Risk in Uveal Melanoma Patients and ... by Frederick H. Davidorf, MD, during the Association ... Meeting in Fort Lauderdale, Fla. ,The presentation ... p.m. to 4:45 p.m. in Hall B/C of the ...
... brown widow spider, a cousin to the well-known black widow, ... ,It is belongs to a group that is officially ... referred to as "fiddleback" spiders or "violin" spiders because of ... (fused head and thorax). ,The spiders are generally ...
... to over 76.6 million people over the age of 60. ... ministry, the country has 76,622,321 persons aged 60 and above. ... Uttar Pradesh tops the chart with 11.6 million elderly. ... has 5.7 million, Bihar and Tamil Nadu have 5.5 million ...
... Ministry of External Affairs, informed the Lok Sabha today that ... passports. ,At first these passports will be ... the end of 2007. Based on the experience gained from this ... the ordinary category by the end of 2008. , ...
Cached Medicine News:Health News:Two-thirds of US Children Experience Trauma, but Recover Fast 2Health News:Louisiana Residents Warned Against Brown Recluse Spiders 2
(Date:8/22/2014)... 22, 2014  Landauer, Inc. (NYSE: LDR ... measurement and monitoring, outsourced medical physics services and high ... E. Saxelby , its President and Chief Executive Officer, ... Officer and as a member of the Board of ... be replaced on an interim basis by Michael ...
(Date:8/21/2014)... -- Vermillion, Inc. (NASDAQ: VRML ), a multivariate ... has appointed Holly B. Bauzon as Vice ... Bauzon has a proven track record in both increasing ... companies. She has more than 20 years of healthcare ... the position of Director, Lab Services Sales and Managed ...
(Date:8/21/2014)... , Aug. 21, 2014 /CNW/ - Eisai Limited is ... introduction of the first-of-its-kind comic book available in ... has been designed specifically to educate children and their parents ... Canada affecting more than 300,000 Canadians. Eisai is ... care (hhc) , in which the patient is central – ...
Breaking Medicine Technology:Landauer, Inc. Announces Executive Management Change 2Vermillion Appoints Holly B. Bauzon as VP of Sales and Managed Markets 2Eisai Pleased to Support Canadian Epilepsy Alliance Comic Book that Teaches Children About Epilepsy 2
... Pharmaceuticals International, Inc. (NYSE: VRX ) (TSX: ... Cephalon, Inc. (NASDAQ: CEPH): In a letter ... stated that it "is presently undertaking a review of ... is focused on maximizing Cephalon shareholder value."  We know ...
... Onyx Pharmaceuticals, Inc. (Nasdaq: ONXX ) today announced ... to discuss first quarter 2011 financial results, as well as ... at 8:00 a.m. Eastern Time (5:00 a.m. Pacific Time; 2:00 ... ended March 31, 2011 will be released earlier that day. ...
Cached Medicine Technology:Valeant Pharmaceuticals Responds to Cephalon Board's Letter 2Valeant Pharmaceuticals Responds to Cephalon Board's Letter 3Valeant Pharmaceuticals Responds to Cephalon Board's Letter 4Onyx Pharmaceuticals Announces First Quarter 2011 Financial Results Teleconference and Webcast 2
The CSV-1000ETDRS10% test face presents the standard ETDRS test at a contrast level of 10%. This test is widely used in clinical studies for the evaluation of refractive surgery and contact lenses....
... The CSV-1000S test face is widely used ... evaluation. This test presents standard visual acuity from ... (6 and 12 cycles/degree) and a real-world driver's ... cataract documentation as it provides a standard acuity ...
Contrast sensitivity testing, glare sensitivity testing and ETDRS acuity testing are provided in the self standardized CSV-1000 instrument. Patented photocell circuitry automatically monitors and cal...
... those involved with healthcare decisions to keep ... evidence in their field of interest - ... as the volume of evidence increases. Cochrane ... best single source available for continually updated ...
Medicine Products: