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Moffitt Cancer Center researchers unravel biochemical factor important in tumor metastasis
Date:11/9/2011

TAMPA, Fla. -- A protein called "fascin" appears to play a critical transformation role in TGF beta mediated tumor metastasis, say researchers at Moffitt Cancer Center in Tampa, Fla., who published a study in a recent issue of the Journal of Biological Chemistry.

According to study corresponding author Shengyu Yang, Ph.D., of Moffitt's Comprehensive Melanoma Research Center and the Department of Tumor Biology, elevated Transforming Growth Factor beta in the tumor microenvironment may be responsible for fascin over-expression, which in turn can promote metastasis in some metastatic tumors.

TGF beta is a versatile cytokine involved in many physiological and pathological processes in adults and in the developing embryo, including cell growth, cell differentiation, cell death (apoptosis) and cellular homeostasis. TGF beta is best known as a tumor suppressor, exerting growth inhibitory roles in normal tissue and early stage tumors. However, many metastatic tumors are able to overcome the growth inhibition and secreted elevated levels of TGF beta to promote tumor metastasis. How TGF beta promotes metastasis is not completely understood. The authors suggested that fascin may be the key to understand the pro-metastasis function of TGF beta, as fascin knockdown almost completely abolished TGF beta induced tumor cell migration and invasion.

The researchers explained that fascin levels are low or not detected in normal tissues, but are highly elevated in malignant tumors. Also, high fascin expression is associated with poor prognosis. It has been clear for some time, they noted, that there is a causal role for fascin over-expression in tumor cell dissemination. However, the underlying mechanism for the elevation of fascin levels has not been clarified. Their analysis using cell culture- based assay and patient microarray data mining strongly suggests that elevated TGF beta levels in tumors lead to fascin overexpression, which in turn pro
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Contact: Ferdie De Vega
Ferdinand.DeVega@moffitt.org
813-745-7858
H. Lee Moffitt Cancer Center & Research Institute
Source:Eurekalert

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