Navigation Links
Moffitt Cancer Center researchers find potential target for treating metastatic cancer
Date:12/13/2011

TAMPA, Fla. (Dec. 13, 2011) Finding ways to counteract or disrupt the invasive nature of cancer cells, called "metastasis," has been a long-term goal of cancer researchers. Now, researchers at Moffitt Cancer Center in Tampa, Fla., have identified an interactive pathway that regulates metastases in some cancers that may be vulnerable to chemical targeting in order to prevent cancer cell proliferation and tumor growth.

Ongoing collaboration by researchers in Moffitt's Departments of Tumor Biology and Drug Discovery has revealed the potential for combating metastatic disease by disrupting the interaction between the retinoblastoma tumor suppressor protein (Rb) and Raf-1 (a gene with a potential to cause cancer) with RRD-251, a selective, chemical disrupter of Rb-Raf-1 interaction.

Their recent study, aimed at understanding the association between Rb-Raf-1 and genes known to be over-expressed in metastatic non-small lung cancer, was published in the recent issue of Cancer Research, a journal of the American Association for Cancer Research. This work, using a mouse model, was a continuation of the researchers' study of RRD-251's successful disruption of Rb-Raf-1 interaction in metastatic melanoma in test mice, a study published in Molecular Cancer Therapeutics in 2010.

"The Rb gene is mutated in a variety of cancers," said study corresponding author Srikumar P. Chellappan, Ph.D., chair of Moffitt's Department of Tumor Biology and scientific director of the National Functional Genomics Center. "Our earlier studies have shown that Raf-1 interacts with Rb early in the cell cycle and facilitates its inactivation."

The ongoing work of Chellappan and his colleagues in Moffitt's Department of Tumor Biology focuses on understanding the mechanisms by which external signals regulate cell proliferation and how a loss of regulation may cause cancer. They work extensively with the Rb protein, the Raf-1 signaling molecule, and E2Fs, g
'/>"/>

Contact: Ferdie De Vega
Ferdinand.DeVega@moffitt.org
813-745-7858
H. Lee Moffitt Cancer Center & Research Institute
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Moffitt researchers will be strong participants in American Society of Hematology meeting
2. Moffitt Cancer Center researchers find MK1775 active against sarcomas
3. Moffitt Cancer Center researchers find men less willing to be screened for cancer
4. Moffitt Cancer Center researchers unravel biochemical factor important in tumor metastasis
5. Moffitt Cancer Center researchers find regulatory T-cell clue to help prevent GVHD
6. Moffitt Cancer Center researchers find more clues to causes of breast cancer
7. Moffitt researchers find possible key to preventing chemotherapy resistance in ovarian cancer
8. Moffitt Cancer Center researchers use new tool to counter multiple myeloma drug resistance
9. Moffitt Cancer Center and GLG Pharma LLC sign licensing agreement to develop the next generation of targeted anti-cancer therapeutics
10. Moffitt Cancer Center and GLG Pharma, LLC sign licensing agreement to develop the next generation of targeted anti-cancer therapeutics
11. Birth Defects Seem Rare in Kids of Childhood Cancer Survivors
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/30/2014)... research group at the DFG Research Center for Regenerative ... Dresden (CRTD) demonstrated for the first time the in ... three dimensions from mouse embryonic stem cells. Correct spatial ... the dorsal/ventral axis was observed., This study has been ... Cell Reports " on 30.10.2014 ., For many years ...
(Date:10/30/2014)... NC (PRWEB) October 30, 2014 Don ... commercial, and health insurance plans for North Carolina residents, ... satellite office in Burlington’s Holly Hill Mall. The new ... with agents already helping customers through all facets of ... purchase. , Allred Insurance spokesman Scott Allred couldn’t be ...
(Date:10/30/2014)... Radio listeners who indicate use of ... impact of traditional radio commercials and have overwhelmingly endorsed ... influence a purchasing decision. , Those are some highlights ... by radio marketing company CRN International. The research is ... of respondents who indicated they have purchased or considered ...
(Date:10/30/2014)... Chicago, IL (PRWEB) October 30, 2014 Dr. ... launched a new website for his practices; OB GYN ... Chicago, IL . This website contains important information about ... covers as well as downloadable patient forms in English and ... use and the service pages on the website provide Dr. ...
(Date:10/30/2014)... Rock Hill, South Carolina (PRWEB) October 30, 2014 ... a muscle, and should be more vigorously exercised to ... Grewal. He recently authored the book ‘Dementia Express: Lose ... , The book uses counterintuitive reasoning and sometimes conflicting ... an obstacle course for the mind, a reader must ...
Breaking Medicine News(10 mins):Health News:Reconstruction of a patterned piece of spinal cord in 3-D culture 2Health News:Allred Insurance Satellite Office Grand Opening 2Health News:CRN Research On Radio Messaging Effectiveness Now Available In Four Specific Product Categories 2Health News:CRN Research On Radio Messaging Effectiveness Now Available In Four Specific Product Categories 3Health News:Dr. Joseph Furlin Launches New Website with Information about Care Services 2Health News:‘Dementia Express’ Offers Contradictory and Sometimes Reverse Thinking, All to Keep its Reader on Their Toes With an Active Mind. 2
... research scientists, students, and educators from around the world ... Association for Dental Research (IADR) holds its 87th General ... This is also the 38th Annual Meeting of the ... Annual Meeting of the Canadian Association for Dental Research ...
... relationship between coping strategies and quality of life (QOL) ... today in the online edition of Journal of ... quality of life among younger women with breast cancer ... , "It is generally assumed that coping strategies impact ...
... at American Burn Association MeetingST. PETERSBURG, Fla., March 24 ... (LSE: SN; NYSE: SNN ) will host ... at the 41st Annual Meeting of the American Burn ... present their clinical work with Smith & Nephew,s VERSAJET ...
... Hyland Software chief technology officer during a free webinar ... combats RAC challenges with document management CLEVELAND, March 24 ... three letters - RAC. The RAC, or Recovery Audit Contractor ... Medicare. And it was effective in doing just that - ...
... Cancer Center performed the world,s first successful minimally invasive ... laparoscope holder. The technology, developed in France and tested ... in a cancer setting in the United States this ... is among only a handful of institutions worldwide using ...
... "The United States is experiencing a primary care ... Jeffrey P. Harris, MD, FACP, president of the American ... Representatives Energy & Commerce Health Subcommittee. "The demand for ... the nation,s supply of primary care dwindles." , ...
Cached Medicine News:Health News:IADR holds 87th General Session and Exhibition 2Health News:Quality of life may impact coping strategies of young women with breast cancer 2Health News:Quality of life may impact coping strategies of young women with breast cancer 3Health News:Smith & Nephew Announces Symposium for Optimizing Outcomes in Burn Care 2Health News:Smith & Nephew Announces Symposium for Optimizing Outcomes in Burn Care 3Health News:Smith & Nephew Announces Symposium for Optimizing Outcomes in Burn Care 4Health News:Not Ready for RAC? Award-Winning Document Management Suite Can Help Protect Your Bottom Line 2Health News:Not Ready for RAC? Award-Winning Document Management Suite Can Help Protect Your Bottom Line 3Health News:Not Ready for RAC? Award-Winning Document Management Suite Can Help Protect Your Bottom Line 4Health News:Fox Chase performs the world’s first successful ViKY robot-assisted surgery for pancreatic tumors 2Health News:Fox Chase performs the world’s first successful ViKY robot-assisted surgery for pancreatic tumors 3Health News:US experiencing primary care shortage 'likes of which we have not seen' 2Health News:US experiencing primary care shortage 'likes of which we have not seen' 3
(Date:10/30/2014)... -- Hospital stretchers are apparatus used to transport ... or outside of medical infrastructure premises. In addition ... for several specialized functions such as hospital beds, ... The hospital stretchers market report studies the ... of hospital stretchers globally. The hospital stretchers market ...
(Date:10/27/2014)... Calif. , Oct. 27, 2014  RenovoRx, a ... blood flow and delivery of fluids to selected sites ... Board of Directors has appointed Shaun Bagai ... of the RenovoRx Board of Directors. Bagai brings more ... industry. Bagai joined RenovoRx in June 2014 ...
(Date:10/27/2014)... 27, 2014  Demonstrations by more than 50 ... featured this week in Chicago ... more than 7,000 emergency physicians are discussing the ... educational courses. These best-of-the-best innovations are ... emergency department environments, including three equipped trauma bays. ...
Breaking Medicine Technology:Hospital Stretchers Market - Global Industry Analysis, Size, Share, Growth, Trends and Forecast, 2013 - 2019 2Hospital Stretchers Market - Global Industry Analysis, Size, Share, Growth, Trends and Forecast, 2013 - 2019 3RenovoRx Board Names Shaun R. Bagai as CEO 2Emergency Medicine of the Future Demonstrated at ACEP14 2Emergency Medicine of the Future Demonstrated at ACEP14 3Emergency Medicine of the Future Demonstrated at ACEP14 4Emergency Medicine of the Future Demonstrated at ACEP14 5Emergency Medicine of the Future Demonstrated at ACEP14 6Emergency Medicine of the Future Demonstrated at ACEP14 7Emergency Medicine of the Future Demonstrated at ACEP14 8Emergency Medicine of the Future Demonstrated at ACEP14 9Emergency Medicine of the Future Demonstrated at ACEP14 10Emergency Medicine of the Future Demonstrated at ACEP14 11Emergency Medicine of the Future Demonstrated at ACEP14 12Emergency Medicine of the Future Demonstrated at ACEP14 13Emergency Medicine of the Future Demonstrated at ACEP14 14Emergency Medicine of the Future Demonstrated at ACEP14 15
... Oct. 5 Osseon Therapeutics, Inc. announced its ... North American Spine Society,s (NASS) annual meeting in ... facilitate treatment of vertebral compression fractures (VCFs) that ... fibrotic metastases.  The Osseoflex DR Steerable Bone Drill ...
... SUNNYVALE, Calif., Oct. 5 Accuray Incorporated (Nasdaq: ... of radiosurgery, announced today that the company was awarded a ... U.S. Government to be used toward further development of a ... grant will fund the development of a next generation, compact ...
Cached Medicine Technology:Osseon® Therapeutics Introduces New Osseoflex® DR Steerable Bone Drill 2Accuray Awarded $1 Million Grant by U.S. Government 2Accuray Awarded $1 Million Grant by U.S. Government 3
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: