Navigation Links
Moffitt Cancer Center researchers develop and test new anti-cancer vaccine
Date:6/8/2012

Researchers at Moffitt Cancer Center have developed and tested in mice a synthetic vaccine and found it effective in killing human papillomavirus-derived cancer, a virus linked to cervical cancers among others. The research was published in a recent issue of Cancer Immunology, Immunotherapy.

"Vaccines for cancer can be good alternatives to conventional therapies that result in serious side-effects and are rarely effective against advanced disease," said Esteban Celis, M.D., Ph.D., senior member and professor in Moffitt's Immunology Program. "The human papillomavirus, or HPV, is known to cause 99 percent of cervical cancers and annually causes more than 250,000 deaths worldwide." In addition, HPV is the causative agent of a large proportion of head and neck and genital cancers.

Although two approved prophylactic vaccines against strains of HPV that cause cervical cancer are now in wide use as a measure to prevent HPV infections, these vaccines cannot be used to treat HPV-induced cancers. Thus, there is a need to develop therapeutic vaccines for HPV-related tumors.

In an effort to find an effective HPV-cancer vaccine that would eliminate existing HPV-induced cancer, Celis and Kelly Barrios-Marrugo, Ph.D., of the University of South Florida College of Medicine's Molecular Medicine program, designed a peptide vaccination strategy called TriVax-HPV.

The TriVax vaccine strategy was designed to generate large numbers of cytotoxic T-cells that would seek out the proteins preferentially expressed in the tumors. The HPV16-E6 and E7 proteins function as oncogenic proteins inducing cancer. Thus, according to Celis and Barrios-Marrugo, a vaccine targeting these viral proteins is an "ideal candidate" to create strong immune responses, with the additional benefit of not generating autoimmune-related pathologies.

When they tested their vaccine in mice with HPV16-induced tumors, they found that TriVax containing a small synthetic fragment (peptide) of the E7 protein "induced tumor clearance in 100 percent of the treated mice" while the unvaccinated mice with HPV-induced tumors had their tumors grow "at a fast rate."

"Although the magnitude of the T-cell responses achieved with TriVax in mice is impressive," Barrios-Marrugo said," we do not know whether similar effects can be accomplished in humans."

Celis and Barrios-Marrugo point out that current therapies for cervical cancer can be devastating, highly toxic and associated with a 10 percent chance of recurrence. Additionally, a significant proportion of women in the Third World will not receive the approved prophylactic vaccine to prevent HPV infection and, thus, will continue at high risk for cervical and other cancers related to HPV.

"We believe that these studies may help to launch more effective and less invasive therapeutic vaccines for HPV-caused malignancies," concluded the authors.


'/>"/>

Contact: Patty Kim
patty.kim@moffitt.org
813-745-7322
H. Lee Moffitt Cancer Center & Research Institute
Source:Eurekalert

Related medicine news :

1. Moffitt Cancer Center researchers identify drivers of sarcoma growth and survival
2. Researchers creating designer lymph nodes based on Moffitts Total Cancer Care initiative
3. Moffitt researcher awarded GE grant to develop tool to detect breast cancer metastasis genetic risks
4. Moffitt researcher publishes book on nutritional management of cancer treatment effects
5. Moffitt researchers find adolescents with cancer concerned about their future reproductive health
6. Moffitt Cancer Center researchers working at frontiers of melanoma research
7. Moffitt Cancer Center researchers: Quality of life as important as quantity of life
8. Moffitt researchers find cancer therapies affect cognitive functioning among breast cancer survivors
9. Study sheds new light on role of genetic mutations in colon cancer development
10. Child CT Scans Might Up Risk of Brain Cancer, Leukemia
11. 2-1-1 could be effective tool in fighting cancer disparities
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/8/2016)... ... December 08, 2016 , ... STATEN ... been recognized for adherence to the highest standards of trauma, maternity, cancer and ... the center's president and CEO, Dr. Daniel Messina. , Among the recognitions, the ...
(Date:12/8/2016)... ... December 08, 2016 , ... Vida Health, the digital ... B led by Canvas Ventures . Other investors include Nokia Growth Partners (NGP) ... platform to serve more consumers who are managing chronic conditions or simply ...
(Date:12/8/2016)... FL (PRWEB) , ... December 08, 2016 , ... Coppin ... business owners and families in and around the Cape Coral area, is embarking on ... Chapin Food Bank of Southwest Florida. , The Harry Chapin Food Bank of Southwest ...
(Date:12/7/2016)... , ... December 07, 2016 , ... ... Medicine will have the unique opportunity to get hands-on experience in an ... school students an immersive experience to gain invaluable, real-life medical skills that are ...
(Date:12/7/2016)... ... December 07, 2016 , ... Wavelink, an industry ... Control through a new partnership with Splashtop Inc. This remote control for Android ... to help businesses maximize their uptime and productivity. , Wavelink offers powerful enterprise ...
Breaking Medicine News(10 mins):
(Date:12/8/2016)... 8, 2016   TriNetX , the health ... Hospital signed a membership agreement to join ... of new cures. The TriNetX network ... million patients globally, biopharmaceutical companies and contract research ... protocol design, site selection, patient recruitment, and collaborative ...
(Date:12/8/2016)... Dec. 8, 2016  A new study by a ... use of opioid therapy to treat chronic pain is ... of more harmful consequences, including death. Palliative ... Zankhana Mehta , M.D., authored the study which ... opioid therapy. The study was published in the December ...
(Date:12/8/2016)... -- Mederi Therapeutics Inc . hat die behördliche Zulassung durch die ... Refluxerkrankung (GERD) – in China angekündigt. ... ... Live Stretta procedure performed and broadcast during the ... at Wuhan Union Hospital ...
Breaking Medicine Technology: