Navigation Links
Moffitt Cancer Center researchers identify genetic variants predicting aggressive prostate cancers
Date:6/19/2013

Researchers at Moffitt Cancer Center and colleagues at Louisiana State University have developed a method for identifying aggressive prostate cancers that require immediate therapy. It relies on understanding the genetic interaction between single nucleotide polymorphisms (SNPs). The goal is to better predict a prostate cancer's aggressiveness to avoid unnecessary radical treatment.

Their study was published in the online journal PLOS ONE in April.

According to the authors, prostate cancer accounts for 20 percent of all cancers and 9 percent of cancer deaths. It is the most common cancer and was the second leading cause of cancer death in American men in 2012.

"For most prostate cancer patients, the disease progresses relatively slowly," said study co-author Hui-Yi Lin, Ph.D., assistant member of the Chemical Biology and Molecular Medicine Program at Moffitt. "However, some cases grow aggressively and metastasize. It is often difficult to tell the difference between the two."

The two treatment options for aggressive prostate cancer radical surgery and radiation therapy have negative side effects, such as incontinence and erectile dysfunction. It is why the authors believe there is an urgent need for biomarkers that can identify or predict aggressive types of prostate cancer.

Through examining combinations of genetic variants, or SNP-SNP interactions, the researchers have identified and validated several genetic changes that are related to prostate cancer aggressiveness. Their work also shows that the epithelial growth factor receptor may be the hub for these interactions because it is involved in the growth of blood vessels (angiogenesis), which in turn stimulates tumor growth.

"Our findings identified five SNP-SNP interactions in the angiogenesis genes associated with prostate cancer aggressiveness," explained study co-author Jong Y. Park, Ph.D., associate member of Moffitt's Cancer Epidemiolog
'/>"/>

Contact: Kim Polacek
kim.polacek@moffitt.org
813-745-7408
H. Lee Moffitt Cancer Center & Research Institute
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Certain types of graft-versus-host disease may increase risk of death, Moffitt researcher says
2. Quality-of-life issues need to be addressed for CML patients, Moffitt researchers say
3. Moffitt Cancer Center researchers analyze how Spanish smoking relapse booklets are distributed
4. Cancer biorepository speeds clinical trials, drug development, Moffitt analysis shows
5. Deficiency in p53 anti-tumor protein delays DNA repair after radiation, Moffitt researchers say
6. Some minorities believe they are less likely to get cancer compared to whites, Moffitt study shows
7. 2-drug combo more effective in treating sarcomas, Moffitt Cancer Center study shows
8. Moffitt Cancer Center researchers discuss new frontiers in breast cancer screening
9. Moffitt Cancer Center researchers say 1 specific microrna promotes tumor growth and cancer spread
10. Moffitt Researchers help lead international efforts that find new genetic links to ovarian cancer
11. Moffitt researchers analyze HPV vaccination disparities among girls from low-income families
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/29/2015)... Intermountain Healthcare of Salt ... Stratus Video Interpreting for on-demand medical ... and timely care for patients with limited ... video remote interpreting (VRI) services will supplement ... quickly access qualified medical interpretation in nearly ...
(Date:5/29/2015)... York, NY (PRWEB) May 29, 2015 ... USA Today, with a circulation of approximately 250,000 and ... distributed nationally, through a vast social media strategy, and ... outlets. To explore the digital version of the campaign, ... cover of the print publication. Inside, the actress, model ...
(Date:5/29/2015)... Mediaplanet has joined forces with Colorescience ... Skin Health is a cross-platform campaign with a national ... New York, Los Angeles, and Chicago, the campaign is ... counterpart will reach a national audience through one of ... Skin Health campaign and Colorescience, click here . ...
(Date:5/29/2015)... May 29, 2015 OncLive proudly announces ... dozen medical pioneers recognized by a panel of eminent ... of cancer treatment. Honorees will be introduced and celebrated ... Award Ceremony, held 8:30-11:00 p.m. CDT at The Chicago ... honorees are being recognized for groundbreaking accomplishments, in fields ...
(Date:5/29/2015)... May 29, 2015 Healthpointe is ... with specialists, physical therapy, and injections , For ... back and/or lower back pain, Healthpointe has a ... for herniated discs, disc protrusions and other causes ... , Healthpointe’s team of renowned surgeons are now ...
Breaking Medicine News(10 mins):Health News:Stratus Video Interpreting Partners With Intermountain Healthcare to Provide On-Demand Interpretation Services for Patients With Limited English Proficiency (LEP) 2Health News:Stratus Video Interpreting Partners With Intermountain Healthcare to Provide On-Demand Interpretation Services for Patients With Limited English Proficiency (LEP) 3Health News:Stratus Video Interpreting Partners With Intermountain Healthcare to Provide On-Demand Interpretation Services for Patients With Limited English Proficiency (LEP) 4Health News:Mediaplanet Launches “Skin Health” Campaign Featuring Colorescience 2Health News:OncLive's 2015 Giants of Cancer Care™ Awards Announced Today 2Health News:OncLive's 2015 Giants of Cancer Care™ Awards Announced Today 3Health News:OncLive's 2015 Giants of Cancer Care™ Awards Announced Today 4Health News:Healthpointe’s Pain Management Specialists Now Providing Lumbar Epidural Injections in Los Angeles County 2Health News:Healthpointe’s Pain Management Specialists Now Providing Lumbar Epidural Injections in Los Angeles County 3
... Researchers from Harvard School of Public Health (HSPH), Massachusetts ... Research (NBER), and Providence Health & Services have found ... increases health care use, reduces financial strain on covered ... is the first study to evaluate the impact of ...
... today [Thursday 7 July] at the Annual Scientific Meeting of ... the Academic Unit of Primary Health Care, University of Bristol. ... 2008, uses HPV vaccine that is effective against the two ... offers 70 per cent protection against cervical cancer. However, ...
... 6, 2011) One consequence of the expanded access to ... shortfall in the necessary numbers of physicians and other advanced ... issue of the Journal of the American College of ... the combined workforce of physicians, advance practice nurses, and physician ...
... HealthDay Reporter , WEDNESDAY, July 6 (HealthDay ... multiple sclerosis have been dimmed by recent research in ... found no support for prior studies connecting breast-feeding with ... disorder commonly known as MS. Instead, they ...
... , WEDNESDAY, July 6 (HealthDay News) -- Airline pilots ... debilitating fatigue that could hamper their flying performance, a ... U.S. Federal Aviation Administration should find ways to reduce ... to the report from the U.S. National Research Council. ...
... HealthDay Reporter , WEDNESDAY, July 6 (HealthDay News) -- ... rise in various parts of the country, and this one ... by a microscopic parasite that attacks blood cells, causing flu-like ... Lyme disease, which is caused by bacteria, babesia microti parasites ...
Cached Medicine News:Health News:Medicaid increases use of health care, decreases financial strain, improves health 2Health News:Medicaid increases use of health care, decreases financial strain, improves health 3Health News:Lack of clarity about HPV vaccine and the need for cervical cancer screening 2Health News:Future labor shortfalls of medical professionals predicted due to new demands of health-care reform 2Health News: Breast-Feeding May Not Protect Moms Against MS Relapse 2Health News: Breast-Feeding May Not Protect Moms Against MS Relapse 3Health News:Long Commutes for Pilots May Hamper Flying Performance: Study 2Health News:Long Commutes for Pilots May Hamper Flying Performance: Study 3Health News:Long Commutes for Pilots May Hamper Flying Performance: Study 4Health News:A Deadly New Reason to Avoid Deer Ticks 2Health News:A Deadly New Reason to Avoid Deer Ticks 3
(Date:5/29/2015)... 2015 Educating the community continues to ... the Advancement of Wound Care (AAWC), which was ... AAWC,s corporate partners, the Association provides medical professionals ... AAWC website at http://aawconline.org/education-for-the-generalist/ . The portal ... links to various CME/CEU educational programs. This education ...
(Date:5/28/2015)... HOUSTON , May 28, 2015 /PRNewswire/ - ESSA Pharma ... results for the second quarter and three and six months ... in Canadian dollars and in accordance with International Financial Reporting ... ESSA recorded a net loss of $5.9 million ($0.35 per ... (Q2-2015), compared to a net loss of $0.4 million ($0.03 ...
(Date:5/28/2015)... 2015  Maetrics ( http://maetrics.com ), a leading international ... up a successful conference, "The cost of non-compliance -- How ... in Zurich . ... Switzerland -based team, experts provided insights ... field to an exclusive local audience. The event was ...
Breaking Medicine Technology:The Association for the Advancement of Wound Care Educates the Public 2Essa Pharma Inc. Reports Second Quarter 2015 Financial Results 2Essa Pharma Inc. Reports Second Quarter 2015 Financial Results 3Essa Pharma Inc. Reports Second Quarter 2015 Financial Results 4Essa Pharma Inc. Reports Second Quarter 2015 Financial Results 5Maetrics Hosts Innovative Medical Cluster Event in Switzerland 2
... 5 GlaxoSmithKline [NYSE: GSK] today announced that ... Oncologic Drugs Advisory Committee (ODAC) voted unanimously in ... the panel voted that the benefit-to-risk profile is ... (RCC). Pazopanib is an investigational, oral treatment for ...
... Oct. 5 In a settlement that is essentially ... (NLRB), which conducted a two-month investigation into massive illegal ... company, the giant HCA chain, have pledged to end ... of registered nurses. , The settlement stems from a ...
Cached Medicine Technology:GlaxoSmithKline Receives Unanimous FDA Panel Approval Recommendation for VOTRIENT(TM) 2GlaxoSmithKline Receives Unanimous FDA Panel Approval Recommendation for VOTRIENT(TM) 3Faced With Federal Prosecution, MountainView Agrees to Stop Harassment of RNs in Settlement With Labor Board 2
... mg/kg sulfate (SO 4 ) ≤ 1000 mg/kg Cation ... Co ≤ 5 mg/kg Cr ≤ 10 mg/kg Cu ... 5 mg/kg Mg ≤ 5 mg/kg Mn ≤ 5 ... Pb ≤ 5 mg/kg Zn ≤ 5 mg/kg Special ...
Inquire...
... A low temperature agarose for special ... Optimal for in-gel restriction digestion/ligation and DNA ... manageable clear gel that provides excellent resolution ... 65°C and remains fluid at 37°C for ...
... Agarose 3:1 HRB™ (High Resolution Blend), ... to provide high resolution of small nucleic ... analysis of DNA fragmanets less than 1,000 ... patterns without smearing of high background fluorescence. ...
Medicine Products: