Navigation Links
Moffitt Cancer Center researcher receives $2.1 million grant from NCI for answering 'Provocative Question'
Date:9/17/2012

TAMPA, Fla. (Sept. 17, 2012) Robert A. Gatenby, M.D., senior member of Moffitt Cancer Center's Department of Diagnostic Imaging and Integrated Mathematical Oncology, and his colleagues have received a four-year, $2.1 million grant from the National Cancer Institute to carry out pre-clinical research focused on cancer cell drug resistance. Researchers will examine cancer's evolutionary mechanisms of drug resistance and focus on prevention strategies.

The grant (CA170595-01) stems from the NCI's "Provocative Questions" Project. Researchers from across the country were asked to respond to 24 provocative questions in hopes of stimulating the NCI's research communities. The questions focused on specific advances in understanding cancer and cancer control, broad issues on the biology of cancer, the likelihood of progress in less than a decade, and ways to overcome obstacles to achieving long-term goals.

Gatenby answered question 21: "Given the appearance of resistance in response to cell killing therapies, can we extend survival by using approaches that keep tumors static?"

According to the NCI, the question addresses the relationship between drug resistance in cancer treatment and the Darwinian Theory about natural selection and adaptation to selective environmental pressures. In the case of cancer cells, the environmental pressure refers to chemotherapy and survival means becoming resistant to the drugs aimed at killing them.

The question also asks whether an evolutionary approach can create a balance in tumor cells by not creating resistance through attempts to kill cells but, rather, provide an environment where selection forces are weak. Speculation is that under weak selective forces, cancer cells can live in a form of balance, not dying or becoming drug resistant.

Gatenby's approach to treatment is through a term he and his research team coined adaptive therapy.

"Adaptive therapy shifts the treatment pa
'/>"/>

Contact: Kim Polacek
kim.polacek@moffitt.org
813-745-7408
H. Lee Moffitt Cancer Center & Research Institute
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Moffitt cancer center researchers find novel predictor for MDS progression risk
2. Moffitt researchers say race affect likelihood of finding suitable stem cell donor
3. Moffitt Cancer Center researchers study childhood melanoma characteristics
4. Moffitt Cancer Center researchers find acidic pH microenvironments in tumors aid tumor cell survival
5. Review finds some evidence for chemo brain in breast cancer survivors, Moffitt Cancer Center says
6. Moffitt Cancer Center researchers and colleagues identify PHF20, a regulator of gene P53
7. Moffitt Cancer Center melanoma expert reviews unique adverse events with newly approved drug
8. Moffitt Cancer Center researchers validate molecular signature to predict radiation therapy benefit
9. Moffitt Cancer Center researchers discover how cancer cells hijack a mechanism to grow
10. Attitudes toward outdoor smoking ban at moffitt Cancer Center evaluated
11. Moffitt Cancer Center researcher & colleagues test new drug for patients with neuroendocrine tumors
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/22/2014)... October 22, 2014 Hay House is pleased ... Addiction and Upgrade Your Life (Paperback; $10.82) written by the ... & Recovery. This book is meant to help readers ... life of recovery. , Recovery 2.0 is not the ... Recovery 2.0 is a guide for what comes next. ...
(Date:10/22/2014)... 22, 2014 Healthcare professionals who ... continuing education at home or on-the-go via laptops, ... 20 brand new, premium Seminar-on-Demand CE courses. The ... over 2,000 hours of CE course ... educational experience. With such a diverse library, there’s ...
(Date:10/22/2014)... 2014 Richard Carlson, Managing Partner of ... with over 25 years experience. Mr. Carlson is ... areas related to EDI, B2B Commerce, RFID and Internet/Intranet ... Advisory Board member for Pharmaceutical Commerce Magazine and a ... Group is a management and technology consulting firm focused ...
(Date:10/22/2014)... sisters in high school have developed ways to measure ... use electronic stethoscopes, which electronically amplify body sounds, to ... heartbeats. Ilina, a senior at Port Huron Northern ... to detect early lung damage in people exposed to ... one breath cycle each from 16 smokers, 25 nonsmokers ...
(Date:10/22/2014)... HealthDay Reporter , MONDAY, Oct. 20, 2014 (HealthDay ... for health workers treating Ebola patients, now requiring full body ... at all times. The U.S. Centers for Disease Control ... Dallas nurses contracted Ebola while caring for the first ... Duncan. Nina Pham is currently being treated for her infection ...
Breaking Medicine News(10 mins):Health News:Hay House Announces The Official Release of Recovery 2.0: Move Beyond Addiction and Upgrade Your Life 2Health News:Hay House Announces The Official Release of Recovery 2.0: Move Beyond Addiction and Upgrade Your Life 3Health News:Top Provider of Continuing Education at Home Releases 20 New Online Courses 2Health News:Rich Carlson and Marc Duey to Hold Workshop at CBI’s Specialty Pharmacy and Distribution Networks Conference 2Health News:Teen Sisters Develop Ways to Measure Lung, Heart Damage 2Health News:CDC Tightens Rules on Caring for Ebola Patients 2Health News:CDC Tightens Rules on Caring for Ebola Patients 3
... by the Food & Drug Administration for the treatment of prostate ... A new study shows abiraterone acetate extends the lives of ... four months. The study in the May 26, 2011 issue of ... Thomas W. Flaig, MD, medical oncologist at the University of Colorado ...
... Calif. A woman,s risk of developing diabetes during pregnancy ... pregnant based on routinely assessed measures of blood sugar and ... the online issue of the American Journal of Obstetrics ... Kaiser Permanente Division of Research in Oakland, Calif., studied 580 ...
... traumatic stress with war-afflicted populations (veterans and civilians) and ... research professor in the department of psychology and the ... the University of Houston (UH), decided to study another ... eighth grade. "Teaching is a highly stressful ...
... , WEDNESDAY, May 25 (HealthDay News) -- Taken in ... the cholesterol-lowering medication Pravachol, appear to significantly raise blood ... is most apparent -- and concerning -- among diabetics, ... noted. "This interaction may affect as many as ...
... field, poised to take a crucial penalty kick, "I always had a ... do" says sports psychologist Antonis Hatzigeorgiadis. "I was setting the ball and ... of shots; then I had that thought striking me that it was ... he recalls, "and I did miss." Even then, he could see that ...
... Medications are the mainstay of treatment for epilepsy, but for ... many as 1 million in the U.S. drugs don,t ... as refractory or drug-resistant epilepsy, in which drugs can,t control ... last month, Dr. Christopher DeGiorgio, a UCLA professor of neurology, ...
Cached Medicine News:Health News:New drug treatment extends lives of men with prostate cancer 2Health News:Diabetes can be predicted 7 years before pregnancy with blood sugar and body weight 2Health News:New University of Houston research study links job stress in teachers to student achievement 2Health News:New University of Houston research study links job stress in teachers to student achievement 3Health News:Combo of Paxil, Pravachol May Raise Blood Sugar 2Health News:Combo of Paxil, Pravachol May Raise Blood Sugar 3Health News:Thoughts that win 2Health News:Unique nerve-stimulation treatment proves effective against drug-resistant epilepsy 2
(Date:10/22/2014)... and AUSTIN, Texas , ... PureMHC LLC today announced they have entered into ... antibody-based immunotherapies designed to target cancers. ... peptides displayed on the surfaces of tumor cells ... targets (PTTs), derived from proteins that play a ...
(Date:10/22/2014)... and SHANGHAI , Oct. 22, 2014 ... FMI ) and WuXi PharmaTech (Cayman) Inc. (NYSE: ... offer Foundation Medicine,s comprehensive genomic profiling to biopharmaceutical companies ... Under the terms of the collaboration, ... the laboratory component of Foundation Medicine,s FoundationOne® assay at ...
(Date:10/20/2014)... Oct. 20, 2014  ResMed (NYSE: ... ResMed Data Exchange program, a comprehensive suite of ... (HME) and other health care providers. ... to critical patient information. It integrates valuable sleep ... U-Sleep™ patient management platforms with customers, in-house or ...
Breaking Medicine Technology:Biotech Companies To Co-Discover And Co-Develop Antibodies Targeting Novel Phosphopeptide Tumor Targets 2Foundation Medicine and WuXi PharmaTech Announce Strategic Collaboration to Offer Best-in-Class Comprehensive Genomic Profiling in China 2Foundation Medicine and WuXi PharmaTech Announce Strategic Collaboration to Offer Best-in-Class Comprehensive Genomic Profiling in China 3Foundation Medicine and WuXi PharmaTech Announce Strategic Collaboration to Offer Best-in-Class Comprehensive Genomic Profiling in China 4Foundation Medicine and WuXi PharmaTech Announce Strategic Collaboration to Offer Best-in-Class Comprehensive Genomic Profiling in China 5ResMed Launches ResMed Data Exchange 2
... THE WOODLANDS, Texas, Sept. 30, 2011 David, a ... grandfather, felt too young to be diagnosed with prostate ... symptoms." David, under the advisement of his oncologist, decided ... first in a new therapeutic class known as autologous ...
... 30, 2011 The CyberKnife Coalition announced ... CyberKnife Robotic Radiosurgery System® have now been enrolled in ... prostate cancer patients treated with stereotactic body ... (RPCR), tracks clinical and functional outcomes of men with ...
Cached Medicine Technology:The US Oncology Network Affiliated Physicians at Forefront of Cutting-Edge Prostate Cancer Treatment 2The US Oncology Network Affiliated Physicians at Forefront of Cutting-Edge Prostate Cancer Treatment 3The US Oncology Network Affiliated Physicians at Forefront of Cutting-Edge Prostate Cancer Treatment 4First Prostate Cancer Registry for Robotic Radiosurgery Patients Enrolls More than 500 Men 2
The Optima III line of laparoscopic hand instruments provides a well-crafted set of instruments designed for strength and durability....
The Optima III line of laparoscopic hand instruments provides a well-crafted set of instruments designed for strength and durability....
The Optima III line of laparoscopic hand instruments provides a well-crafted set of instruments designed for strength and durability....
Inquire...
Medicine Products: