Navigation Links
Moffitt Cancer Center researchers identify drivers of sarcoma growth and survival
Date:5/1/2012

To better understand the signaling pathways active in sarcomas, researchers at Moffitt Cancer Center used state-of-the-art mass spectrometry-based proteomics to characterize a family of protein enzymes that act as "on" or "off" switches important in the biology of cancer. The tyrosine kinases they identified, the researchers said, could act as "drivers" for the growth and survival of sarcomas.

Sarcomas are relatively rare forms of cancer. In contrast to carcinomas, which arise from epithelial cells (in breast, colon and lung cancers, for example), sarcomas are tumors derived from bone, fat, muscle or vascular tissues.

"Sarcomas are rare, diverse malignancies that arise from connective tissues," said study lead author Eric B. Haura, M.D., program leader for Experimental Therapeutics. "We hypothesized that we could identify important proteins that drive the growth and survival of these poorly understood sarcomas using an approach to characterize signaling proteins using mass spectrometry."

According to Haura, whose lab focuses on signaling pathways in cancer and understanding the role of kinases, protein phosphorylation plays a significant role in a wide range of cellular processes and is commonly disrupted in diseases such as cancer. The study approach is novel by engaging proteomics, an emerging and increasingly powerful approach to study proteins in disease in a more global and unbiased manner.

In this study, the Moffitt researchers identified 1,936 unique tyrosine phosphorylated peptides corresponding to 844 unique phospho-tyrosine proteins and found 39 tyrosine kinases in sarcoma cells. Of the 99 tyrosine kinases present in the human genome, the research team identified peptides corresponding to nearly 40 percent of the tyrosine kinome.

"Tyrosine kinases play an important role in controlling the hallmarks of cancer, and they have a proven track record as druggable targets for cancer treatment. Our goal was to pro
'/>"/>

Contact: Patty Kim
patty.kim@moffitt.org
813-745-7322
H. Lee Moffitt Cancer Center & Research Institute
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Researchers creating designer lymph nodes based on Moffitts Total Cancer Care initiative
2. Moffitt researcher awarded GE grant to develop tool to detect breast cancer metastasis genetic risks
3. Moffitt researcher publishes book on nutritional management of cancer treatment effects
4. Moffitt researchers find adolescents with cancer concerned about their future reproductive health
5. Moffitt Cancer Center researchers working at frontiers of melanoma research
6. Moffitt Cancer Center researchers: Quality of life as important as quantity of life
7. Moffitt researchers find cancer therapies affect cognitive functioning among breast cancer survivors
8. New Moffitt Cancer Center patent promises to accelerate cancer trials
9. Moffitt, Sanford-Burnham and Florida Hospital create Personalized Medicine Partnership of Florida
10. Fibroblasts contribute to melanoma tumor growth, say Moffitt Cancer Center researchers
11. Moffitt Cancer Center researchers find potential target for treating metastatic cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/20/2014)... Punzoné , the first line of ... a lot to celebrate this month. October marks Italian Heritage ... and contributions of Americans of Italian heritage and Italians in ... it shares its favorite Italian cocktails and encourages everyone to ... even if it is only in a glass. , ...
(Date:10/20/2014)... Maryland, USA (PRWEB) October 20, 2014 ... to track interventions? Here comes a wonderful app Metassessor ... mobile app development company helped its client “Intervention ... more efficiently. The app is designed for iOS 4.3 ... iPod touch. This app is optimized for iPhone 5. ...
(Date:10/19/2014)... 20, 2014 The leading review ... http://www.top10bestseohosting.com/go/iPage/ ) and GreenGeeks are the best Dedicated ... for those who want to buy high quality ... , The IT manager of Top10BestSEOHosting.com says, “We ... recommended suppliers for everyone. A lot of the ...
(Date:10/19/2014)... 2014 Dr. Babatunde Osotimehin, Executive Director ... of a ceasefire agreement that is expected to lead ... who were kidnapped from the north-eastern Nigerian town of ... long enough, and it is high time they are ... Osotimehin. , "We owe it to these girls to ...
(Date:10/19/2014)... 20, 2014 Having been working in the ... knowledge of customer needs. According to James, one of the ... dazzling sequins, or with high-low skirts that add beauty to ... demand. Recently, LunaDress has unveiled its new selection of 2014 ... the company’s brand new items are available in over 20 ...
Breaking Medicine News(10 mins):Health News:Celebrate Italian Heritage Month With Authentic Cocktails from Punzoné: The Only Ultra Premium Line of Organic Imported Italian Vodka 2Health News:Celebrate Italian Heritage Month With Authentic Cocktails from Punzoné: The Only Ultra Premium Line of Organic Imported Italian Vodka 3Health News:Celebrate Italian Heritage Month With Authentic Cocktails from Punzoné: The Only Ultra Premium Line of Organic Imported Italian Vodka 4Health News:Metassessor App Launched: an RTI tool for Teachers & Parents 2Health News:Metassessor App Launched: an RTI tool for Teachers & Parents 3Health News:Top10BestSEOHosting.com Considers iPage And GreenGeeks As The Best Dedicated Server Hosting Suppliers 2Health News:2014 Long Prom Dresses From LunaDress Now Available In Over 20 Popular Designs 2
... role as a,leading supporter and advocate of ... Provider Organizations (AAPPO) today,announced a strategic alliance ... significantly enhance benefits for members of both,associations., ... to fuel,further change in the delivery of ...
... January 3, 2008 Shire plc (LSE: SHP, NASDAQ: ... announced that it has received approval from the U.S. ... strengths for the attention deficit hyperactivity disorder (ADHD) treatment, ... strengths of 20 mg, 40 mg and 60 mg ...
... Five Great-Tasting Potato, Chip Flavors Featuring Cholesterol-Lowering Plant ... ... Chips, LOS ANGELES, Jan. 3 Corazonas Foods ... potato chip into a heart-healthy culinary delight with the ...
... Pa., Jan. 3 Consumers who,purchased or were ... Schumacher,s Inn in Austin, Potter County, should not ... contamination, Health Secretary Dr. Calvin B.,Johnson said today., ... restaurant should,immediately contact the Pennsylvania Department of Health, ...
... of weight loss resolutions made,on January 1st quickly fall ... so,hard. Author, reporter and weight-management expert Dr. Christine Dumas,says ... every day., Listen to this report from ... video, audio, text, graphics and,photos for free and unrestricted ...
... as much carbon monoxide as a pack of smokes , , ... puffs from a hookah -- a kind of tobacco water ... carbon monoxide punch as a pack-a-day cigarette habit, a new ... toxic gas, making it impossible to directly compare hookah use ...
Cached Medicine News:Health News:AAPPO and HCAA Form Partnership to Enhance Services to Meet the Changing Business Needs of PPOs and TPAs 2Health News:FDA approves additional dosage strengths of Vyvanse 2Health News:Corazonas Launches First and Only Cholesterol-Reducing Potato Chips 2Health News:Health Department Warns Consumers of Home-Canned Soup Linked to Potter County Restaurant 2Health News:Hookah Smoking as Tough on Lungs as Cigarettes 2Health News:Hookah Smoking as Tough on Lungs as Cigarettes 3
(Date:10/20/2014)... de octubre de 2014  PneumRx, Inc. ( ... la pulmonología intervencional, anunció hoy la conclusión de ... meses antes de lo programado. El Estudio Clínico RENEW ... de investigación (IDE) aprobada por la FDA (Administración ... espiral de reducción de volumen pulmonar PneumRx RePneu, ...
(Date:10/20/2014)... Oct. 20, 2014 Valeritas, Inc., a leader ... patients with Type 2 diabetes, announced today that it ... Award. The award was presented October 16 th ... Columbus, Ohio . The Cardinal ... a variety of metrics specifically targeted at the importance ...
(Date:10/20/2014)... 2014 Lpath, Inc. (NASDAQ: ... therapeutics, received official notification from the European Patent Office ... patent supporting its iSONEP™ and ASONEP™ programs. ... No. 2087002, claims compositions of matter related to ... compounds, iSONEP and ASONEP. Sonepcizumab is an antibody ...
Breaking Medicine Technology:PneumRx concluye inscripción en prueba fundamental RENEW 2PneumRx concluye inscripción en prueba fundamental RENEW 3Valeritas Receives 2014 Cardinal Health Supply Chain Excellence Award 2Valeritas Receives 2014 Cardinal Health Supply Chain Excellence Award 3Lpath Granted Key European Patent Related to iSONEP and ASONEP Programs 2Lpath Granted Key European Patent Related to iSONEP and ASONEP Programs 3Lpath Granted Key European Patent Related to iSONEP and ASONEP Programs 4
... Mich., Jan. 9, 2012  Diplomat Specialty Pharmacy, the nation,s ... today it has received limited distribution rights from ... On November 18, 2011, EYLEA ... Drug Administration and is indicated for the treatment ...
... Calif., Jan. 9, 2012 Uptake Medical ® ... C funding round. The round was led by Singapore-based ... Ventures, GBS Venture Partners, WRF Capital, Arboretum Ventures and ... managing partner, will join the Uptake Medical board of ...
Cached Medicine Technology:Diplomat Specialty Pharmacy to Provide Specialty Pharmacy Services for EYLEA™ (aflibercept) Injection 2Uptake Medical Announces Successful Completion of Series C Financing 2
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: