Navigation Links
Moffitt Cancer Center researchers say 1 specific microrna promotes tumor growth and cancer spread

Researchers at Moffitt Cancer Center have determined that the overexpression of microRNA-155 (miR-155), a short, single strand of ribonucleic acid encoded by the miR-155 host gene, promotes the growth of blood vessels in tumors, tumor inflammation, and metastasis. As a therapeutic target, miR-155 could potentially provide a new avenue of treatment when targeted with drugs to suppress its activity.

The study was published in an online issue of Oncogene in January.

MiR-155, which plays an important role in various physiological and pathological processes, is considered an indicator of poor prognosis for breast cancer patients when it is overexpressed. Controlling miR-155 expression could inhibit malignant growth, said the researchers.

"Our study shows that miR-155 is a driver of new blood vessel growth in tumors," said study lead author Jin Q. Cheng, M.D., Ph.D., senior member of the Cancer Biology and Evolution Program at Moffitt. "It also plays a critical role in metastasis, especially in triple-negative breast cancer. This makes miR-155 both a prognostic marker and a potential therapeutic drug target."

According to the researchers, several studies show that miR-155 is frequently increased in various human malignancies, including breast, lung, pancreatic and colon cancers. It also regulates a number of cell processes, including growth, survival, migration and invasion. Their study demonstrates that miR-155 promotes new blood vessel growth in breast cancer by targeting a natural tumor suppressor called VHL, part of an important cancer pathway for a cascade of events.

"Further studies could provide insight into the role of miR-155 in inflammation that leads to tumor progression," noted the researchers, who found elevated miR-155 in triple-negative breast cancer, a form of breast cancer that does not express the genes for estrogen, progesterone and human epidermal growth factor receptors.

"Our findings are important for a number of reasons," Cheng said. "We have shown that miR-155 targets and downregulates the tumor suppressor VHL and that miR-155 contributes to tumor growth and spread. This makes miR-155 a critical therapeutic target in breast cancer."


Contact: Kim Polacek
H. Lee Moffitt Cancer Center & Research Institute

Related medicine news :

1. Moffitt researchers find cancer therapies affect cognitive functioning among breast cancer survivors
2. Moffitt Cancer Center researchers: Quality of life as important as quantity of life
3. Moffitt Cancer Center researchers working at frontiers of melanoma research
4. Moffitt researchers find adolescents with cancer concerned about their future reproductive health
5. Moffitt researcher publishes book on nutritional management of cancer treatment effects
6. Moffitt researcher awarded GE grant to develop tool to detect breast cancer metastasis genetic risks
7. Researchers creating designer lymph nodes based on Moffitts Total Cancer Care initiative
8. Moffitt Cancer Center researchers identify drivers of sarcoma growth and survival
9. Moffitt Cancer Center researchers develop and test new anti-cancer vaccine
10. Moffitt researcher, colleagues find success with new immune approach to fighting some cancers
11. Moffitt researchers: Darwins principles say cancer will always evolve to resist treatment
Post Your Comments:
(Date:10/12/2015)... ... 13, 2015 , ... Heroes in Recovery (HIR) is proud ... Recovery Network’s Moments of Change conference in West Palm Beach, Florida. Rob Waggener, ... Dean Dauphinais who exemplify the ideals of the Heroes in Recovery movement. , ...
(Date:10/12/2015)... ... ... North American Tool Corporation has been named Supplier of the Year by ... on October 4th. , Each year, IBC recognizes distributors and suppliers ... to expect from members of IBC’s marketing group. The recipient of the Supplier ...
(Date:10/12/2015)... ... ... winner of the “Check-In and Win a Vacation to Hawaii” Facebook contest at Gold’s ... “I didn’t believe I could win a free vacation simply by checking in on Facebook ... gym and invest in my own health – and now I’m going to Hawaii.” , ...
(Date:10/12/2015)... ... October 12, 2015 , ... Amerec , a leader in ... and skin care equipment, will be displaying custom sauna and steam room solutions at ... high-end resorts and spas as customers, SpaEquip is recognized for their ability to assist ...
(Date:10/12/2015)... ... October 12, 2015 , ... ... of hypnosis by individuals who lack professional education and clinical training in a ... public for a variety of purposes such as: losing weight, managing pain, or ...
Breaking Medicine News(10 mins):
(Date:10/12/2015)... Leadership of the National Association of Vision Care ... Aspasia Shappet , CEO of MESVision resumed her role as ... at its annual strategic planning meeting in Chicago ... the organization from May 2013 to May of this year. ... a result of the increased demands of his recent appointment ...
(Date:10/12/2015)... , Oct. 12, 2015 A new computer ... children can predict whether they will develop effective language ... to a study in the journal Brain and ... --> In the journal,s Oct. 12 online edition, ... computer program determines how specific regions of the brain ...
(Date:10/12/2015)... ) ... "Personalized Medicine, Targeted Therapeutics and Companion Diagnostic ... Industry Trends, Technologies, Participants, and Environment" ... ) has announced the addition of ... Companion Diagnostic Market to 2019 - Strategic ...
Breaking Medicine Technology: