Navigation Links
Modified Polio Virus May Help Fight Brain Tumors, Study Suggests
Date:5/23/2013

THURSDAY, May 23 (HealthDay News) -- A modified version of the polio virus might one day help fight brain tumors, preliminary research suggests.

Scientists at Duke Cancer Institute said the investigational therapy, known as PVSRIPO, uses an engineered form of the virus that is harmless to normal cells, but attacks cancer cells. The therapy shows promise in the treatment of glioblastoma, the most common and aggressive brain tumor, they said.

"These early results are intriguing," principal investigator Dr. Annick Desjardins, an associate professor of medicine at Duke University School of Medicine, said in a news release. "Current therapies for glioblastoma are limited because they cannot cross the blood-brain barrier and often do not specifically attack the tumor. This treatment appears to overcome those problems."

The findings are scheduled for presentation at the American Society of Clinical Oncology annual meeting in Chicago, from May 31 to June 4.

Researchers at Duke said they developed the therapy to take advantage of the fact that cancer cells have receptors that attract the polio virus. The virus infects and kills the tumor cells. When infused into a tumor, the therapy also triggers the immune system to attack the infected tumor cells, the researchers said.

Of seven patients involved in the preliminary study, three have responded well to the therapy. One year after treatment, one of the three patients remains cancer-free. Another is disease-free after 11 months; a third has been cancer-free for five months. Two others are also disease-free. Only two patients in the study did not respond well to the therapy, the study authors said.

In contrast, the researchers noted that about 50 percent of glioblastoma patients have a recurrence of their disease within eight weeks of traditional treatments.

Studies presented at meetings should be considered preliminary until published in a peer-reviewed medical journal.

More information

The American Brain Tumor Association provides more information on glioblastomas.

-- Mary Elizabeth Dallas

SOURCE: Duke Medicine, news release, May 21, 2013


'/>"/>
Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Modified Burpee Bodyweight Exercise Video Released by Bodyweight Torch
2. Modified Plank Core Exercise Video Revealed By Bodyweight Torch
3. Repairing articular cartilage defects with an injectable gel engineered with gene modified BMSCs
4. Almost Nuts! Supports Whole Foods Decision on Banning Gentically Modified Salmon and Continues to Support the Movement Against Genetically Engineered Foods
5. Zane Benefits Publishes New Information on Health Care Reform and Adjusted Gross Income (AGI) vs. Modified AGI
6. Genetically modified tobacco plants produce antibodies to treat rabies
7. Almost Nuts! a Wisconsin Company Innovates Healthy Snack Foods that are Not Genetically Modified
8. Studies assess genetics, modified treatment to improve outcomes, reduce toxicity
9. Regulatory science for public health: From functional food to modified-risk tobacco products
10. Genetically modified T cell therapy shown to be safe, lasting in decade-long study of HIV patients
11. Poliovirus vaccine trial shows early promise for recurrent glioblastoma
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Modified Polio Virus May Help Fight Brain Tumors, Study Suggests
(Date:6/23/2017)... ... June 23, 2017 , ... 21 Middle East and ... has selected 21 leaders from government, business and civil society in 11 countries across ... U.S. this fall, engaging in a transformative exchange of knowledge and ideas with the ...
(Date:6/23/2017)... Jupiter, FL (PRWEB) , ... June 23, 2017 , ... ... the award winning series, which is slated to air fourth quarter 2017. American Farmer ... Christian D.A. Hansen, a Danish pharmacist, founded Chr. Hansen in Denmark in 1874 ...
(Date:6/23/2017)... ... June 23, 2017 , ... All-Star Insurance, a family managed agency that ... eastern Texas, is announcing the launch of a new charity drive to benefit women ... the United States reveal that an estimated 252, 710 new cases of invasive or ...
(Date:6/22/2017)... ... June 22, 2017 , ... Plastic Surgery Associates is proud to report that ... Each year, research and information firm, Castle Connolly, releases their list of the most ... marks the 3rd time that Dr. Canales has been recognized by Castle ...
(Date:6/22/2017)... ... 2017 , ... Despite its pervasiveness, many physicians are unfamiliar with how best ... with clinical practice. Now, however, a timely review has been published in the ... etiology of NeuP and educating preclinical scientists on its diagnosis and choice of treatment. ...
Breaking Medicine News(10 mins):
(Date:6/14/2017)... 14, 2017 The Bio Supply Management Alliance ... of Fremont and the Biomedical Manufacturing Network ... in California by providing a ... and fostering workforce development. The primary focus of this ... start-ups, as well as small and mid-sized biomedical companies. ...
(Date:6/12/2017)... SEATTLE , June 12, 2017 Kineta, Inc., ... today announced Kineta Vice President of R&D and ... at the Pandemic Preparedness for the Northwest and Beyond ... be held on June 14, 2017 from 8:30-10:30 AM PDT ... Dr. Bedard will be joined ...
(Date:6/9/2017)... 9, 2017 AirXpanders, Inc. (ASX: AXP) (AirXpanders ... design, manufacture, sale and distribution of the AeroForm® Tissue ... of its commercial roll-out in the United ... than one hundred (100) medical institutions and health systems, ... a needle-free alternative for women who choose reconstructive surgery ...
Breaking Medicine Technology: