Navigation Links
Moffitt Cancer Center study validates activity of rare genetic variant in glioma
Date:7/2/2012

Researchers at Moffitt Cancer Center working with colleagues at three other institutions have validated a link between a rare genetic variant and the risk of glioma, the most common and lethal type of brain tumor. The validation study also uncovered an association between the same rare genetic variant and improved rates of survival for patients with glioma.

The study, the first to confirm a rare susceptibility variant in glioma, appeared in a recent issue of the Journal of Medical Genetics, a journal published by the British Medical Association.

"Glioma is a poorly understood cancer with high morbidity and devastating outcomes," said study lead author Kathleen M. Egan, Sc.D., interim program leader of Cancer Epidemiology and vice chair of the Department of Cancer Epidemiology. "However, the discovery of the association of the TP53 genetic variant rs78378222 with glioma provides new insights into these tumors and offers better prospects for identifying people at risk."

According to the authors, their study "genotyped' the single nucleotide polymorphism (SNP, or "snip") rs78378222 in TP53, an important tumor suppressor gene. The researchers said the SNP disrupts the TP53 signal and, because of its activity, has been linked to a variety of cancers. This study linked the presence of the rare form of rs78378222 to deadly glioma.

The researchers conducted a large, clinic-based, case-control study of individuals age 18 and older with a recent glioma diagnosis. A total of 566 glioma cases and 603 controls were genotyped for the rs78378222 variant.

Study results reveal that the odds of developing glioma were increased 3.5 times among the rare variant allele carriers. However, when researchers examined the impact of rs78378222 on survival, they found an approximately 50 percent reduction in death rates for those who were variant allele carriers.

"That the variant increased survival chances was an unexpect
'/>"/>

Contact: Patty Kim
patty.kim@moffitt.org
813-745-7322
H. Lee Moffitt Cancer Center & Research Institute
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Moffitt researchers find cutaneous human papillomavirus infection a risk factor for skin cancer
2. Moffitt Cancer Center researchers test drug combinations to prevent graft vs. host disease
3. Sun exposure and cutaneous HPV infection found synergistic in skin cancers, Moffitt says
4. Myelodysplastic syndrome treated with deferasirox shows beneficial iron reduction, Moffitt says
5. Moffitt researchers: Darwins principles say cancer will always evolve to resist treatment
6. Moffitt researcher, colleagues find success with new immune approach to fighting some cancers
7. Moffitt Cancer Center researchers develop and test new anti-cancer vaccine
8. Moffitt Cancer Center researchers identify drivers of sarcoma growth and survival
9. Researchers creating designer lymph nodes based on Moffitts Total Cancer Care initiative
10. Moffitt researcher awarded GE grant to develop tool to detect breast cancer metastasis genetic risks
11. Moffitt researcher publishes book on nutritional management of cancer treatment effects
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/23/2015)... May 23, 2015 On May 16, the ... The event was a 5k mud obstacle run that raised ... 2 million people worldwide, and the reason we participated was ... Chad Davis, owner of Farrell’s eXtreme Bodyshaping. “One-hundred percent of ... Society.” , The event was not only attended by eXtreme ...
(Date:5/23/2015)... 23, 2015 Add High-Quality prismatic refractions into ... Studios. , It's as simple as dragging and dropping footage ... tool for full effect. , Including over 80 stunning ... 5k sensors making this the ultimate bundle for adding prismatic ... in this package are movie files designed for Final Cut ...
(Date:5/22/2015)... The American College of Traditional Chinese ... They will hold a webinar on the updates of ... on Classical Chinese Medicine. , Webinar – First Professional ... the Dean of Clinical Education, will lead this webinar ... Doctorate program. ACTCM is currently developing this degree program ...
(Date:5/22/2015)... Following yesterday’s announcement that Ascenta Health ... health brand Nature’s Way, Marc St-Onge has affirmed his ... Skin is an integral part of the agreement with ... to further develop Ascenta Skin into a leading player ... a breakthrough, anti-aging skincare supplement featuring 6 active ingredients ...
(Date:5/22/2015)... Topsfield, MA (PRWEB) May 22, 2015 ... Keri Hart, MS/CCC, SLP, RAC-CT, CHHRP-QT, Vice President ... International, “A very important ‘language’ that impacts how ... International, the leader in long term care reimbursement, ... and education programs and talent management, launches a ...
Breaking Medicine News(10 mins):Health News:Farrell’s eXtreme Bodyshaping Team Runs through the Muck for MS 2Health News:Developers at Pixel Film Studios Release ProFlare 5K Prism for Final Cut Pro X. 2Health News:ACTCM Announces Upcoming June Events 2Health News:Ascenta Skin President Announces Plans to Grow Brand 2Health News:Harmony Healthcare International Takes the Lead in Launching ICD-10 Coding Transition in Post-Acute Care 2Health News:Harmony Healthcare International Takes the Lead in Launching ICD-10 Coding Transition in Post-Acute Care 3
... Va.The Society of Interventional Radiology Foundation recently received ... future scholarship fund for interventional radiology fellows to ... to advancing the clinical needs of interventional radiology ... pivotal basic and clinical trials research. "This ...
... SEPTEMBER 23, 2009 Late-breaking data from SPIRIT IV, ... the U.S., shows that an everolimus-eluting stent demonstrated enhanced ... native coronary artery lesions when compared to a paclitaxel-eluting ... achieved with drug-eluting stents without sacrificing safety. ...
... Recent studies conducted by Dr. Eric Blough and his ... the common pain reliever acetaminophen may help prevent age-associated ... how acetaminophen may affect the regulation of protein kinase ... role in regulation of cellular survival, proliferation and metabolism. ...
... growth in key industries and stall already-weak GDP growth in ... economist in the University of Alabama at Birmingham (UAB) School ... in the economy of many U.S. cities and communities," Bryce ... the virus, consumers and businesses may respond by restricting travel ...
... ... External services for pharmaceutical firms have shown consistent growth ... to proliferate. The global share of biotechnology services spending is in ... The range of high-quality external services available to pharma ranges from ...
... thinking difficulties reported by breast cancer survivors, researchers say ... save the lives of people with cancer, but new ... brain. , Many cancer patients who receive chemotherapy ... loss of memory and the ability to concentrate, and ...
Cached Medicine News:Health News:Society of Interventional Radiology Foundation receives $1 million legacy gift 2Health News:SPIRIT IV trial shows everolimus stent sets new standard for event-free survival 2Health News:Research shows safe dosages of common pain reliever may help prevent conditions related to aging 2Health News:Swine flu could wreak more havoc on US economy, says UAB economist 2Health News:Cambridge Healthtech Institute and Bio-IT World Launch a New eNewsletter: Pharma Services News 2Health News:After-Effects of Chemotherapy May Include Memory Problems 2
(Date:5/22/2015)...   InspireMD, Inc. (NYSE MKT: NSPR) ("InspireMD" or ... today announced that its CGuard TM Embolic Prevention System ... Piotr Musialek , at the EuroPCR conference ... . PARADIGM, an investigator-initiated P rospective evaluation ... D revascularization I n symptomatic and increased-risk asymptomatic ...
(Date:5/22/2015)... CITY, Calif. , May 22, 2015 ... pharmaceutical company focused on the development and commercialization of ... pain, today announced that interim chief executive officer ... Healthcare Conference and chief financial officer Tim Morris ... Conference. Details of the two presentations are as follows: ...
(Date:5/21/2015)... Research and Markets ( ... "Market Assessment of Respiratory Diagnostics in the ... offering. ,     (Logo: http://photos.prnewswire.com/prnh/20130307/600769) , ,This research service ... market in the United States ... service provides detailed analysis of the current and ...
Breaking Medicine Technology:InspireMD's CGuardTM Highlighted at Clinical Presentation at EuroPCR 2015 Conference 2InspireMD's CGuardTM Highlighted at Clinical Presentation at EuroPCR 2015 Conference 3InspireMD's CGuardTM Highlighted at Clinical Presentation at EuroPCR 2015 Conference 4AcelRx Pharmaceuticals to Present at Two Upcoming Investor Conferences In June 2United States and Europe Respiratory Diagnostics Market Assessment 2015 2
... Medicine the B.E.S.T,study conducted in Italy , “TAKEN ... CONTROLLED,SUCCESSFULLY” , Prof. Fabbri: “Daily drug useless for ... people”.,Chiesi’s commitment to pneumological research , MILAN, Italy, ... dose,of cortisone necessary for the control of mild ...
... is,accumulating that depression is a risk factor for ... Health Watch. A,recent study found that people ages ... serotonin reuptake inhibitors,(SSRIs) had double the rate of ... points to depression itself as a source,of endocrine ...
Cached Medicine Technology:Mild Asthma, a Revolutionary Therapy from Italian Research 2Mild Asthma, a Revolutionary Therapy from Italian Research 3Antidepressant Use May Boost Fracture Risk, From Harvard Women's,Health Watch 2
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: