Navigation Links
Moffitt Cancer Center researchers find acidic pH microenvironments in tumors aid tumor cell survival
Date:9/5/2012

Researchers at Moffitt Cancer Center and colleagues at the University of South Florida and Wayne State University have discovered that tumor cell survival relies on adaptation to acidic conditions in the tumor microenvironment. Their research investigating the effects of acidity on breast and pancreatic cancer cell lines revealed the importance of autophagy in acidic microenvironments and suggests that a successful treatment strategy might be based on this autophagic dependence.

The study appears as the cover story for the Aug. 15 issue of Cancer Research, a publication of the American Association for Cancer Research.

"Cancer progression is a multistep process strongly influenced by the physical properties of the tumor microenvironment," said Robert J. Gillies, Ph.D., corresponding author of the study and chair of Moffitt's Department of Cancer Imaging and Metabolism. "Both low oxygen and high acidity can be cytotoxic. Our research suggests that adaptation to these stressful conditions involves autophagy allowing cancer cells to survive, proliferate and eventually metastasize to secondary sites."

According to the authors, not much is known about cell survival mechanisms under acidic conditions, but it has been demonstrated that acidosis can alter gene expression leading to cell types that are adapted for growth and survival in low pH conditions. Identifying low pH survival mechanisms would "give further insight into tumor progression and potentially introduce novel therapeutic strategies," researchers said.

In this study, the researchers tested cancer cell lines under acidic conditions to learn more about autophagy and cellular adaptation. They noted that normal cells in the acidic environment can respond to acidic stress by increasing cell death pathways, thus introducing the need for survival and adaptive mechanisms by cancer cells.

The researchers also noted that their experiments were carried out under
'/>"/>

Contact: Kim Polacek
kim.polacek@moffitt.org
813-745-7408
H. Lee Moffitt Cancer Center & Research Institute
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Review finds some evidence for chemo brain in breast cancer survivors, Moffitt Cancer Center says
2. Moffitt Cancer Center researchers and colleagues identify PHF20, a regulator of gene P53
3. Moffitt Cancer Center melanoma expert reviews unique adverse events with newly approved drug
4. Moffitt Cancer Center researchers validate molecular signature to predict radiation therapy benefit
5. Moffitt Cancer Center researchers discover how cancer cells hijack a mechanism to grow
6. Attitudes toward outdoor smoking ban at moffitt Cancer Center evaluated
7. Moffitt Cancer Center researcher & colleagues test new drug for patients with neuroendocrine tumors
8. Moffitt Cancer Center researchers find potential key to new treatment for mantle cell lymphoma
9. Moffitt Cancer Center study validates activity of rare genetic variant in glioma
10. Moffitt researchers find cutaneous human papillomavirus infection a risk factor for skin cancer
11. Moffitt Cancer Center researchers test drug combinations to prevent graft vs. host disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2015)... Washington, DC (PRWEB) April 17, 2015 ... the HHT Diagnoses and Treatment Act HR 1849 in ... improve diagnosis rates and treatment for patients with the ... introduced in the past, would be the first to ... diagnoses and appropriate treatment of hereditary hemorrhagic telangiectasia. This ...
(Date:4/17/2015)... Fla. (PRWEB) April 17, 2015 Most ... of dental restoration units are made overseas by foreign ... Additionally, domestic labs remain unregulated in more than 40 ... The National Association of Dental Laboratories has ... to raise awareness among patients about the consequences that ...
(Date:4/17/2015)... NY (PRWEB) April 17, 2015 ... with a multicenter team of U.S. and Venezuelan ... bacteria yet in humans among an isolated tribe ... of Venezuela. Bacterial diversity in the Yanomami, previously ... to be nearly double that of people living ...
(Date:4/17/2015)... Compare-autoinsurance.org has released a new blog ... auto insurance quotes . , The online environment ... their cars. Drivers should always compare multiple car insurance ... market is a competitive one, which means that customers ... , It is now possible to compare online car ...
(Date:4/17/2015)... Nomedexamlifeinsurance.com has released a new blog post ... smokers . , Smoking is linked to numerous diseases ... will charge smokers more money for life insurance plans. ... insurance and can qualify for advantageous offers. , ... than for non-smokers. Comparing quotes is the best method ...
Breaking Medicine News(10 mins):Health News:House Representatives Introduce Bill to Fight Genetic Disease 2Health News:National Association Urges Transparency in Dental Industry 2Health News:Mount Sinai Scientists Find Unprecedented Microbial Diversity in Isolated Amazonian Tribe Previously Unexposed to Antibiotics or Processed Foods 2Health News:Mount Sinai Scientists Find Unprecedented Microbial Diversity in Isolated Amazonian Tribe Previously Unexposed to Antibiotics or Processed Foods 3Health News:The Best Auto Insurance Quotes Are Available Online! 2Health News:Life Insurance Quotes for Smokers Available Online 2
... , , , , ... in the European Journal of Clinical Microbiological Infectious Diseases ... agent in topical wound care, particularly where antibiotic resistance is an ... activity of medical-grade Leptospermum honey: antibacterial spectrum, resistance and ...
... , , , ... could tell people,s personalities based on the types of drink they enjoy. ... described as sweet and indulgent, while someone who likes fruity drinks could ... Los Angeles-based BLD & Grace Restaurants says the same could be said ...
... non-small-cell lung cancer study , MONDAY, July 27 (HealthDay News) ... for people with stage 3A non-small-cell lung cancer, a new ... cannot cure the disease because it has spread to the ... Non-small-cell lung cancer accounts for about 80 percent of lung ...
... a grant of over 39,000 from the charity Deafness Research ... deafness in children and adults and the development of therapies ... of other tumours are caused by mutations affecting a protein ... of cell types including Schwann cells in the nervous system. ...
... 2009) -- For the 29,000 patients in the United States ... treatment that has been shown to improve survival. But for ... in their DNA means that this treatment could result in ... to a high risk of bacterial infection and possible ...
... enzyme, endothelin converting enzyme-2 (ECE-2), may cause the decrease ... disease and contribute to progression of the disease. ... Scholar and colleagues at the University of Bristol,s Dementia ... 2009] of the American Journal of Pathology. ...
Cached Medicine News:Health News:Paper Highlights Antimicrobial Effectiveness of Medical-Grade Honey in Topical Wound Care 2Health News:Personality in a Cup 2Health News:Personality in a Cup 3Health News:Radiation Plus Chemo a Good Option in Lung Cancer 2Health News:Grant for brain tumor and deafness research 2Health News:Genetic testing may be valuable in treating colorectal cancer 2Health News:Blood flow in Alzheimer's disease 2
(Date:4/16/2015)... 16, 2015 Mallinckrodt plc (NYSE: ... announced that it has completed its acquisition of ... $2.3 billion. The Ikaria acquisition extends Mallinckrodt,s footprint ... into neonatal critical care with INOMAX ® ... a highly vulnerable patient population. It also accelerates ...
(Date:4/16/2015)... , April 16, 2015  Diplomat Pharmacy, Inc. ... Shannon Beltrand to their senior leadership team as ... be responsible for securing and properly monitoring Diplomat,s data, ... both internally and externally. Additionally, she will play key ... "We are very excited to have someone ...
(Date:4/16/2015)... YORK , April 16, 2015 An ... additional way to generate trimers from the major HIV ... could benefit future clinical development of HIV vaccine candidates ... the critical target on the surface of HIV for ... an important platform for AIDS vaccine discovery, says ...
Breaking Medicine Technology:Mallinckrodt Completes Acquisition Of Ikaria 2Mallinckrodt Completes Acquisition Of Ikaria 3Mallinckrodt Completes Acquisition Of Ikaria 4Mallinckrodt Completes Acquisition Of Ikaria 5Diplomat Names Shannon M. Beltrand as New CISO 2New Method Holds Promise for HIV Vaccine Development 2
Designated most popular model or size. 4 mm wide tip....
Double-ended. Blunt and semi sharp 5 mm tips. Designated most popular model or size....
Double-ended. Semi sharp. Curved 3 mm tips. Angled right and left....
Double-ended. 6 mm x 9 mm and 6 mm x 11 mm tips....
Medicine Products: