Navigation Links
Modified-Release Prednisone May Ease Rheumatoid Arthritis
Date:1/17/2008

Pill timed to body's rhythms, helps with morning joint stiffness, researchers say

THURSDAY, Jan. 17 (HealthDay News) A modified-release form of the steroid prednisone is better than the standard, immediate-release version at reducing morning joint stiffness in people with rheumatoid arthritis, a new study finds.

German researchers at Charite University Medicine Berlin studied 288 people with active rheumatoid arthritis. Half took standard prednisone (a glucocorticoid) when they woke in the morning and half took modified-release prednisone at bedtime. The modified-release tablets dispense prednisone four hours after ingestion.

After 12 weeks of treatment, patients taking the modified-release version experienced an average of 44 minutes less morning stiffness per day than at the start of the study. That was 29.2 minutes less than those who took the standard version, the team noted.

Their report is published in the Jan. 19 issue of The Lancet.

Both versions have nearly identical total drug exposure and maximum concentration values. They have the same safety profiles.

"Our results have confirmed that the new modified-release formulation is clinically and statistically better than the conventional immediate-release preparation with regard to morning stiffness of the joints. Furthermore, the effects of the new tablet taken at night were achieved in addition to the established clinical control of the disease resulting from previous treatment with conventional immediate-release prednisone," the study authors concluded.

The study was supported by drug maker Merck, which markets the modified-release form of prednisone under the brand name Lodotra.

More information

The Arthritis Foundation has more about rheumatoid arthritis.



-- Robert Preidt



SOURCE: The Lancet, news release, Jan. 17, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. EntreMed Announces FDA Acceptance of IND Application for Panzem(R) in Rheumatoid Arthritis
2. Drug Combos Effective Against Rheumatoid Arthritis
3. Genmab and GlaxoSmithKline Initiate Ofatumumab Rheumatoid Arthritis Phase III Program
4. Combining Medications Often Best Strategy to Battle Rheumatoid Arthritis
5. Geisinger rheumatologists redesign osteoporosis, rheumatoid arthritis care
6. New Test Criteria Spots Rheumatoid Arthritis Sooner
7. Rheumatoid Arthritis Boosts Heart Disease Threat
8. Drugs Can Ease Juvenile Rheumatoid Arthritis
9. Rheumatoid Arthritis Death Rate Unchanged
10. The widening mortality gap between people with rheumatoid arthritis and the general population
11. Researchers identify genes that increase rheumatoid arthritis risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/23/2017)... ... March 23, 2017 , ... ChenMed, a privately ... completion of the strategic executive team expansion needed to further optimize growth and ... executive team,” says Christopher Chen, MD, ChenMed Chief Executive Officer. “George Wheeler ...
(Date:3/23/2017)... ... March 23, 2017 , ... Inflow IQ & Inflownomics of Raleigh, ... build on a solid foundation. As experts in dangerous situations the Inflow IQ ... coming soon. Inflownomics deliver ripe, fresh, clean & refreshing knowledge systems that enhance life. ...
(Date:3/23/2017)... ... March 23, 2017 , ... ... Force Dagger Foundation the US Special Operations Command’s Patriot Award. The award was ... Thomas thanked Task Force Dagger Foundation for its significant and enduring support to ...
(Date:3/23/2017)... ... 23, 2017 , ... “Beyond and Back”: a true-life testimony of tragedy and ... published author Bonetta Rose, a wife, mother and grandmother committed to sharing her many ... Publishing, Bonetta Rose‘s new book presents actual events in the life of her family, ...
(Date:3/23/2017)... ... March 23, 2017 , ... “The Trainer”: an ... published author, Scotty, a fiction writer with an active imagination and an enthusiasm for ... book follows the tale of Wild Bill Hart, who sat looking at the thirty-three ...
Breaking Medicine News(10 mins):
(Date:3/23/2017)... , March 23, 2017 CENTRO DE ... article 157, paragraph 4 of Law 6,404/76 and Instruction ... hereby informs its shareholders and the market in general ... its subsidiary Centro de Diagnosticos por Imagem Ltda. (" ... 100% interest in RADIOLOGISTAS ASSOCIADOS LTDA. (" Partnership " ...
(Date:3/23/2017)... 2017 Ascendis Pharma A/S (Nasdaq: ASND), a ... address significant unmet medical needs in rare diseases, today ... and webcast on Monday, April 3 during ENDO 2017, ... Orlando, Florida , to discuss new data ... Hormone, TransCon PTH and TransCon CNP). Ascendis ...
(Date:3/23/2017)... - INVICTUS MD STRATEGIES CORP. ("Invictus MD" or the "Company") ... that AB Laboratories Inc. ("AB Labs") has successfully completed ... the Access to Cannabis for Medical Purposes Regulations ("ACMPR") ... The facility, which was licensed for Cultivation ... at half capacity, with full production capacity scheduled by ...
Breaking Medicine Technology: