Navigation Links
Moffitt cancer center researchers find novel predictor for MDS progression risk
Date:9/12/2012

Researchers at Moffitt Cancer Center and colleagues have discovered that changes in the physical characteristics of the effector memory regulatory T cell can predict the progression risk of myelodysplastic syndromes (MDS) to acute myeloid leukemia. The finding could improve prognostication for patients with MDS and better inform therapeutic decision making.

The study published in the August issue of The Journal of Immunology.

Awareness of the condition increased earlier this year when ABC's "Good Morning America" co-anchor Robin Roberts announced that she is battling MDS. Formerly known as pre-leukemia, MDS is a collection of blood disorders. One in three patients with MDS develops bone marrow failure and progresses to acute myelogenous leukemia within the first few years after diagnosis.

MDS involves the ineffective production of blood cells in bone marrow and often leaves patients anemic and in need of frequent blood transfusions.

The disease may develop as the result of chemotherapy or radiation for cancer treatment or can be related to bone marrow failure resulting from frequent transfusions and subsequent iron overload. Because the body has no natural means to reduce iron that accumulates from repeated transfusions, a patient's organs can become overloaded with iron, leading to heart failure, liver injury, susceptibility to infection and other complications. Bone marrow transplantation may be necessary.

Seeking to understand more about the development of MDS, Moffitt researchers and their colleagues investigated aspects of the immune system, particularly the role of regulatory T cells, also known as Tregs. Tregs, said the researchers, are well-defined players in tumor immune invasion in solid tumors, but little is known about the role Tregs play in pre-malignant human diseases.

"We investigated a Treg subset called 'effector memory Tregs,' " said study senior author Pearlie K. Epling-Burnette, Ph
'/>"/>

Contact: Kim Polacek
kim.polacek@moffitt.org
813-745-7408
H. Lee Moffitt Cancer Center & Research Institute
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Moffitt researchers say race affect likelihood of finding suitable stem cell donor
2. Moffitt Cancer Center researchers study childhood melanoma characteristics
3. Moffitt Cancer Center researchers find acidic pH microenvironments in tumors aid tumor cell survival
4. Review finds some evidence for chemo brain in breast cancer survivors, Moffitt Cancer Center says
5. Moffitt Cancer Center researchers and colleagues identify PHF20, a regulator of gene P53
6. Moffitt Cancer Center melanoma expert reviews unique adverse events with newly approved drug
7. Moffitt Cancer Center researchers validate molecular signature to predict radiation therapy benefit
8. Moffitt Cancer Center researchers discover how cancer cells hijack a mechanism to grow
9. Attitudes toward outdoor smoking ban at moffitt Cancer Center evaluated
10. Moffitt Cancer Center researcher & colleagues test new drug for patients with neuroendocrine tumors
11. Moffitt Cancer Center researchers find potential key to new treatment for mantle cell lymphoma
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... Spine Guide has built a reputation for ... spinal health. Now, the e-health site will offer new ... back pain symptoms. Spine Guide specializes in three types ... spine surgery. , Some of the most common back ... pain radiating down the leg, inability to stand up ...
(Date:8/27/2014)... Beach, Florida (PRWEB) August 28, 2014 ... Kevin Harrington, Chairman of As Seen On TV, Inc., ... as “The Millionaire Maker”. as Excelerate attendees will learn ... and will have the ability to pitch to an ... World Renowned Business Experts and Millionaire Mentors directly to ...
(Date:8/27/2014)... When it comes to the bedroom, most homeowners want ... breaking the bank in the process. Regardless of whether individuals ... for the master bedroom or simply looking for something inexpensive ... during their Labor Day mattress promotion. , This Labor ... for the home, while enjoying free delivery. Beyond bringing the ...
(Date:8/27/2014)... San Diego, CA (PRWEB) August 27, 2014 ... homeowner insurance policies will now be easier for the ... home insurance prices that are promoted in all 50 ... http://quotespros.com/homeowners-insurance.html . , The different insurers that are ... have made it possible for adults to use the ...
(Date:8/27/2014)... August 27, 2014 Locating an approximate ... consumer to present personal information before rates would be ... that life insurance quotes are distributed online using its ... term plans that an adult has access to review ... U.S. companies. The system for quotation distribution built in ...
Breaking Medicine News(10 mins):Health News:Spine Guide Offering New Overview of Surgical Options For Back Pain 2Health News:Bedding Mart, Top Mattress Store in Broken Arrow Oklahoma, Announces a Huge Labor Day Sale 2Health News:Home Insurance Prices for All 50 States Now Supplied at Consumer Insurance Portal Online 2Health News:Life Insurance Quotes for Term Policies Now Found at Insurer Website Online 2
... Aug. 8 (HealthDay News) -- The most effective treatment for ... the continuous positive airway pressure (CPAP) machine, according to a ... mask while the patient sleeps. This treatment is highly effective ... according to the review of available evidence. However, side ...
... By Amanda Gardner HealthDay Reporter , MONDAY, Aug. ... who has cardiac catheterization to diagnose heart disease is found ... But in other hospitals, relatively few are found to have ... patients may be getting unnecessary procedures, according to a study ...
... (August 8, 2011) The use of Acute Care Emergency ... significant reductions in key patient measures, such as length of ... ED overcrowding), according to a study published in the August ... Surgeons . Emergency departments are a crucial point of access ...
... Prenatal pet exposure, a mother,s delivery mode and race are ... 2, according to a Henry Ford Hospital study. In a ... researchers found that babies who have indoor prenatal pet exposure have ... IgE, between birth and age 2. IgE is linked to the ...
... -- The discovery of a gene pattern that distinguishes highly ... may help improve treatment of bone cancer in children, according ... species that develops bone cancer spontaneously with any frequency. Dogs ... human and dog forms of bone cancer are very similar, ...
... have radical surgery at university hospitals can benefit from excellent ... death rates, according to research in the August issue of ... 2,287 patients who had radical cystectomy surgery, where the bladder ... The surgery was performed at eight Canadian academic centres between ...
Cached Medicine News:Health News:CPAP Therapy Most Effective for Sleep Apnea, Experts Say 2Health News:CPAP Therapy Most Effective for Sleep Apnea, Experts Say 3Health News:Hospitals Vary Widely in Rate of Heart Procedures: Study 2Health News:Hospitals Vary Widely in Rate of Heart Procedures: Study 3Health News:Urgent assessment in emergency departments can reduce surgical decision time and overcrowding 2Health News:Prenatal pet exposure, delivery mode, race are key factors in early allergy risk 2Health News:Study of Bone Cancer in Dogs May Improve Treatment in Kids 2Health News:Improved radical surgery techniques provide positive outcomes for bladder cancer patients 2
(Date:8/27/2014)... YORK , Aug. 27, 2014 ... new market research report is available ... Chinese Guidebook for Application and Approval ... Regulations to Practices (2014 Edition) ... Now, Chinese regulations ...
(Date:8/27/2014)... -- CVS Caremark (NYSE: CVS ) announced today ... MedStar Health, a leading health care system with ten ... Washington, DC , region, which will ... patients. Through this clinical affiliation, MedStar Health patients will ... chronic disease monitoring and wellness programs at CVS/pharmacy stores ...
(Date:8/27/2014)... 27, 2014 Amgen (NASDAQ: AMGN ... (FDA) has granted priority review designation for ivabradine for ... an oral drug that inhibits the I ... the body,s cardiac pacemaker. 1 Ivabradine works to ... contractility or ventricular repolarization. 1 Heart failure is ...
Breaking Medicine Technology:Latest Chinese Guidebook for Application and Approval of Imported Medical Device Registration: From Regulations to Practices (2014 Edition) 2Latest Chinese Guidebook for Application and Approval of Imported Medical Device Registration: From Regulations to Practices (2014 Edition) 3Latest Chinese Guidebook for Application and Approval of Imported Medical Device Registration: From Regulations to Practices (2014 Edition) 4Latest Chinese Guidebook for Application and Approval of Imported Medical Device Registration: From Regulations to Practices (2014 Edition) 5Latest Chinese Guidebook for Application and Approval of Imported Medical Device Registration: From Regulations to Practices (2014 Edition) 6Latest Chinese Guidebook for Application and Approval of Imported Medical Device Registration: From Regulations to Practices (2014 Edition) 7Latest Chinese Guidebook for Application and Approval of Imported Medical Device Registration: From Regulations to Practices (2014 Edition) 8Latest Chinese Guidebook for Application and Approval of Imported Medical Device Registration: From Regulations to Practices (2014 Edition) 9Latest Chinese Guidebook for Application and Approval of Imported Medical Device Registration: From Regulations to Practices (2014 Edition) 10CVS Caremark Announces New Clinical Affiliation with MedStar Health 2CVS Caremark Announces New Clinical Affiliation with MedStar Health 3FDA Grants Amgen Priority Review Designation For Ivabradine For The Treatment Of Chronic Heart Failure 2FDA Grants Amgen Priority Review Designation For Ivabradine For The Treatment Of Chronic Heart Failure 3FDA Grants Amgen Priority Review Designation For Ivabradine For The Treatment Of Chronic Heart Failure 4FDA Grants Amgen Priority Review Designation For Ivabradine For The Treatment Of Chronic Heart Failure 5FDA Grants Amgen Priority Review Designation For Ivabradine For The Treatment Of Chronic Heart Failure 6FDA Grants Amgen Priority Review Designation For Ivabradine For The Treatment Of Chronic Heart Failure 7
... 18, 2007 /PRNewswire-FirstCall/ -- Vical,Incorporated today announced that ... following interim analysis of data,from the first 41 ... an,angiogenesis product candidate using Vical's DNA delivery,technology. Based ... the trial had been achieved with statistical,significance and ...
... Primary Endpoint of Improvement in Overall,Survival, WESTMINSTER, ... Inc. today announced top line results from,ENRICH, ... Efaproxyn ,(efaproxiral) plus whole brain radiation therapy ... breast cancer. The study,failed to achieve its ...
Cached Medicine Technology:Vical Licensee AnGes MG Announces Positive Results of Phase 3,Angiogenesis Trial in Japan 2Vical Licensee AnGes MG Announces Positive Results of Phase 3,Angiogenesis Trial in Japan 3Vical Licensee AnGes MG Announces Positive Results of Phase 3,Angiogenesis Trial in Japan 4Vical Licensee AnGes MG Announces Positive Results of Phase 3,Angiogenesis Trial in Japan 5Allos Therapeutics Reports Results for Phase 3 Enrich Study of,Efaproxyn in Women With Brain Metastases Originating From Breast,Cancer 2Allos Therapeutics Reports Results for Phase 3 Enrich Study of,Efaproxyn in Women With Brain Metastases Originating From Breast,Cancer 3Allos Therapeutics Reports Results for Phase 3 Enrich Study of,Efaproxyn in Women With Brain Metastases Originating From Breast,Cancer 4Allos Therapeutics Reports Results for Phase 3 Enrich Study of,Efaproxyn in Women With Brain Metastases Originating From Breast,Cancer 5Allos Therapeutics Reports Results for Phase 3 Enrich Study of,Efaproxyn in Women With Brain Metastases Originating From Breast,Cancer 6
... monoclonal antibody based colorimetric test intended ... gonorrhoeae. The test requires less than ... heating or pretreatment. The test does ... cultures. GonoGen&trade II eliminates agglutination, guesswork, ...
... GonoGen™ is a monoclonal ... for the confirmatory identification of ... not require isolated, viable or ... specimen and two minute rotation, ...
Rapid Test Kit...
... a novel device for the growth ... and Neisseria meningitidis. This product ... is easily transportable as a self-contained ... and examine the growth of organisms ...
Medicine Products: