Navigation Links
Modulated radiotherapy can cut treatment time for cancer of the rectum without increasing toxicity
Date:6/16/2008

Application of modulated radiotherapy in the treatment of bowel cancer can enhance the results obtained by means of other conventional therapies. The technique has managed to apply the radiation in a way most adapted to the tumoral volume and risk areas, while minimising irradiation to healthy tissue. This radiotherapy procedure involves the administration of higher daily doses of radiation but with a total dose equivalent to conventional ones. In this way the treatment time is cut by 30%, without a rise in side effects and with very high rates of pathological response.

These were the results of the study undertaken by a team of doctors at the University Hospital of Navarra, recently published in the specialist scientific journal, "International Journal of Radiation Oncology, Biology, Physics" of the American Society for Therapeutic Radiotherapy and Oncology. Involved in the research was a medical team from the area of digestive system tumours, led by Doctor Jos Javier Aristu, specialist at the Oncological Radiology Service. The article in the North American journal is the first published in the world giving clinical results from the application of preoperational modulated radiotherapy in tumours of the rectum.

Novelty for cancer of the rectum

IMRT (Intensity-Modulated Radiation Therapy) is a radiotherapy technique in which the administration of the radiation doses for the patient is effected by means of a lineal accelerator equipped with a system of multilaminas. Depending on the characteristics of the region that has to be irradiated, the planning system is capable of adapting high radiation doses to the shape of the target volume, enabling adjustments to be made to the morphology of the area to be treated in an individualized manner.

To date, the application of this procedure had been fundamentally limited to tumours located in the head, neck and prostrate gland. "This technique had been used in more confined tumours, more limited and smaller. We have now also begun to apply it to tumours of the rectum given that the conventional treatment, combining chemotherapy and radiotherapy, may cause high levels of toxicity", explained Doctor Aristu.

The main goal in administering modulated radiotherapy in the treatment of cancer of the rectum, lies in excluding the greatest possible proportion of healthy tissue from the field of radiation, mainly the intestines, bladder and the healthy section of the rectum. We have shown that treatment using conventional radiotherapy and chemotherapy simultaneously causes about a 30% enteritis rate (inflammation of the intestine). However, in the study, we observed that the application of modulated radiotherapy reduces the rate of enteritis practically to the minimum in the patient who is being treated for bowel cancer. Moreover, on limiting the radiation to the tumoral mass and thus affecting healthy tissue less, it was possible to increase the daily dosage and cut the overall treatment time by approximately 30%, while the total dose administered is equivalent to two conventional treatments.

Study in phase I-II

This research, initially undertaken with 20 patients with cancer of the rectum, is in study phase I-II, the main purpose of which is to find the highest dose that can be applied using modulated radiotherapy in combination with chemotherapy. According to Doctor Aristu, the research showed for the first time that a radiation dose equivalent to that administered using conventional techniques can be applied using IMRT in less time and with very promising rates of pathological response.


'/>"/>

Contact: Irati Kortabitarte
iratik@elhuyar.com
34-943-363-040
Elhuyar Fundazioa
Source:Eurekalert

Related medicine news :

1. Internal radiotherapy better than external for quality of life in endometrial cancer patients
2. Acupuncture does not reduce radiotherapy-induced nausea, but patients believe it does
3. Cancer researchers seek safe reduction of radiotherapy
4. Decrease in the use of radiotherapy procedures for the treatment of cancer in hospitals
5. Varian Medical Systems to Introduce RapidArc(TM) Radiotherapy Technology for Volumetric Arc Therapy at ASTRO 2007
6. Varian Medical Systems to Unveil RapidArc(TM) Volumetric Arc Therapy and Other Products Designed to Speed Delivery of Precision Radiotherapy and Brachytherapy
7. Prostate Cancer Radiotherapy Wont Affect Sexual Function
8. Normal tissue not spared in new forms of breast cancer radiotherapy
9. Varian Medical Systems Receives FDA 510(k) Clearance for RapidArc(TM) Radiotherapy Technology
10. Varian Medical Systems Announces Symposia on RapidArc Technology for Faster, More Precise Radiotherapy Treatments
11. Varian Medical Systems Announces Record Demand for New RapidArc(TM) Radiotherapy Treatment Capability
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/22/2017)... ... 22, 2017 , ... A cylindrical “pipeline” used for treating ... reach ones, according to the results of a clinical trial announced Wednesday. , ... Ricardo A. Hanel, MD, PhD, neurovascular surgeon with Baptist Health and Lyerly Neurosurgery ...
(Date:2/22/2017)... ... 22, 2017 , ... Using the power of the internet, IdrisArkette.com has managed ... a period of just 24 months, thousands of individuals interested in a medical procedure ... , “The internet is not getting quieter. In fact it’s becoming noisier by the ...
(Date:2/22/2017)... (PRWEB) , ... February 22, 2017 , ... ... of issues related to spine practices, is featuring Michigan neurosurgeon Jay Jagannathan, M.D., ... as one of a small number of neurosurgeons in Michigan performing minimally invasive ...
(Date:2/22/2017)... ... February 22, 2017 , ... Forty-five ... of those report that family members or friends have also commented about their ... hearing loss wear hearing aids. One reason, suggested by 89 percent of American ...
(Date:2/22/2017)... ... ... Social media marketing is transitioning from a singular person activity to a ... into this insight and more in its latest episode of its Brains Over Brawn ... with social media strategist and partner of the digital firm Med|Ed Digital Jessica Columbo. ...
Breaking Medicine News(10 mins):
(Date:2/22/2017)... Feb. 22, 2017 The Senior Care Pharmacy ... Senate and House of Representatives that will curtail the ... (PBMs) -- from extracting retroactive direct and indirect remuneration ... (LTC) pharmacies and the Medicare program. S. ... (R-WV) and Jon Tester (D-MT), and House ...
(Date:2/22/2017)... DUBLIN , Feb 22, 2017 Research ... Devices Market Analysis & Trends - Industry Forecast to 2025" report ... The ... of around 5.2% over the next decade to reach approximately $2.1 billion ... estimates and forecasts for all the given segments on global as well ...
(Date:2/22/2017)... 2017 Henry Schein Medical today announced ... with Rijuven, which develops innovative digital medical devices, ... practitioners. CardioSleeve is a stethoscope ... sound signals, transmits real-time data to any smartphone ... to help physicians provide diagnostic interpretation of a ...
Breaking Medicine Technology: