Navigation Links
Moffitt Cancer Center researchers find regulatory T-cell clue to help prevent GVHD
Date:10/31/2011

TAMPA, Fla. (Oct. 31, 2011) Graft-versus-host disease (GVHD) is a serious risk in many kinds of cell transplants, including for stem cell transplants carried out when stem cells are partially depleted of conventional T cells, which play an important role in the immune system. Now, researchers at Moffitt Cancer Center have tested a process by which T regulatory cells (Tregs) can be "expanded" to help prevent GVHD.

"Tregs play a dominant role in transplantation tolerance," said Claudio Anasetti, M.D., corresponding author of a study carried out by a team of Moffitt investigators and published in a recent issue of the journal Blood. "Adoptive transfer of freshly isolated human Tregs has prevented GVHD in patients treated with allogeneic (other than self-donated) stem cell transplants. However, some transplants will require a greater number of Tregs that can only be obtained through expanding Tregs outside of the body."

The researchers suggest that therapeutic applications will require Tregs to be expanded by more than a hundredfold.

"There is a need to improve on Treg expansion protocols before allo-specific Tregs can be brought into the clinic," said Anasetti, chair of the Department of Blood & Marrow Transplant at Moffitt.

The authors note that a recently adopted expansion process has used dendritic cells to activate Tregs.

"Dendritic cells have been identified as having unique capabilities for expanding Tregs," cited Anasetti, whose work focuses on preventing GVHD in mouse models and in humans.

To carry out the present study, Anasetti and his fellow researchers adopted a one-step process to expand allo-specific Tregs by dendritic cell stimulation.

"Our work opens an opportunity to study tissues as sources of antigens for indirect presentation to activate and expand therapeutic Tregs," concluded Anasetti. "If effective, this approach could prevent GVHD while sparing, at least in part, graft-versus-leukemia or graft-versus-tumor responses."


'/>"/>

Contact: Ferdie De Vega
Ferdinand.DeVega@moffitt.org
813-745-7858
H. Lee Moffitt Cancer Center & Research Institute
Source:Eurekalert

Related medicine news :

1. Moffitt Cancer Center researchers find more clues to causes of breast cancer
2. Moffitt researchers find possible key to preventing chemotherapy resistance in ovarian cancer
3. Moffitt Cancer Center researchers use new tool to counter multiple myeloma drug resistance
4. Moffitt Cancer Center and GLG Pharma LLC sign licensing agreement to develop the next generation of targeted anti-cancer therapeutics
5. Moffitt Cancer Center and GLG Pharma, LLC sign licensing agreement to develop the next generation of targeted anti-cancer therapeutics
6. Computer-based tool to improve diagnosis and prognosis for cancer patients
7. Research highlights training to improve colorectal cancer detection
8. Mayo Clinic: Short training course significantly improves detection of precancerous polyps
9. First-of-its-kind study creates new tool for targeted cancer drug development
10. Controlling gene expression to halt cancer growth
11. Fighting a smarter war against cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/12/2016)... ... February 12, 2016 , ... ... Series at Zuckerberg San Francisco General Hospital on April 5-7. The series is ... and create new habits. The workshops cover a broad range of topics, including ...
(Date:2/12/2016)... , ... February 12, 2016 , ... ... Service (WaaS), today announced the integration of Clarity Intelligence Platform (CIP) into Cielo®, ... to offer real-time business intelligence (BI) to their small and medium business (SMB) ...
(Date:2/12/2016)... ... February 12, 2016 , ... Every winter, someone is killed, injured or loses ... Penn Burn Center, part of the Allegheny Health Network, has partnered with Etna ... “Space Heaters Need Space” campaign. , “Space Heaters Need Space” aims to ...
(Date:2/12/2016)... ... February 12, 2016 , ... Fisher House Foundation Chairman ... John J. Lee, Nevada Military Support Alliance president Scott Bensing, and Peggy Kearns Director, ... VA Southern Nevada Healthcare System. This will be the first Fisher House in ...
(Date:2/12/2016)... ... February 12, 2016 , ... AssureVest Insurance Group, a locally owned insurance ... drive that will raise funds earmarked to purchase computers and software for Mrs. Harrison’s ... “My school is in a low-income area and has more than 60 2nd and ...
Breaking Medicine News(10 mins):
(Date:2/12/2016)... 12, 2016 ... http://www.sedar.com ) und der ... abrufbar.    --> http://www.sedar.com ) ... http://www.telestatherapeutics.com abrufbar.    --> ... seinen Konzernabschluss des zweiten Quartals und ...
(Date:2/12/2016)... FRAMINGHAM, Mass. , Feb. 12, 2016   ... scheduled a conference call and webcast to discuss its ... December 31, 2015, on Thursday, February 25, 2016 at ... financial results prior to the conference call and webcast.  ... the company,s financial results, highlights from the fourth quarter ...
(Date:2/12/2016)... Inc., a medical device company that pioneered the use of the ... device indicated for fusion for certain disorders of the sacroiliac (SI) ... Contractor (MAC) covering the states of Connecticut , ... Massachusetts , Minnesota , ... Rhode Island , Vermont and ...
Breaking Medicine Technology: