Navigation Links
Moffitt Cancer Center researchers discuss new frontiers in breast cancer screening
Date:4/4/2013

Researchers at Moffitt Cancer Center predict that advancements in breast cancer screening will need a personalized touch because mammography is not a "one strategy fits all" technology.

Their review "Beyond Mammography: New Frontiers in Breast Cancer Screening" appears in the April 4 issue of The American Journal of Medicine.

"Although mammography remains the gold standard for breast cancer screening, there is increasing awareness that there are subpopulations of women for whom mammography is limited because of its reduced sensitivity based on an individual's breast density and other factors," said study lead author Jennifer S. Drukteinis, M.D., assistant member in Moffitt's Department of Diagnostic Imaging.

The writers refer to a controversial disagreement on mammography screening issues. In 2009, the U.S. Preventive Services Task Force, a panel of health care professionals charged with reviewing published research and making health care policy recommendations, issued guidelines that women should get mammograms every two years starting at age 50. They recommended against screening before 50. Their recommendation generated great controversy, even outrage, because of a well-established convention recommending mammography screening beginning at 40 and, for those with a first-degree relative with breast cancer, screening should start a decade before that relative's age at diagnosis.

"At present, the task force is the only group or consensus panel in the United States recommending breast cancer screenings to begin at age 50," said study co-author Blaise P. Mooney, M.D., an assistant member in Moffitt's Department of Diagnostic Imaging. "There is, however, clear evidence that mammography detects early breast cancers in this population. Data suggest that large-scale screening reduces mortality."

As effective as mammography has been, the authors consider it an imperfect screening tool.

The sensitivity of mammography is highly variable, the authors point out. The effectiveness for women with fatty breast tissue is as high as 98 percent while the effectiveness for women with dense breasts can be as low as 36 percent. Women who undergo annual mammography may still present with cancers found only on physical examination, they said. Additionally, some studies suggest that radiation exposure may contribute to an increase in breast cancer incidence in high-risk populations.

More successful breast cancer screening requires increased sensitivity and specificity while limiting costs and radiation burden, the authors recommended.

They also suggested that optimal patient care will require a new screening paradigm with patient-specific strategies tailored to risk based on family history, age, genetic profiles and breast density.

"The sensitivity of mammography is inversely proportional to breast density," explained Mooney. "Owing to decreased sensitivity in women with dense breast tissue, but with attention to radiation concerns and a high rate of false positives, breast imagers are adapting with new technologies."

According to the authors, those new technologies include low-dose mammography, contrast-enhanced mammography (evaluates blood flow in the breast), automated whole breast ultrasound, molecular imaging, MRI and tomosynthesis (multiple mammographic "slices" through the breast, similar to a CT scan).

"Decreases in mortality have not been proved with any of these emerging technologies," Drukteinis said. "Once more, it is unlikely that any of these new technologies will replace mammography. The role of these new technologies is primarily as an adjunct to screening mammography and can be used in a combination tailored to the individual's risk factors and breast density, with the goal of maximizing sensitivity and specificity."

"Given the heterogeneity of the human population, a perfect imaging technology for breast cancer screening will likely never be found. In fact, because of this heterogeneity, the very concept of one strategy fits all may be outmoded," Drukteinis said.

The authors agree that new technologies will be increasingly personalized, integrating patient-specific and age-dependent factors of cancer risk "with selective application of specific screening technologies best suited to the woman's age, risk and breast density."


'/>"/>

Contact: Kim Polacek
kim.polacek@moffitt.org
813-745-7408
H. Lee Moffitt Cancer Center & Research Institute
Source:Eurekalert

Related medicine news :

1. Moffitt Cancer Center researchers say 1 specific microrna promotes tumor growth and cancer spread
2. Moffitt Researchers help lead international efforts that find new genetic links to ovarian cancer
3. Moffitt researchers analyze HPV vaccination disparities among girls from low-income families
4. Moffitt Cancer Center researchers design small molecule to disrupt cancer-causing protein
5. Genetic risk strategies needed for young, black, female breast cancer patients, Moffitt study shows
6. Moffitt Cancer Center researchers study use of dasatinib for patients with high-risk MDS
7. Cancer doesnt change young girls desire to have children, Moffitt Cancer Center study shows
8. Surgery and radiation improve survival for metastatic gastric cancer patients, Moffitt study shows
9. Moffitt researchers say silencing of retinoblastoma gene regulates differentiation of myeloid cells
10. Moffitt researchers find potential new therapeutic target for treating non-small cell lung cancer
11. Moffitt Cancer Center researchers develop automated breast density test linked to cancer risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/18/2017)... Mich. USA; SAN JOSE, Calif, USA; and SHANGHAI, China – ... ... (PRWEB) January 18, 2017 -- Global public health organization ... reduce arsenic V (pentavalent arsenic) to NSF/ANSI 53: Drinking Water ... drinking water treatment units. This certification verifies that MicroCeramics’ NanoNose ...
(Date:1/18/2017)... ... 18, 2017 , ... The V Foundation for Cancer Research, a top-rated cancer ... and fundraising team, to compete in the Boston Marathon on April 17. From ... world’s oldest annual marathon to join Team V and support the Foundation’s mission to ...
(Date:1/18/2017)... ... January 18, 2017 , ... PrideStaff, a ... President of Franchise Development, Paula Turner Pizarro, was recently featured on Fox Business ... the insights of top business leaders from across the globe, provides viewers an ...
(Date:1/18/2017)... , ... January 18, 2017 , ... ... asset protection and financial planning services to families and business owners in the ... aimed at supporting children with developmental disabilities. , The Lakemary Center is a ...
(Date:1/18/2017)... Alexandria, VA (PRWEB) , ... January 18, 2017 , ... ... services in family, cosmetic and implants dentistry. His modern dental practice has two convenient ... Qureshi as a 2017 Top Rated Dentist for the Alexandria area. This ...
Breaking Medicine News(10 mins):
(Date:1/18/2017)... 18, 2017 Safe Rx LLC and Good ... in Loveland, Colorado , today announced ... selected Good Day locations.     "Patients with ... for secure storage," said Milton Cohen , President ... price of a cup of coffee, you can protect ...
(Date:1/18/2017)... The report " Automated Breast Ultrasound System (ABUS) Market Size By ... Diagnostic Imaging Centers), Industry Analysis Report, Regional Outlook (U.S., Canada ... Germany , UK, France , Spain ... China , Japan , India , ... Arabia , UAE, South Africa ), Application Growth Potential, ...
(Date:1/18/2017)... --  Seno Medical Instruments, Inc. , the leader in ... development of an opto-acoustic (OA/US) imaging device, today announced ... of Engineering. Mr. Miller previously served as the Vice ... in Bothell, Washington . Mr. Miller ... the development of innovative medical imaging products that affect ...
Breaking Medicine Technology: