Navigation Links
Moffitt Cancer Center researcher receives $2.1 million grant from NCI for answering 'Provocative Question'
Date:9/17/2012

TAMPA, Fla. (Sept. 17, 2012) Robert A. Gatenby, M.D., senior member of Moffitt Cancer Center's Department of Diagnostic Imaging and Integrated Mathematical Oncology, and his colleagues have received a four-year, $2.1 million grant from the National Cancer Institute to carry out pre-clinical research focused on cancer cell drug resistance. Researchers will examine cancer's evolutionary mechanisms of drug resistance and focus on prevention strategies.

The grant (CA170595-01) stems from the NCI's "Provocative Questions" Project. Researchers from across the country were asked to respond to 24 provocative questions in hopes of stimulating the NCI's research communities. The questions focused on specific advances in understanding cancer and cancer control, broad issues on the biology of cancer, the likelihood of progress in less than a decade, and ways to overcome obstacles to achieving long-term goals.

Gatenby answered question 21: "Given the appearance of resistance in response to cell killing therapies, can we extend survival by using approaches that keep tumors static?"

According to the NCI, the question addresses the relationship between drug resistance in cancer treatment and the Darwinian Theory about natural selection and adaptation to selective environmental pressures. In the case of cancer cells, the environmental pressure refers to chemotherapy and survival means becoming resistant to the drugs aimed at killing them.

The question also asks whether an evolutionary approach can create a balance in tumor cells by not creating resistance through attempts to kill cells but, rather, provide an environment where selection forces are weak. Speculation is that under weak selective forces, cancer cells can live in a form of balance, not dying or becoming drug resistant.

Gatenby's approach to treatment is through a term he and his research team coined adaptive therapy.

"Adaptive therapy shifts the treatment pa
'/>"/>

Contact: Kim Polacek
kim.polacek@moffitt.org
813-745-7408
H. Lee Moffitt Cancer Center & Research Institute
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Moffitt cancer center researchers find novel predictor for MDS progression risk
2. Moffitt researchers say race affect likelihood of finding suitable stem cell donor
3. Moffitt Cancer Center researchers study childhood melanoma characteristics
4. Moffitt Cancer Center researchers find acidic pH microenvironments in tumors aid tumor cell survival
5. Review finds some evidence for chemo brain in breast cancer survivors, Moffitt Cancer Center says
6. Moffitt Cancer Center researchers and colleagues identify PHF20, a regulator of gene P53
7. Moffitt Cancer Center melanoma expert reviews unique adverse events with newly approved drug
8. Moffitt Cancer Center researchers validate molecular signature to predict radiation therapy benefit
9. Moffitt Cancer Center researchers discover how cancer cells hijack a mechanism to grow
10. Attitudes toward outdoor smoking ban at moffitt Cancer Center evaluated
11. Moffitt Cancer Center researcher & colleagues test new drug for patients with neuroendocrine tumors
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/10/2014)... The benefits of medical imaging far outweigh the ... Right Way, with The Right Radiation Dose. However, overuse ... Mayo Clinic is leading a collaborative effort to ensure ... published online in the Journal of Patient Safety ... Joint Commission, the Intersociety Accreditation Commission, and the Centers ...
(Date:7/10/2014)... For decades, health-conscious people around the globe have ... figuring this was one of the paths to good ... clinical trials of antioxidant supplements have repeatedly dashed the ... their cancer risk. Virtually all such trials have ... In fact, in several trials antioxidant supplementation has been ...
(Date:7/10/2014)... Men who experience hot flashes are unlikely to ... from their silent suffering if they are willing ... a Baylor University case study., After seven weeks of ... hot flashes following prostate cancer surgery showed a drastic ... impressive improvement in sleep quality, according to the study., ...
(Date:7/9/2014)... MA -- Vasectomy was associated with a small increased ... advanced or lethal prostate cancer according to a new ... researchers found that the association remained even among men ... of lethal cancer cannot be explained by diagnostic bias. ... date to look at the link between vasectomy and ...
(Date:7/9/2014)... cancer, researchers have uncovered mutations in a cell-signaling pathway ... knowledge may expand treatments for patients because drugs targeting ... are in clinical trials. , Reporting July 9 in ... (TCGA), including researchers at Washington University School of Medicine ... studied tumors from 230 patients with lung adenocarcinoma. , ...
Breaking Medicine News(10 mins):Health News:Mayo Clinic calls for standardization of safe imaging protocols for children 2Health News:How antioxidants can accelerate cancers, and why they don't protect against them 2Health News:Men's hot flashes: Hypnotic relaxation may ease the discomfort men don't talk about 2Health News:Men's hot flashes: Hypnotic relaxation may ease the discomfort men don't talk about 3Health News:Men's hot flashes: Hypnotic relaxation may ease the discomfort men don't talk about 4Health News:Vasectomy may increase risk of aggressive prostate cancer 2Health News:Lung cancer study hints at new treatments 2
... CHICAGO, June 24 Bally Total Fitness Holding,Corporation today ... its Chief Executive Officer, effective July 1. Mr. Sheehan ... Directors., Mr. Sheehan, age 46, served as the ... serving as Chief Operating Officer, Mr. Sheehan,served as Executive ...
... control symptoms better, studies show , , TUESDAY, June 24 ... delivery system for an older drug appear to hold ... In the first study, patients taking the drug SLV308 ... tremors and slowness of movement. The results also indicate ...
... announced today Reproductive Health Matters , May 2008 ... Promoting Sexual and Reproductive rights". Under conditions of global ... growing numbers of refugees and internally displaced persons (IDPs) ... right to have rights,. By the end of ...
... Devices known as brain-machine interfaces could someday be ... prosthetic limbs with just their thoughts. Now, University of ... devising a way for computerized devices not only to ... with the brain as it learns. , Instead of ...
... but doing little to ... within the facility, CHICAGO, June 24 The American ... survey asking 1,000 women,their opinions on medical spas. Findings revealed ... customers of these facilities.,Yet half of those women are compromising ...
... The Rehabilitation Institute,of Chicago and MediCom Worldwide, Inc. ... July 18th and 19th. The meeting will be ... University in Chicago., This year, the conference ... scientific agenda will focus on the latest information,issues, ...
Cached Medicine News:Health News:Bally Total Fitness Announces New Chief Executive Officer 2Health News:New Hope for Parkinson's Patients 2Health News:May 2008 issue on conflict and crisis settings: Promoting sexual and reproductive rights 2Health News:Researchers develop neural implant that learns with the brain 2Health News:Researchers develop neural implant that learns with the brain 3Health News:Millennials' Medspa Influence 2Health News:3rd Annual Conference on Pain Jointly Sponsored By Rehabilitation Institute of Chicago and MediCom Worldwide, Inc. 2
(Date:1/15/2014)... , January 15, 2014 BreedIT Corp ... exclusive worldwide distributor of highly sophisticated agro-breeding solutions for ... 7, 2014, the Company,s board of directors appointed chemistry ... as its new member of the board. ...
(Date:1/15/2014)... Jan. 15, 2014  In an unprecedented effort to curb the spread ... and other transport vehicles, an advanced and portable UV germicidal lamp ... the first time. In order to prevent EMS ... pathogens, West Palm Beach Fire Rescue is ...
(Date:1/15/2014)... WOONSOCKET, R.I. , Jan. 15, 2014 MultiCell ... has filed a U.S. provisional patent application concerning composition ... formulations to achieve targeted tumor cell death.  ... very small noncoding double stranded RNA molecules (VSRNAs) which ...
Breaking Medicine Technology:BreedIT (OTC: BRDT) Appoints Chemistry and Pharmaceutical Industry Expert Dr. Ben-Zion Weiner to Its Board of Directors 2BreedIT (OTC: BRDT) Appoints Chemistry and Pharmaceutical Industry Expert Dr. Ben-Zion Weiner to Its Board of Directors 3Superbugs No Longer Ride In Rescue Vehicles 2MultiCell Technologies Files Patent Application Covering New Class of RNA Therapeutics 2MultiCell Technologies Files Patent Application Covering New Class of RNA Therapeutics 3
Ethicon, medium clip size, 10mm, rotatable take apart...
Solid phase capture sandwich ELISA assay using a microwell format....
The C-Reactive Protein (CRP) assay is used for the quantitative analysis of C-reactive protein in human serum and plasma. Kit is for use with the Abbot Laboratories Aeroset, ARCHITECT c8000 or ARCHI...
... broad menu clinical chemistry analyzer designed for ... Care givers can now perform routine multi-chemistry ... minute of hands-on time. Complete panel results ... expensive laboratory analyzers are available in under ...
Medicine Products: