Navigation Links
Modified Polio Virus May Help Fight Brain Tumors, Study Suggests
Date:5/23/2013

THURSDAY, May 23 (HealthDay News) -- A modified version of the polio virus might one day help fight brain tumors, preliminary research suggests.

Scientists at Duke Cancer Institute said the investigational therapy, known as PVSRIPO, uses an engineered form of the virus that is harmless to normal cells, but attacks cancer cells. The therapy shows promise in the treatment of glioblastoma, the most common and aggressive brain tumor, they said.

"These early results are intriguing," principal investigator Dr. Annick Desjardins, an associate professor of medicine at Duke University School of Medicine, said in a news release. "Current therapies for glioblastoma are limited because they cannot cross the blood-brain barrier and often do not specifically attack the tumor. This treatment appears to overcome those problems."

The findings are scheduled for presentation at the American Society of Clinical Oncology annual meeting in Chicago, from May 31 to June 4.

Researchers at Duke said they developed the therapy to take advantage of the fact that cancer cells have receptors that attract the polio virus. The virus infects and kills the tumor cells. When infused into a tumor, the therapy also triggers the immune system to attack the infected tumor cells, the researchers said.

Of seven patients involved in the preliminary study, three have responded well to the therapy. One year after treatment, one of the three patients remains cancer-free. Another is disease-free after 11 months; a third has been cancer-free for five months. Two others are also disease-free. Only two patients in the study did not respond well to the therapy, the study authors said.

In contrast, the researchers noted that about 50 percent of glioblastoma patients have a recurrence of their disease within eight weeks of traditional treatments.

Studies presented at meetings should be considered preliminary until published in a peer-reviewed medical journal.

More information

The American Brain Tumor Association provides more information on glioblastomas.

-- Mary Elizabeth Dallas

SOURCE: Duke Medicine, news release, May 21, 2013


'/>"/>
Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Modified Burpee Bodyweight Exercise Video Released by Bodyweight Torch
2. Modified Plank Core Exercise Video Revealed By Bodyweight Torch
3. Repairing articular cartilage defects with an injectable gel engineered with gene modified BMSCs
4. Almost Nuts! Supports Whole Foods Decision on Banning Gentically Modified Salmon and Continues to Support the Movement Against Genetically Engineered Foods
5. Zane Benefits Publishes New Information on Health Care Reform and Adjusted Gross Income (AGI) vs. Modified AGI
6. Genetically modified tobacco plants produce antibodies to treat rabies
7. Almost Nuts! a Wisconsin Company Innovates Healthy Snack Foods that are Not Genetically Modified
8. Studies assess genetics, modified treatment to improve outcomes, reduce toxicity
9. Regulatory science for public health: From functional food to modified-risk tobacco products
10. Genetically modified T cell therapy shown to be safe, lasting in decade-long study of HIV patients
11. Poliovirus vaccine trial shows early promise for recurrent glioblastoma
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Modified Polio Virus May Help Fight Brain Tumors, Study Suggests
(Date:2/10/2016)... ... February 10, 2016 , ... ... S.S. Nesbitt as the latest addition to its growing list of Partner Firms. ... throughout the Southeast, from Orlando to Huntsville and in between. , Harnessing the ...
(Date:2/10/2016)... ... , ... AHRA: The Association for Medical Imaging Management announced ... serve as keynote speaker at the organization’s 2016 Spring Conference. Fox’s topic, Lead ... communicate with their own organizational staff and leadership. , “I am so ...
(Date:2/10/2016)... Florida (PRWEB) , ... February 10, 2016 , ... ... Club) announced that it has been awarded the prestigious Distinguished Emerald Club of ... award program conducted by BoardRoom magazine, one of the most respected trade publications ...
(Date:2/10/2016)... (PRWEB) , ... February 10, 2016 , ... Workrite Ergonomics ... most versatile series of monitor mounts ever. , “Our goal was to develop ... easy to install system that we have ever created.” said Darren Hulsey, Product Manager ...
(Date:2/10/2016)... ... ... A new leadership team for Mid-South Youth Camp, operated by Freed-Hardeman University, ... Monday night, Feb. 8, prior to the evening session of the university’s 80th Annual ... GO! Camp, has been named director. Gayle McDonald, currently the assistant director of MSYC, ...
Breaking Medicine News(10 mins):
(Date:2/10/2016)... SAN DIEGO , Feb. 10, 2016 ALSP, ... Hack , MD as Consultant for Medical Affairs in preparation ... Michael Pierschbacher , PhD, CEO, stated, "We are ... team. We look forward to working with an individual of ... (TBI). We look forward to drawing deeply on his broad ...
(Date:2/10/2016)... Mo. , Feb. 10, 2016 ... industry, recently identified an industry-wide trend regarding the ... that allows organizations to efficiently deliver compelling sales ... in 2011 and another in 2015, Intouch uncovered ... with tablet devices and DSAs, many are not ...
(Date:2/10/2016)... Feb. 9, 2016  Until recently, the options for ... liposuction. Thankfully, the FDA approved the non-invasive Coolsculpting treatment, ... Coolsculpting was originally approved in 2010 for the abdomen ... now the chin. With this add-on approval, the experts ... a smaller applicator, the CoolMini, to address smaller areas ...
Breaking Medicine Technology: