Navigation Links
Modified vaccine shows promise in preventing malaria
Date:9/26/2011

EAST LANSING, Mich. Continuing a global effort to prevent malaria infections, Michigan State University researchers have created a new malaria vaccine one that combines the use of a disabled cold virus with an immune system-stimulating gene that appears to increase the immune response against the parasite that causes the deadly disease.

At the same time, the group led by Andrea Amalfitano of the College of Osteopathic Medicine also discovered another immune-system stimulating agent created at MSU and which has been successful in improving immune responses in vaccines for diseases such as HIV paradoxically made for a less effective malaria vaccine.

Both of the findings will help researchers develop more effective vaccine platforms in general, and malaria vaccines specifically, hopefully leading to human clinical trials soon, Amalfitano said. The research is published in the current edition of PLoS ONE.

"Researchers across the globe are working on ways to prevent people from becoming infected with malaria," said Amalfitano of the disease that kills up to a million people each year, mainly in sub-Saharan Africa. "Some vaccines are showing promise, but they are not as effective as they need to be for any mass distribution."

Amalfitano and his research team are focusing on one such vaccine platform, spearheaded by the U.S. Army, that targets a certain gene on the malaria parasite, a protein called Circumsporozoite Protein, or CSP.

That protein is thought to play a key role in creating an immune response to the malaria parasite; past research shows people infected by malaria multiple times will begin creating an immune response to this protein, suggesting at some level it could be protective.

"What we are looking to do is improve the ability of the vaccine to induce immune responses to that protein," Amalfitano said. "We are adding genes to the vaccine to try and stimulate the immune system."

Those genetic agents, similar to chemical adjuvants, are stimulants that improve the ability of vaccines to induce beneficial immune responses in general.

In mouse models, the researchers used two such "gene-adjuvants": rEA and EAT-2, both of which aimed to illicit improved immune responses to the malaria CSP gene. Surprisingly, the rEA agent which was developed at MSU in part by the late Barnett Rosenberg did not produce the desired result and in fact seemed to worsen the animal's ability to generate an immune response to CSP.

However, the EAT-2 gene-adjuvant stimulated the immune system in a different way, and Amalfitano and his team were able to increase the ability of the immune system to respond to CSP to a level that surpassed currently available malaria vaccine systems.

"The results were surprising, but we were able to hit our goal eventually," he said. "This research will help us as we create a viable vaccine. While the way that rEA is trying to stimulate the immune system may not be the best way for malaria, we did come up with an alternative adjuvant to effectively target the parasite."

Amalfitano said the next step is to see if researchers can prevent malaria in animal models using the EAT-2 gene-adjuvant: "Then we can take the lessons learned and really go forward and do what's necessary to feel confident to begin human trials."


'/>"/>

Contact: Jason Cody
codyja@msu.edu
517-432-0924
Michigan State University
Source:Eurekalert  

Related medicine news :

1. NIH Stem Cell Guidelines Should Be Modified, UCSF Team Reports
2. Adults demonstrate modified immune response after receiving massage, Cedars-Sinai researchers show
3. New On the Menu: Genetically Modified Salmon?
4. FDA Advisers Weigh Approval of Genetically Modified Salmon
5. FDA Advisers Consider Approval of Genetically Modified Salmon
6. Consumer Activists Want Modified Salmon to Be Labeled
7. Save messengers -- modified mRNAs open up new therapeutic possibilities
8. Gene-modified stem cells help protect bone marrow from toxic side effects of chemotherapy
9. Vaccine May Prevent TB in People With HIV
10. Vaccine Not Fail-Safe in Ongoing Mumps Outbreak
11. New strategy produces promising advance in cancer vaccines
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Modified vaccine shows promise in preventing malaria
(Date:3/29/2017)... Richmond, VA (PRWEB) , ... March 29, 2017 , ... ... of its seventh North American office location in Richmond, Virginia, located at the Riverfront ... April 11, attended by Lieutenant Governor of Virginia Ralph S. Northam and Mayor of ...
(Date:3/28/2017)... ... , ... For many women, getting birth control isn’t as easy as it should be. In ... access to a health care facility or a pharmacy within 60 minutes of where they ... or for many who are faced with health or personal issues that leave them homebound. ...
(Date:3/28/2017)... ... March 28, 2017 , ... ... state legislatures and Congress to protect parental rights and civil liberties, and to ... in America. , The demonstration coincides with a press conference taking place Friday ...
(Date:3/28/2017)... , ... March 28, 2017 , ... ... software and services, is proud to announce it has joined the National Association ... representing the interests of chronically ill, disabled, and dying Americans of all ages ...
(Date:3/28/2017)... ... March 28, 2017 , ... Z-Medica, ... University of Pittsburgh Medical Center (UPMC) will acquire QuikClot® Bleeding Control Kits® (BCK) ... program, developed in association with efforts by the American College of Surgeons, U.S. ...
Breaking Medicine News(10 mins):
(Date:3/29/2017)... March 29, 2017  The Pharmaceutical Care Management Association ... PhRMA report on patient out-of-pocket spending: ... Medicaid Services (CMS), the average amount spent out-of-pocket for ... drug spending in 2016, down from 23% in 2006. ... problem, not a coverage problem. Health plans don,t have ...
(Date:3/29/2017)... , March 29, 2017  Designers of primary ... reduce solution size by 50% and extend battery life ... power management integrated circuit (PMIC) from Maxim Integrated Products, ... supports a low input voltage of just 0.7V for ... and Silver Oxide, as well as the more common ...
(Date:3/29/2017)... , March 29, 2017   Royal ... leader in health technology, and PathAI, a company ... collaborating with the aim to develop solutions that ... of cancer and other diseases. The partnership aims ... enabling this form of artificial intelligence to be ...
Breaking Medicine Technology: