Navigation Links
Moffitt Cancer Center researchers find acidic pH microenvironments in tumors aid tumor cell survival
Date:9/5/2012

atmospheric oxygen levels and they found that the cell's stress response could lead to chronic autophagy even when nutrients and oxygen were in adequate supply.

"We found that cells subjected to transient and chronic low pH growth conditions demonstrate elevated markers for autophagy and are dependent on this process for prolonged survival in acidic environments," explained Jonathan W. Wojtkowiak, lead author of the study and postdoctoral fellow at Moffitt. "A hallmark of cancer is the ability of cancer cells to evade apoptosis. Autophagy supports this by playing a tumor promoter and survival role under certain circumstances during different stages of tumorogenesis."

Their study demonstrated the importance of autophagy in low pH-adapted breast and pancreatic cancer cell lines and the dependence of these cells on autophagy for survival to acidic tumor microenvironment. According to the researchers, they identified a potential therapeutic strategy of using an autophagy inhibitor, one that does not affect cells under neutral conditions.


'/>"/>

Contact: Kim Polacek
kim.polacek@moffitt.org
813-745-7408
H. Lee Moffitt Cancer Center & Research Institute
Source:Eurekalert

0

GOOD

Page: 1 2

Related medicine news :

1. Review finds some evidence for chemo brain in breast cancer survivors, Moffitt Cancer Center says
2. Moffitt Cancer Center researchers and colleagues identify PHF20, a regulator of gene P53
3. Moffitt Cancer Center melanoma expert reviews unique adverse events with newly approved drug
4. Moffitt Cancer Center researchers validate molecular signature to predict radiation therapy benefit
5. Moffitt Cancer Center researchers discover how cancer cells hijack a mechanism to grow
6. Attitudes toward outdoor smoking ban at moffitt Cancer Center evaluated
7. Moffitt Cancer Center researcher & colleagues test new drug for patients with neuroendocrine tumors
8. Moffitt Cancer Center researchers find potential key to new treatment for mantle cell lymphoma
9. Moffitt Cancer Center study validates activity of rare genetic variant in glioma
10. Moffitt researchers find cutaneous human papillomavirus infection a risk factor for skin cancer
11. Moffitt Cancer Center researchers test drug combinations to prevent graft vs. host disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/21/2013)... New York, New York (PRWEB) May 21, 2013 ... for Wright Conserve hip replacement lawsuits ... issued an Order in response to a request from ... employees of the Defendant. The May 17th Order ... such interviews may be conducted. (In re: Wright Medical ...
(Date:5/21/2013)... Hillsboro, OR (PRWEB) May 21, 2013 ... curing systems at the 20th Annual IMI European ... As a proven market leader, Phoseon continues to invest ... while accelerating the adoption of UV LED curing in ... of product families on the market offering both air ...
(Date:5/21/2013)... Los Angeles, CA (PRWEB) May 21, 2013 ... combat sports organization, and Bodybuilding.com, the largest online retailer ... bring you a new reality-based sports show, Warrior Island. ... fans vote on; YouTube, Facebook & Twitter, with our ... Warrior Island maroons these elite fighters on an ...
(Date:5/21/2013)... May 21, 2013 Modern couples ... help of Texas Counseling’s Sexuality and Relationship Workshops, ... the development of healthier habits for their relationship. ... for both couples and individuals at Texas Counseling. ... relationships and learn skills to develop long term ...
(Date:5/21/2013)... the roles two proteins, thrombospondin-1 and prosaposin, play ... has identified a five-amino acid fragment of prosaposin ... of prostate, breast and lung cancer. The findings ... metastasis in a variety of cancers. , ... at Boston Children,s Hospital, Vivek Mittal, PhD, at ...
Breaking Medicine News(10 mins):Health News:Wright Hip Lawsuit News: Bernstein Liebhard LLP Notes Issuance of New Order in Federal Wright Conserve Hip Replacement Litigation 2Health News:Wright Hip Lawsuit News: Bernstein Liebhard LLP Notes Issuance of New Order in Federal Wright Conserve Hip Replacement Litigation 3Health News:Bodybuilding.com Partners with Global Proving Ground’s New Reality Show Warrior Island 2Health News:Bodybuilding.com Partners with Global Proving Ground’s New Reality Show Warrior Island 3Health News:Workshops Offered To Identify Underlying Challenges That Put Strain On Relationships 2Health News:Changing cancer's environment to halt its spread 2Health News:Changing cancer's environment to halt its spread 3
... of the American College of Cardiology during,ceremonies at ... in Chicago, CHICAGO, April 1, 2008 ... Bluhm Cardiovascular Institute,of Northwestern Memorial Hospital, and Goldberg ... was recognized by the,American College of Cardiology (ACC) ...
... Leading consumer,employer and labor organizations today announced ... and health insurers on principles,to guide how ... the,information to consumers., The "Patient Charter ... announced today creates a national set of ...
... from people up to 75 had similar survival rates to ... News) -- People up to the age of 75 should ... National Eye Institute-funded study. , The researchers found that tissue ... success rate (86 percent) as corneas from donors aged 12 ...
... Your friend can eat whatever she wants and still fit into ... look at that chocolate cake. Before you sign up for Weight ... at some recent research from Tel Aviv University and save yourself ... to do with rigorous exercise and abstaining from sweets than it ...
... A new study has found that an x-ray dye ... prevent renal injury during percutaneous coronary intervention (PCI) in ... it made no difference in the need for dialysis ... the Contrast Media and Nephrotoxicity Following Coronary Revascularization by ...
... Speaker Denny Chipollini inspires others to hit the trails for ... Valley Forge Revolutionary 5-mile ... most people would,consider tragedies, 55-year-old Skippack, Pa., resident Denny Chipollini,considers ... loss of his leg in a near-fatal car accident and ...
Cached Medicine News:Health News:Robert Bonow, MD Honored for Outstanding Service by the American College of Cardiology 2Health News:Robert Bonow, MD Honored for Outstanding Service by the American College of Cardiology 3Health News:Consumers, Health Care Purchasers, Physicians, and Health Insurers Announce Agreement on Principles to Guide Physician Performance Reporting 2Health News:Consumers, Health Care Purchasers, Physicians, and Health Insurers Announce Agreement on Principles to Guide Physician Performance Reporting 3Health News:Consumers, Health Care Purchasers, Physicians, and Health Insurers Announce Agreement on Principles to Guide Physician Performance Reporting 4Health News:Consumers, Health Care Purchasers, Physicians, and Health Insurers Announce Agreement on Principles to Guide Physician Performance Reporting 5Health News:Study Finds Older Corneas Suitable for Transplantation 2Health News:The lean gene 2Health News:Iso-osmolar X-ray dye falters in PCI study 2Health News:Iso-osmolar X-ray dye falters in PCI study 3Health News:For Inspiring Amputee It's No Excuses, No Limits 2
(Date:5/21/2013)... , 21. Mai 2013 ... die die Firmen OMNIlife science® Inc., Enztec Ltd. ... hat zwei neue, erfahrene Mitglieder in die ... , eine erfahrene Führungspersönlichkeit aus der Orthopädie, ... David Johnson , anerkannter Experte ...
(Date:5/21/2013)... CEO of Mammotome, a division of Devicor Medical Products, has ... Cincinnati chapter of the Association for Corporate Growth ... who is also a breast cancer survivor, led the purchase ... 2010. Daulton will be presented with the award at the ... May 22. The ACG Deal Maker Awards program ...
(Date:5/21/2013)... and PHILADELPHIA , May 21, 2013 ... its new corporate image and impressive new product developments at ... . "After ten years of unerring focus on product ... felt the need to mark the occasion," said founding director ... we have some interesting developments of benefit to our clients ...
Breaking Medicine Technology:Orthopaedic Synergy Inc. meldet bedeutenden Zuwachs im Vorstand 2Orthopaedic Synergy Inc. meldet bedeutenden Zuwachs im Vorstand 3Tom Daulton, Mammotome CEO, Named ACG Dealmaker of the Year 2Tom Daulton, Mammotome CEO, Named ACG Dealmaker of the Year 3Pi2 Solutions' 10th Anniversary Heralds New Corporate Image as Platinum Sponsor of SLA PHT Meeting in Philadelphia 2Pi2 Solutions' 10th Anniversary Heralds New Corporate Image as Platinum Sponsor of SLA PHT Meeting in Philadelphia 3
... As the diverse areas of healthcare forge ... must medical technologies reform to solve several challenges ... and restraints into an interpretable roadmap, Frost & ... and Outcomes-Oriented Healthcare Delivery, 2010 to 2012 ...
... 2012 Tarsa Therapeutics today announced it has entered ... the bulk manufacture of its OSTORA™ oral recombinant salmon ... in QS Pharma,s state-of-the-art facility in Pennsylvania, will be ... This new agreement builds on the continuing collaboration between ...
Cached Medicine Technology:Frost & Sullivan's Advanced Medical Technologies Research Tracks Opportunities in Markets Influenced by Dynamic Care Pathways 2Frost & Sullivan's Advanced Medical Technologies Research Tracks Opportunities in Markets Influenced by Dynamic Care Pathways 3Tarsa Therapeutics Signs Commercial Supply Agreement for its Ostora™ Oral Calcitonin Product With QS Pharma 2Tarsa Therapeutics Signs Commercial Supply Agreement for its Ostora™ Oral Calcitonin Product With QS Pharma 3
... two wells: a positive control ... 3308 in simulated sputum and ... albus subsp. albus ATCC ® ... Stain Control Slides should be ...
... Plate Capability The Equalizer 384 includes ... and equal tip spacing, choice of two software ... addition, this model allows you to evenly space ... accessing many gels and for use with 384 ...
... 384 Well Plate Capability The Equalizer ... original Equalizerexpandable and equal tip spacing, choice of ... capabilities. In addition, this model allows you to ... loading and accessing many gels and for use ...
... A lower cost alternative to Equalizers, the patented ... between two different vessel configurations. With the push ... be quickly and easily adjusted for test tubes ... Ergonomic Design for Unparalleled Comfort Pick one ...
Medicine Products: