Navigation Links
Modified vaccine shows promise in preventing malaria
Date:9/26/2011

EAST LANSING, Mich. Continuing a global effort to prevent malaria infections, Michigan State University researchers have created a new malaria vaccine one that combines the use of a disabled cold virus with an immune system-stimulating gene that appears to increase the immune response against the parasite that causes the deadly disease.

At the same time, the group led by Andrea Amalfitano of the College of Osteopathic Medicine also discovered another immune-system stimulating agent created at MSU and which has been successful in improving immune responses in vaccines for diseases such as HIV paradoxically made for a less effective malaria vaccine.

Both of the findings will help researchers develop more effective vaccine platforms in general, and malaria vaccines specifically, hopefully leading to human clinical trials soon, Amalfitano said. The research is published in the current edition of PLoS ONE.

"Researchers across the globe are working on ways to prevent people from becoming infected with malaria," said Amalfitano of the disease that kills up to a million people each year, mainly in sub-Saharan Africa. "Some vaccines are showing promise, but they are not as effective as they need to be for any mass distribution."

Amalfitano and his research team are focusing on one such vaccine platform, spearheaded by the U.S. Army, that targets a certain gene on the malaria parasite, a protein called Circumsporozoite Protein, or CSP.

That protein is thought to play a key role in creating an immune response to the malaria parasite; past research shows people infected by malaria multiple times will begin creating an immune response to this protein, suggesting at some level it could be protective.

"What we are looking to do is improve the ability of the vaccine to induce immune responses to that protein," Amalfitano said. "We are adding genes to the vaccine to try and stimulate the immune system."

Those genetic agents, similar to chemical adjuvants, are stimulants that improve the ability of vaccines to induce beneficial immune responses in general.

In mouse models, the researchers used two such "gene-adjuvants": rEA and EAT-2, both of which aimed to illicit improved immune responses to the malaria CSP gene. Surprisingly, the rEA agent which was developed at MSU in part by the late Barnett Rosenberg did not produce the desired result and in fact seemed to worsen the animal's ability to generate an immune response to CSP.

However, the EAT-2 gene-adjuvant stimulated the immune system in a different way, and Amalfitano and his team were able to increase the ability of the immune system to respond to CSP to a level that surpassed currently available malaria vaccine systems.

"The results were surprising, but we were able to hit our goal eventually," he said. "This research will help us as we create a viable vaccine. While the way that rEA is trying to stimulate the immune system may not be the best way for malaria, we did come up with an alternative adjuvant to effectively target the parasite."

Amalfitano said the next step is to see if researchers can prevent malaria in animal models using the EAT-2 gene-adjuvant: "Then we can take the lessons learned and really go forward and do what's necessary to feel confident to begin human trials."


'/>"/>

Contact: Jason Cody
codyja@msu.edu
517-432-0924
Michigan State University
Source:Eurekalert  

Related medicine news :

1. NIH Stem Cell Guidelines Should Be Modified, UCSF Team Reports
2. Adults demonstrate modified immune response after receiving massage, Cedars-Sinai researchers show
3. New On the Menu: Genetically Modified Salmon?
4. FDA Advisers Weigh Approval of Genetically Modified Salmon
5. FDA Advisers Consider Approval of Genetically Modified Salmon
6. Consumer Activists Want Modified Salmon to Be Labeled
7. Save messengers -- modified mRNAs open up new therapeutic possibilities
8. Gene-modified stem cells help protect bone marrow from toxic side effects of chemotherapy
9. Vaccine May Prevent TB in People With HIV
10. Vaccine Not Fail-Safe in Ongoing Mumps Outbreak
11. New strategy produces promising advance in cancer vaccines
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Modified vaccine shows promise in preventing malaria
(Date:5/4/2016)... ... May 04, 2016 , ... All-Star Insurance ... to assist the people of their local community. The agency pledges to select ... leaders. Their hope is to bring awareness to important local causes with fundraising ...
(Date:5/4/2016)... ... ... Dr. Elyson and Dr. Assili, dentist in Northridge , announce that ... a common dental procedure, is performed for many adolescents and young adults today. While ... of complications. By providing wisdom tooth removal surgery at their office, Dr. Elyson and ...
(Date:5/4/2016)... , ... May 04, 2016 , ... Francesca Loparco, Co-Founder ... her life forever with a same-day LASIK procedure at Christenbury Eye Center. ... Dr. Jonathan Christenbury performed her surgery the same day as her in-office consultation and ...
(Date:5/4/2016)... (PRWEB) , ... May 04, 2016 , ... ... all-LED multi-function small and compact tactical (6.7 inch) dual-light flashlights in models ... Vegas, model NSP-9842XL (average retail starting at $59.95) uses 2 included CR-123 batteries ...
(Date:5/4/2016)... ... May 04, 2016 , ... Warren L. Smith M.D. , There ... UTIs, have plagued people since the beginning of recorded medical history, and in ... every year. It's not just a matter of inconvenience; bladder infections cost us billions ...
Breaking Medicine News(10 mins):
(Date:5/3/2016)... -- Research and Markets has announced the ... Market Outlook 2020" report to their offering. ... technology has improved significantly in past years due to ... coming years. Many cancer drugs have been developed by ... also expected to be developed with its help. They ...
(Date:5/3/2016)... , May 3, 2016   BIOTRONIK , ... today announced Food and Drug Administration (FDA) approval ... that provides heart failure patients with access to ... also have remote monitoring with daily automatic transmission ... heart rate in response to physiological demands. ...
(Date:5/3/2016)... May 3, 2016 Pharmaceutical giant ... million to a woman who says its talc-based powder ... Gloria Ristesund $5 million in compensatory damages ... (Logo: http://photos.prnewswire.com/prnh/20160330/349511LOGO ) , This ... the company. In February, the same court awarded $72 ...
Breaking Medicine Technology: