Navigation Links
Moffitt Cancer Center researchers working at frontiers of melanoma research
Date:4/27/2012

At Moffitt Cancer Center, patients with stage III and IV unresectable melanoma are now routinely genetically profiled for several gene mutations, including the BRAF gene, a known driver oncogene for melanoma. Research has shown that mutations in the BRAF gene determine sensitivity or resistance to a class of drugs that are BRAF inhibitors.

"We have found that a large number of patients with melanoma who have the BRAF gene mutation quickly develop resistance to drugs that are BRAF inhibitors," said Jeffrey S. Weber, M.D., Ph.D., director of the Donald A. Adam Comprehensive Melanoma Research Center at Moffitt. "A recent approach in the melanoma research community is to find ways to overcome resistance to drugs we targeted to mutated BRAF."

At Moffitt, researchers have access to a large database of patient-donated tissues through Moffitt's Total Cancer Care program, a far-reaching design for care that includes building a biorepository of tumor samples for study and patient selection for clinical trials participation. By looking for patient genetic profiles for BRAF, Moffitt researchers are working at the frontiers of personalized medicine, which is the effort to match the right patient to the right drug.

According to Weber, although 50 percent of melanoma patients might have the BRAF mutation, the lack of other valid molecular targets for melanoma has "hampered efforts to individualize therapy."

That may have changed now that the U.S. Food and Drug Administration approved the drug Vemurafenib for melanoma patients who test positive for the BRAF mutation.

An international team of researchers, including those at Moffitt led by Weber, found that when tested in a phase II clinical trial, Vemurafenib was highly effective for patients with previously treated metastatic melanoma that had the BRAF mutation.

The study was published in a recent issue of The New England Journal of Medicine (366;8).

However
'/>"/>

Contact: Patty Kim
patty.kim@moffitt.org
813-745-7322
H. Lee Moffitt Cancer Center & Research Institute
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Moffitt Cancer Center and GLG Pharma, LLC sign licensing agreement to develop the next generation of targeted anti-cancer therapeutics
2. Moffitt Cancer Center and GLG Pharma LLC sign licensing agreement to develop the next generation of targeted anti-cancer therapeutics
3. Moffitt Cancer Center researchers use new tool to counter multiple myeloma drug resistance
4. Moffitt researchers find possible key to preventing chemotherapy resistance in ovarian cancer
5. Moffitt Cancer Center researchers find more clues to causes of breast cancer
6. Moffitt Cancer Center researchers find regulatory T-cell clue to help prevent GVHD
7. Moffitt Cancer Center researchers unravel biochemical factor important in tumor metastasis
8. Moffitt Cancer Center researchers find men less willing to be screened for cancer
9. Moffitt Cancer Center researchers find MK1775 active against sarcomas
10. Moffitt researchers will be strong participants in American Society of Hematology meeting
11. Moffitt Cancer Center researchers find potential target for treating metastatic cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/20/2014)... 20, 2014 In its latest blog post, ... treatment program that gets clients off to a great start ... believe in, is highlighting an important and possibly life-changing – ... everyone who wants to understand the insidious nature of drug ... belief that drug abuse targets a certain socioeconomic group, such ...
(Date:8/20/2014)... Texas Medical Research Associates is looking for ... help test the effectiveness of a new drug looking to ... be eligible to participate in the study. , According to ... can lead to cardiovascular disease, the no. 1 cause of ... the risk of heart disease and stroke. People with high ...
(Date:8/20/2014)... sleep may wake up to worse consequences than nodding ... of being obese by age 21 was 20 percent ... of sleep a night, compared with their peers who ... Control and Prevention recommends nine to ten hours of ... of Public Health at Columbia University and the University ...
(Date:8/20/2014)... (PRWEB) August 20, 2014 According to ... on August 7 in the multicounty litigation (MCL) case ... RE DEPUY ASR HIP IMPLANTS LITIGATION; no. BER-L-3971-11), nearly ... have been dismissed without prejudice. The cases enumerated in ... of being resolved.” The Rottenstein Law Group LLP, a ...
(Date:8/20/2014)... BCC Research ( http://www.bccresearch.com ) ... AND DETECTORS: TECHNOLOGIES AND GLOBAL MARKETS , the ... to grow to $15.2 billion by 2019, with ... 15.9%. Increasing industrialization is driving significant growth ... expanding range of industrial applications such as military ...
Breaking Medicine News(10 mins):Health News:New A Forever Recovery Blog Post Reminds People that Drug Abuse Doesn’t Discriminate 2Health News:New A Forever Recovery Blog Post Reminds People that Drug Abuse Doesn’t Discriminate 3Health News:Texas Medical Research Associates Announce New Study 2Health News:Teen sleeplessness piles on risk for obesity 2Health News:350 NJ DePuy ASR Lawsuits Dismissed Pending Settlement Talks, Notes Rottenstein Law Group LLP 2Health News:Global Market for Photonic Sensors and Detectors to Reach $15.2 Billion in 2019 2Health News:Global Market for Photonic Sensors and Detectors to Reach $15.2 Billion in 2019 3
... The American Journal of Gastroenterology suggests that smoking may ... in those// who suffer from Crohn’s disease. Where the ... eventually require surgical treatment. ,“In patients who ... the small intestine, rather than the colon,” says study ...
... cold may cause uncommon ailments if neglected, specialists warn. // ... have always thought it is harmless. But specialists say it ... also negatively impact vision or cause harm to any part ... cases of chronic sinusitis because of unchecked pollution. Chronic sinus ...
... has been recommended for medical conditions such as endometriosis, ... choice for women who dislike menstruation or find it ... and is it a reasonable lifestyle choice, asks Paula ... ,Birth control options that reduce or eliminate periods ...
... new cancer research study that may be the ‘last best ... to discover the genetic and environmental factors that cause and ... aims to enroll a geographically and ethnically diverse group of ... pave the way for the next generation of American Cancer ...
... the counter (OTC) drugs can be highly addictive, warn two ... of dependency on OTC drugs is often forgotten, write Drs ... months, they describe seeing three patients with addictions to Nurofen ... started using the product for its approved indications, but their ...
... benefit from having a tonsillectomy in the short term, ... and any benefits have to be balanced against the ... small study of adults from Finland showed that tonsillectomy ... days, compared with watchful waiting. ,But despite ...
Cached Medicine News:Health News:A Cold Shoulder to Cold - At Your Risk 2Health News:Should Menstrual Suppression Be a Lifestyle Choice? 2Health News:American Cancer Society Launches Major New Study 2Health News:American Cancer Society Launches Major New Study 3Health News:Is It Worth Having Surgery to Remove Your Tonsils? 2
(Date:8/20/2014)... -- Reportlinker.com announces that a new market research ... Global Patient Scales Industry ... worldwide markets for Patient Scales in US$ Thousand ... & Baby Scales, Chair Scales, and Under Bed ... the US, Canada, Japan, Europe, Asia-Pacific, Latin America, ...
(Date:8/20/2014)... Phase I Trial of Plasma ... KalVista Pharmaceuticals ("KalVista"), an ophthalmology company with a ... it has begun a Phase I, First in Human, ... the treatment of DME. The study,s Principal Investigator is ... Joslin Diabetes Center; Harvard Medical School Department of Ophthalmology, ...
(Date:8/19/2014)... , Aug. 19, 2014  Northwest Biotherapeutics (NASDAQ: ... developing DCVax® personalized immune therapies for solid tumor cancers, ... announced last Thursday, August 14, 2014, has closed.  The ... convertible at $7.30 per share of common stock.  The ... to purchase up to an additional 30% of these ...
Breaking Medicine Technology:Global Patient Scales Industry 2Global Patient Scales Industry 3Global Patient Scales Industry 4Global Patient Scales Industry 5Global Patient Scales Industry 6Global Patient Scales Industry 7Global Patient Scales Industry 8Global Patient Scales Industry 9Global Patient Scales Industry 10Global Patient Scales Industry 11Global Patient Scales Industry 12Global Patient Scales Industry 13Global Patient Scales Industry 14Global Patient Scales Industry 15Global Patient Scales Industry 16Global Patient Scales Industry 17Global Patient Scales Industry 18Global Patient Scales Industry 19KalVista Pharmaceuticals Announces Start of Clinical Development for Novel Treatment for Diabetic Macular Edema 2KalVista Pharmaceuticals Announces Start of Clinical Development for Novel Treatment for Diabetic Macular Edema 3KalVista Pharmaceuticals Announces Start of Clinical Development for Novel Treatment for Diabetic Macular Edema 4NW BIO COMPLETES THE CLOSING OF ITS $17.5 MILLION CONVERTIBLE NOTE OFFERING 2NW BIO COMPLETES THE CLOSING OF ITS $17.5 MILLION CONVERTIBLE NOTE OFFERING 3
... contamination, which causes false ... Hydrophobic, nonwicking and self-sealing ... pass through these aerosol-resistant ... to tips with absorption ...
Inquire...
... Finntip Filters are ideal ... methods, or for any work ... They are designed for pipetting ... samples, and other. For applications ...
... Finntip Filters are ideal for ... or for any work where ... are designed for pipetting DNA/RNA ... and other. For applications requiring ...
Medicine Products: