Navigation Links
Moffitt Cancer Center study validates activity of rare genetic variant in glioma
Date:7/2/2012

Researchers at Moffitt Cancer Center working with colleagues at three other institutions have validated a link between a rare genetic variant and the risk of glioma, the most common and lethal type of brain tumor. The validation study also uncovered an association between the same rare genetic variant and improved rates of survival for patients with glioma.

The study, the first to confirm a rare susceptibility variant in glioma, appeared in a recent issue of the Journal of Medical Genetics, a journal published by the British Medical Association.

"Glioma is a poorly understood cancer with high morbidity and devastating outcomes," said study lead author Kathleen M. Egan, Sc.D., interim program leader of Cancer Epidemiology and vice chair of the Department of Cancer Epidemiology. "However, the discovery of the association of the TP53 genetic variant rs78378222 with glioma provides new insights into these tumors and offers better prospects for identifying people at risk."

According to the authors, their study "genotyped' the single nucleotide polymorphism (SNP, or "snip") rs78378222 in TP53, an important tumor suppressor gene. The researchers said the SNP disrupts the TP53 signal and, because of its activity, has been linked to a variety of cancers. This study linked the presence of the rare form of rs78378222 to deadly glioma.

The researchers conducted a large, clinic-based, case-control study of individuals age 18 and older with a recent glioma diagnosis. A total of 566 glioma cases and 603 controls were genotyped for the rs78378222 variant.

Study results reveal that the odds of developing glioma were increased 3.5 times among the rare variant allele carriers. However, when researchers examined the impact of rs78378222 on survival, they found an approximately 50 percent reduction in death rates for those who were variant allele carriers.

"That the variant increased survival chances was an unexpect
'/>"/>

Contact: Patty Kim
patty.kim@moffitt.org
813-745-7322
H. Lee Moffitt Cancer Center & Research Institute
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Moffitt researchers find cutaneous human papillomavirus infection a risk factor for skin cancer
2. Moffitt Cancer Center researchers test drug combinations to prevent graft vs. host disease
3. Sun exposure and cutaneous HPV infection found synergistic in skin cancers, Moffitt says
4. Myelodysplastic syndrome treated with deferasirox shows beneficial iron reduction, Moffitt says
5. Moffitt researchers: Darwins principles say cancer will always evolve to resist treatment
6. Moffitt researcher, colleagues find success with new immune approach to fighting some cancers
7. Moffitt Cancer Center researchers develop and test new anti-cancer vaccine
8. Moffitt Cancer Center researchers identify drivers of sarcoma growth and survival
9. Researchers creating designer lymph nodes based on Moffitts Total Cancer Care initiative
10. Moffitt researcher awarded GE grant to develop tool to detect breast cancer metastasis genetic risks
11. Moffitt researcher publishes book on nutritional management of cancer treatment effects
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/31/2014)... life. The last stage, when two daughter cells split ... of cell biology in the Victorian era. For just ... this final step, when the dividing cell creates a ... to this process by those early biologists, cytokinesis, translates ... highly active and organized series of events. Scientists have ...
(Date:10/31/2014)... (PRCHN) at Case Western Reserve University School of ... million in federal grants awarded to improve community ... Disease Control and Prevention (CDC) renewed the PRCHN,s ... funds will support the center,s ongoing efforts in ... interventions that prevent and reduce chronic disease in ...
(Date:10/31/2014)... Daily Gossip writes in its Xtreme Fat Loss review ... fat loss program ever developed. It promises to provide users ... is no wonder after all that this has become the ... nutrition and workout fat loss program was created by Joel ... to the author of this fat loss system, the method ...
(Date:10/31/2014)... At the start of 2014, numerous ... carbon monoxide poisoning in their homes. Now, as 2015 ... family-owned, Missouri-based heating and cooling company is taking a ... start the home heating season with the assurance that ... Beginning Nov. 1, 2014, E and Q Heating and ...
(Date:10/31/2014)... 2014 Energy Textiles has recently added ... gear is now available online, and Energy Textile is ... Celliant infrared-active athletic gear over compression gear. , ... has been signed for Under Armour to provide team ... eight years. In light of this decision, Energy Textiles ...
Breaking Medicine News(10 mins):Health News:Cell division, minus the cells 2Health News:Cell division, minus the cells 3Health News:Case Western Reserve, Cuyahoga County, YMCA of greater Cleveland: Public health grants 2Health News:Case Western Reserve, Cuyahoga County, YMCA of greater Cleveland: Public health grants 3Health News:Xtreme Fat Loss Diet Review Reveals How to Transform Your Body in 25 Days 2Health News:Many Homeowners Missing Key Safety Risks with Home Heating;Missouri-based Company E and Q Announces New Safety Check 2Health News:Many Homeowners Missing Key Safety Risks with Home Heating;Missouri-based Company E and Q Announces New Safety Check 3Health News:Compression Gear--Is There a Better Alternative? 2Health News:Compression Gear--Is There a Better Alternative? 3Health News:Compression Gear--Is There a Better Alternative? 4
... care enhancement program for patients with multiple chronic ... patient/family communications and their knowledge of their patients, ... at the Johns Hopkins Bloomberg School of Public ... of Annals of Family Medicine , found ...
... NY JULY 20, 2010 TCT 2010 (Transcatheter ... technologies and practices in interventional cardiology that will directly ... (September 21-25 in Washington, DC), late breaking data from ... cardiology techniques, and the interactions and effectiveness of new ...
... during and after pregnancy were able to cut the incidence ... study published in the British Journal of Dermatology ... at the Norwegian University of Science and Technology (NTNU), compared ... to women who were given a placebo. Use of the ...
... Reinberg HealthDay Reporter , MONDAY, July 19 (HealthDay ... of developing persistent ringing in the ear -- a condition ... one U.S. ear specialist called the data used for the ... a connection between cell phone use and tinnitus. The ...
... , MONDAY, July 19 (HealthDay News) -- People in an Alabama ... in their bodies were much more likely to have high blood ... PCBs actually caused their hypertension. If a direct connection does ... exposed to PCBs, which were once used in many products but ...
... in HIV/AIDS (BC-CfE) published an important study today in ... reinforces the view that the benefits of highly active ... to significantly preventing the transmission and spread of HIV. ... HIV, HAART uses a combination of drugs to stop ...
Cached Medicine News:Health News:Guided Care improves physician satisfaction with patient/family communications 2Health News:TCT 2010 to have significant impact on interventional cardiology practices and patient care 2Health News:Probiotics use in mothers limits eczema in their babies 2Health News:Can Cell Phones Cause Another Kind of Ringing? 2Health News:Could PCBs Help Boost Blood Pressure? 2Health News:Could PCBs Help Boost Blood Pressure? 3Health News:HIV/AIDS treatment curbs spread of disease: UBC-BC CfE study 2Health News:HIV/AIDS treatment curbs spread of disease: UBC-BC CfE study 3
(Date:10/31/2014)... Oramed Pharmaceuticals Inc. (NASDAQCM: ... on the development of oral drug delivery systems, ... call to discuss the clinical results from its ... proprietary oral insulin capsules, to treat type 1 ... a.m. Eastern time. Shareholders and other ...
(Date:10/31/2014)... , October 31, 2014 ... Inc. (NASDAQ: NSPH ), Isis Pharmaceuticals Inc. ... HALO ), ACADIA Pharmaceuticals Inc. (NASDAQ: ... Free research on these five companies can be accessed ... 30, 2014, the NASDAQ Composite ended at 4,566.14, up ...
(Date:10/31/2014)... British Journal of Urology ... discuss "male orgasmic dysfunction" with their doctor prior to ... symptoms while preserving sexual function     ... a paper in the British Journal of Urology International ... discuss with their doctors the likely impact of treatment ...
Breaking Medicine Technology:Oramed to Report Key Top Line Results from U.S. Phase IIa Trial with Oral Insulin in Type 1 Diabetes 2Oramed to Report Key Top Line Results from U.S. Phase IIa Trial with Oral Insulin in Type 1 Diabetes 3Momentum Indicators for Biotech Stocks -- Nanosphere, Isis Pharma, Halozyme Therapeutics, ACADIA Pharma, and Synta Pharma 2Momentum Indicators for Biotech Stocks -- Nanosphere, Isis Pharma, Halozyme Therapeutics, ACADIA Pharma, and Synta Pharma 3Momentum Indicators for Biotech Stocks -- Nanosphere, Isis Pharma, Halozyme Therapeutics, ACADIA Pharma, and Synta Pharma 4Momentum Indicators for Biotech Stocks -- Nanosphere, Isis Pharma, Halozyme Therapeutics, ACADIA Pharma, and Synta Pharma 5Sexual Dysfunction No Longer Inevitable When Treating Enlarged Prostate 2
... Internacional, S.A.B. de C.V. (BMV: LAB) ("Genomma Lab" or ... September 30, 2009. All figures included herein were prepared ... Mexican pesos. Also, the following consolidated figures show the Company,s ... , 3Q09 Highlights (vs. 3Q08) , During ...
... 26 ATS Medical, Inc. (Nasdaq: ATSI ), manufacturer ... announced that it will release financial results for the third ... Monday, November 2, 2009. The Company will host a ... 5:00 p.m. Eastern Time (2:00 p.m. Pacific Time) to discuss ...
Cached Medicine Technology:Genomma Lab Internacional Announces Third Quarter 2009 Results 2Genomma Lab Internacional Announces Third Quarter 2009 Results 3ATS Medical Announces Third Quarter 2009 Earnings Release Date and Conference Call 2
... delivers a solid-state green laser ... and plugs into any standard ... and extreme portability, the unit ... Nidek Phaco Emulsification System CV-24000 ...
There are many reasons to choose the CardioGenesis 2000 Holmium:YAG Laser System for TMR in your hospital or medical facility. Among the first is the CardioGenesis commitment to deliver the highest q...
Total T3 EIA Thyroid Function 025-BC-1005...
... The anti-TG test kit is a ... microplate format. It is designed for the ... thyroglobulin (TG) in serum or plasma. The ... 1: Calibrators, controls and patient samples are ...
Medicine Products: