Navigation Links
Moffitt Cancer Center researchers working at frontiers of melanoma research
Date:4/27/2012

At Moffitt Cancer Center, patients with stage III and IV unresectable melanoma are now routinely genetically profiled for several gene mutations, including the BRAF gene, a known driver oncogene for melanoma. Research has shown that mutations in the BRAF gene determine sensitivity or resistance to a class of drugs that are BRAF inhibitors.

"We have found that a large number of patients with melanoma who have the BRAF gene mutation quickly develop resistance to drugs that are BRAF inhibitors," said Jeffrey S. Weber, M.D., Ph.D., director of the Donald A. Adam Comprehensive Melanoma Research Center at Moffitt. "A recent approach in the melanoma research community is to find ways to overcome resistance to drugs we targeted to mutated BRAF."

At Moffitt, researchers have access to a large database of patient-donated tissues through Moffitt's Total Cancer Care program, a far-reaching design for care that includes building a biorepository of tumor samples for study and patient selection for clinical trials participation. By looking for patient genetic profiles for BRAF, Moffitt researchers are working at the frontiers of personalized medicine, which is the effort to match the right patient to the right drug.

According to Weber, although 50 percent of melanoma patients might have the BRAF mutation, the lack of other valid molecular targets for melanoma has "hampered efforts to individualize therapy."

That may have changed now that the U.S. Food and Drug Administration approved the drug Vemurafenib for melanoma patients who test positive for the BRAF mutation.

An international team of researchers, including those at Moffitt led by Weber, found that when tested in a phase II clinical trial, Vemurafenib was highly effective for patients with previously treated metastatic melanoma that had the BRAF mutation.

The study was published in a recent issue of The New England Journal of Medicine (366;8).

However
'/>"/>

Contact: Patty Kim
patty.kim@moffitt.org
813-745-7322
H. Lee Moffitt Cancer Center & Research Institute
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Moffitt Cancer Center and GLG Pharma, LLC sign licensing agreement to develop the next generation of targeted anti-cancer therapeutics
2. Moffitt Cancer Center and GLG Pharma LLC sign licensing agreement to develop the next generation of targeted anti-cancer therapeutics
3. Moffitt Cancer Center researchers use new tool to counter multiple myeloma drug resistance
4. Moffitt researchers find possible key to preventing chemotherapy resistance in ovarian cancer
5. Moffitt Cancer Center researchers find more clues to causes of breast cancer
6. Moffitt Cancer Center researchers find regulatory T-cell clue to help prevent GVHD
7. Moffitt Cancer Center researchers unravel biochemical factor important in tumor metastasis
8. Moffitt Cancer Center researchers find men less willing to be screened for cancer
9. Moffitt Cancer Center researchers find MK1775 active against sarcomas
10. Moffitt researchers will be strong participants in American Society of Hematology meeting
11. Moffitt Cancer Center researchers find potential target for treating metastatic cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/3/2015)... ... ... Dental practice in Los Angeles , Sunset Plaza Dental, is now ... health emergencies, such as broken arms or a heart attack, should be evaluated in ... during a dental emergency. This is important, because dental trauma is extremely common. More ...
(Date:8/3/2015)... ... 03, 2015 , ... The art of preparing and cooking food comes naturally ... a young age, Nasreen Zereshki was extremely eager to cook Persian cuisine. Now that ... from My Persian Kitchen with the world. , Since Americans tend to be undereducated ...
(Date:8/3/2015)... ... August 03, 2015 , ... Sensato and ... “Designing Secure Healthcare Systems” This three-day, highly interactive and immersive workshop, has ... with access to the tactics, techniques and practices required to design and develop ...
(Date:8/3/2015)... ... 03, 2015 , ... A July 9 article from USA Today ... according to the American Dental Association. According to a study by the American Dental ... million in a single year to 2.2 million a year. Dentists and ADA officials ...
(Date:8/3/2015)... Decatur, Illinois (PRWEB) , ... August 03, 2015 , ... ... (IBAM NA) effective July 31. , The acquisition includes all of IBAM NA’s ... the opportunity to have both, a robust regionally located business, as well as a ...
Breaking Medicine News(10 mins):Health News:Los Angeles Dental Practice, Sunset Plaza Dental, Now Offers Emergency Dental Services 2Health News:Los Angeles Dental Practice, Sunset Plaza Dental, Now Offers Emergency Dental Services 3Health News:Persian Cuisine: Colorful and Extremely Healthy 2Health News:Sensato and Divurgent are pleased to announce the development of it’s new program “Designing Secure Healthcare Systems” 2Health News:Sensato and Divurgent are pleased to announce the development of it’s new program “Designing Secure Healthcare Systems” 3Health News:Sensato and Divurgent are pleased to announce the development of it’s new program “Designing Secure Healthcare Systems” 4Health News:Los Angeles Periodontists Comment on Rising Dental Emergency Room Trips 2Health News:Los Angeles Periodontists Comment on Rising Dental Emergency Room Trips 3Health News:Illinois Health & Science Expands Nuclear Medicine Footprint With Purchase of IBA Molecular North America, Inc. 2
... RED BANK, New Jersey, BRUSSELS and MELBOURNE, January 30, ... over a century of expertise, the global leader in ... the web. The,new http://www.ansell.com website is now ... new Investor Centre. , The ...
... AHA says research looked at smoking bans, acute care, ... (HealthDay News) -- Studies on smoking bans, acute care ... childhood obesity were among the top 10 major advances ... to the American Heart Association. , "It,s always difficult ...
... sugary fare may be to blame, researchers say , , ... TV more than five hours a day are prone ... suggests. , The connection? Too much time spent watching ... food choices, University of Minnesota researchers say. , "Television ...
... the nation,s first and largest provider of outsourced medical ... announced today that it has appointed Carmen Fontanez to ... Payor Sales and Services. In her new role, ... operations that serve hundreds of health plans across the ...
... German . , More than half of ... agents, are glycoproteins, which means that they contain sugar ... homogeneous sugar component. With modern purification techniques, it is ... for systematic biomedical studies. Synthesis in the lab is ...
... LISLE, Ill., Jan. 30 SpineMark Corporation,a spinal ... to develop Spine Centers of Excellence, has entered ... quality spinal care at,cost effective rates through the ... solution, the Healthplace Surgery Benefit(TM). As a ...
Cached Medicine News:Health News:Ansell Limited Launching a New Global Website 2Health News:Top 10 Heart-Stroke Advances for 2008 2Health News:Top 10 Heart-Stroke Advances for 2008 3Health News:Adult Fast-Food Diets Tied to Too Much TV as Teen 2Health News:Adult Fast-Food Diets Tied to Too Much TV as Teen 3Health News:Access MediQuip Appoints Executive Vice President of Payor Sales and Services 2Health News:Enzyme with a sugar antenna 2Health News:SpineMark Partners With Healthplace America to Offer Access to Top Quality Spinal Care 2Health News:SpineMark Partners With Healthplace America to Offer Access to Top Quality Spinal Care 3Health News:SpineMark Partners With Healthplace America to Offer Access to Top Quality Spinal Care 4
(Date:8/3/2015)... FRANCISCO, Calif. , Aug. 3, 2015 /PRNewswire/ ... the treatment of cancer, today announced the promotion ... Debanjan Ray , who previously served ... management, has been promoted to senior vice president ... CytomX, Mr. Ray held positions as the vice ...
(Date:8/3/2015)... OSAKA, Japan and FLORHAM PARK, ... today announced that once-daily naldemedine met its primary and ... for the treatment of opioid-induced constipation (OIC) in adult ... oral, peripherally acting mu-opioid receptor antagonist (PAMORA). This is ... its primary and key secondary endpoints. Study ...
(Date:8/3/2015)... Inc. (PK:ECIA), a medical device company owning patented surgical ... invasive surgery, today announced financial results for its fiscal ... The Company posted quarterly net revenue of $2.454 ... or $(0.02) per share. These results compare to net ... $202 thousand, or $(0.02) per share, in the year-ago ...
Breaking Medicine Technology:CytomX Announces Management Team Promotions 2CytomX Announces Management Team Promotions 3Naldemedine Meets Primary Endpoint In Phase 3 Study For The Treatment Of Opioid-Induced Constipation 2Naldemedine Meets Primary Endpoint In Phase 3 Study For The Treatment Of Opioid-Induced Constipation 3Naldemedine Meets Primary Endpoint In Phase 3 Study For The Treatment Of Opioid-Induced Constipation 4Encision Reports First Quarter Fiscal Year 2016 Results 2Encision Reports First Quarter Fiscal Year 2016 Results 3Encision Reports First Quarter Fiscal Year 2016 Results 4Encision Reports First Quarter Fiscal Year 2016 Results 5
... , ST. LOUIS , Feb. 8 ... its first Stereotaxis Magnetic Navigation System in Taiwan at ... a Grand Opening event on January 26 that received ... been successfully performed using Stereotaxis at the hospital. , "All too ...
... Md. , Feb. 8 Novavax, Inc. (Nasdaq: ... to discontinue negotiations in its pursuit of the previously announced ... Novavax,s virus-like-particle (VLP)-based vaccines against influenza in the country of ... inability to agree on acceptable terms of the proposed collaboration ...
Cached Medicine Technology:Stereotaxis Installs First System in Taiwan 2Stereotaxis Installs First System in Taiwan 3Novavax Terminates Negotiations with ROVI Pharmaceuticals for Influenza Vaccine Collaboration 2Novavax Terminates Negotiations with ROVI Pharmaceuticals for Influenza Vaccine Collaboration 3Novavax Terminates Negotiations with ROVI Pharmaceuticals for Influenza Vaccine Collaboration 4
The Protract stem offers a press-fit option which will allow choice of standard or lateralized neck offsets while keeping a consistent leg length....
Performa cemented stem....
Porous foundation 480 series....
Porous foundation 440 series....
Medicine Products: