Navigation Links
Moffitt Cancer Center researchers say 1 specific microrna promotes tumor growth and cancer spread
Date:4/3/2013

Researchers at Moffitt Cancer Center have determined that the overexpression of microRNA-155 (miR-155), a short, single strand of ribonucleic acid encoded by the miR-155 host gene, promotes the growth of blood vessels in tumors, tumor inflammation, and metastasis. As a therapeutic target, miR-155 could potentially provide a new avenue of treatment when targeted with drugs to suppress its activity.

The study was published in an online issue of Oncogene in January.

MiR-155, which plays an important role in various physiological and pathological processes, is considered an indicator of poor prognosis for breast cancer patients when it is overexpressed. Controlling miR-155 expression could inhibit malignant growth, said the researchers.

"Our study shows that miR-155 is a driver of new blood vessel growth in tumors," said study lead author Jin Q. Cheng, M.D., Ph.D., senior member of the Cancer Biology and Evolution Program at Moffitt. "It also plays a critical role in metastasis, especially in triple-negative breast cancer. This makes miR-155 both a prognostic marker and a potential therapeutic drug target."

According to the researchers, several studies show that miR-155 is frequently increased in various human malignancies, including breast, lung, pancreatic and colon cancers. It also regulates a number of cell processes, including growth, survival, migration and invasion. Their study demonstrates that miR-155 promotes new blood vessel growth in breast cancer by targeting a natural tumor suppressor called VHL, part of an important cancer pathway for a cascade of events.

"Further studies could provide insight into the role of miR-155 in inflammation that leads to tumor progression," noted the researchers, who found elevated miR-155 in triple-negative breast cancer, a form of breast cancer that does not express the genes for estrogen, progesterone and human epidermal growth factor receptors.

"Our findings
'/>"/>

Contact: Kim Polacek
kim.polacek@moffitt.org
813-745-7408
H. Lee Moffitt Cancer Center & Research Institute
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Moffitt researchers find cancer therapies affect cognitive functioning among breast cancer survivors
2. Moffitt Cancer Center researchers: Quality of life as important as quantity of life
3. Moffitt Cancer Center researchers working at frontiers of melanoma research
4. Moffitt researchers find adolescents with cancer concerned about their future reproductive health
5. Moffitt researcher publishes book on nutritional management of cancer treatment effects
6. Moffitt researcher awarded GE grant to develop tool to detect breast cancer metastasis genetic risks
7. Researchers creating designer lymph nodes based on Moffitts Total Cancer Care initiative
8. Moffitt Cancer Center researchers identify drivers of sarcoma growth and survival
9. Moffitt Cancer Center researchers develop and test new anti-cancer vaccine
10. Moffitt researcher, colleagues find success with new immune approach to fighting some cancers
11. Moffitt researchers: Darwins principles say cancer will always evolve to resist treatment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/22/2014)... By Maureen Salamon ... -- A crucial part of conventional in vitro fertilization (IVF) ... can instead take place in a device inside the vagina, ... Colombia contend that the device, called an INVOcell, might sharply ... could also make the technology more accessible to those who ...
(Date:10/22/2014)... HealthDay Reporter TUESDAY, Oct. 21, 2014 ... while working for NBC News in Liberia has cleared ... unit at Nebraska Medical Center in Omaha, where he had been ... A blood test confirmed by the U.S. Centers for Disease Control ... Providence, R.I., NBC News reported Tuesday night. "Recovering ...
(Date:10/20/2014)... October 20, 2014 Allegheny General Hospital’s ... that enables physicians to repair a damaged mitral valve ... MitraClip system, developed by Abbott Vascular , ... progressive and life-threatening condition in which the heart’s mitral ... flow backward from the heart’s left ventricle into the ...
(Date:10/20/2014)... 2014 Women’s health specialist, Dr. Amber ... Gynecology of Columbus, Inc., A Division of MaternOhio Clinical ... more than 100,000 patients annually. Dr. Murphy will provide ... stages of a women’s life. She is accepting new ... Westerville and Dublin. , Dr. Murphy offers a wide ...
(Date:10/20/2014)... (PRWEB) October 20, 2014 Zereana Jess-Huff, a ... Mrs. Maryland 2014 on a platform to think outside the ... and uses her position to raise awareness about women’s other ... for breast cancer. You say the color pink and everybody ... know for a fact that it has not been won ...
Breaking Medicine News(10 mins):Health News:Experimental Infertility Treatment Seems Effective, Cheaper 2Health News:Experimental Infertility Treatment Seems Effective, Cheaper 3Health News:Experimental Infertility Treatment Seems Effective, Cheaper 4Health News:U.S. Cameraman Treated for Ebola 'Free' of the Virus 2Health News:U.S. Cameraman Treated for Ebola 'Free' of the Virus 3Health News:Allegheny General Hospital Introduces New, Beating-Heart Procedure for Mitral Valve Repair 2Health News:Allegheny General Hospital Introduces New, Beating-Heart Procedure for Mitral Valve Repair 3Health News:OhioHealth Welcomes New Women’s Health Specialist to MaternOhio Specialists in Obstetrics & Gynecology of Columbus, Inc. 2Health News:OhioHealth Welcomes New Women’s Health Specialist to MaternOhio Specialists in Obstetrics & Gynecology of Columbus, Inc. 3Health News:Ovarian Cancer Survivor Mrs. Maryland Urges Media to Think Outside the Bra 2Health News:Ovarian Cancer Survivor Mrs. Maryland Urges Media to Think Outside the Bra 3
... of Cost-Effective High-Quality Home Infusion Can be ... WASHINGTON, March 5 Patients on Medicare ... Johnny Isakson (R-GA) and Representative Eliot L. ... a flaw in the Medicare program which ...
... YORK (March 5, 2009) -- Two highly lethal viruses that ... established drug used to prevent and treat malaria, according to ... Medical College in the Journal of Virology . Due ... advance of the first April print issue. , The two ...
... of Nutrition and Physical Activity at the Indiana State ... GoTrybe.com to provide Indiana kids and teens with a ... fun. Young Hoosiers can enjoy FREE memberships to the ... www.GoTrybeIN.com . A 2007 Youth Risk Behavior Survey showed ...
... the commercial printing superstore was honored for ecommerce expertise when President ... the online version of the highly respected Entrepreneur magazine. , ... ... selected Mr. Del Chiaro for the interview based on his proven ...
... on annual listOAKLAND, Calif., March 5 ... been recognized by DiversityMBA ... was ranked No. 1 in the publication,s fourth annual ... Diverse Managers to Work," which will hit newsstands in ...
... don,t offer emergency contraception pills to adolescents who ... because of misinformation about how the medicine works, ... of Philadelphia. Improved physician education may increase prescription ... said. Researchers surveyed 291 members of the ...
Cached Medicine News:Health News:Patients, Senate, House Members Identify Significant Medicare Savings While Increasing Quality of Patient Care 2Health News:Patients, Senate, House Members Identify Significant Medicare Savings While Increasing Quality of Patient Care 3Health News:Drug blocks 2 of world's deadliest emerging viruses 2Health News:Drug blocks 2 of world's deadliest emerging viruses 3Health News:GoTrybe.com Launched in Indiana to Promote Children's Health 2Health News:My1Stop.com President Michael Del Chiaro Interviewed by Entrepreneur.com for ecommerce Expertise 2Health News:Kaiser Permanente Recognized as Best Place for Diverse Managers 2Health News:Kaiser Permanente Recognized as Best Place for Diverse Managers 3Health News:Research Says Better Physician Education Would Improve Hospital Prescription of Emergency Birth Control to Teens 2Health News:Research Says Better Physician Education Would Improve Hospital Prescription of Emergency Birth Control to Teens 3
(Date:10/22/2014)... Oct. 21, 2014   BioNano Genomics , ... genomics research centers to purchase an Irys™ System ... National Cancer Institute (NCI), NIH Intramural Sequencing Center (NISC) ... Irys, obtaining a comprehensive view of a genome ... (NGS) does not deliver the scalability or reliability ...
(Date:10/22/2014)... 2014 InVivo Therapeutics Holdings Corp. (OTCQB: NVIV) ... revolutionizing spinal cord injury (SCI) treatment with their novel ... in tissue regrowth in the spinal cord area when ... FDA approved polymer, the scaffold ultimately breaks down to ... human body. NVIV has recently attracted significant investor attention ...
(Date:10/22/2014)... Calif. , Oct. 22, 2014  AcelRx ... announced that results from the  IAP310 study have ... Medicine (RAPM), a peer-reviewed journal with broad, ... 3 trial evaluating the safety and efficacy of ... tablet system (SSTS), for the treatment of post-operative ...
Breaking Medicine Technology:BioNano's Irys System Adopted by Leading Genomics Centers for Comprehensive Detection of Human Genome Structural Variation 2BioNano's Irys System Adopted by Leading Genomics Centers for Comprehensive Detection of Human Genome Structural Variation 3InVivo Therapeutics Analyst Coverage Initiated: Analyst Report by BrokerBank Securities, Inc. 2InVivo Therapeutics Analyst Coverage Initiated: Analyst Report by BrokerBank Securities, Inc. 3AcelRx Announces Publication of Zalviso Phase 3 Abdominal Trial Results 2
RCB™ Rotator Cuff Buttress is a completely resorbable plate that will alleviate suture migration in open or mini-Open rotator cuff repairs....
... The E-Z Tac™ implantThe USS Sports Medicine™ ... used to attach soft tissue to bone. The ... hole in the bone and is used to ... is made of a resorbable copolymer, a polyester ...
... Medicine™ AnchorSew™ 3 mm is a resorbable repair ... Medicine ArthroSew suturing device to attach soft tissue ... implanted into a prepared hole in the bone, ... soft tissue anchors are made of a resorbable ...
Sutureless Harpoon Tip...
Medicine Products: