Navigation Links
Modern targeted drug plus old malaria pill serve a 1-2 punch in advanced cancer patients
Date:4/5/2011

ORLANDO -- Researchers at the University of Pennsylvania School of Medicine may have found a way to turn an adaptive cellular response into a liability for cancer cells. When normal cells are starved for food, they chew up existing proteins and membranes to stay alive. Cancer cells have corrupted that process, called autophagy, using it to survive when they run out of nutrients and to evade death after damage from chemotherapy and other sources. When the Penn investigators treated a group of patients with several different types of advanced cancers with temsirolimus, a molecularly targeted cancer drug that blocks nutrient uptake, plus hydroxychloroquine, an anti-malarial drug that inhibits autophagy, they saw that tumors stopped growing in two-thirds of the patients.

Amaravadi's team will present the data at the American Association for Cancer Research 102nd Annual Meeting 2011 in Orlando on Tuesday, April 5. (Abstract #4500)

"The results are very encouraging -- striking, even" says senior author Ravi Amaravadi, MD, an assistant professor of Medicine at Penn's Abramson Cancer Center. "Temsirolimus by itself has little effect in this patient population. Tumors laugh at it, with response percentages of just zero to 5 percent. But by combining it with hydroxychloroquine, we found that 14 out of 21 patients had stable disease after treatment, including five out of six melanoma patients."

In addition to melanoma, patients involved in the study also had colorectal, head and neck, breast, gastro-esophageal, prostate, pancreatic, lung and adrenal cancers. Not only did patients show substantial rates of disease stabilization with the treatment combination, but the researchers report that side effects observed were relatively limited; most commonly mouth sores, weight loss, nausea, and fatigue. Two patients developed infections when the large tumors they had at the start of the trial caved in on themselves as treatment killed off the inte
'/>"/>

Contact: Holly Auer
holly.auer@uphs.upenn.edu
215-200-2313
University of Pennsylvania School of Medicine
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Study shows that modern surgery for scoliosis has good long-term outcomes
2. Learning from old bones to treat modern back pain
3. Famed neurosurgeons century-old notes reveal modern style admission of medical error
4. Sows ears and silk purses: Packing more flavor into modern pork
5. The brains journey from early Internet to modern-day fiber optics -- all in 1 lifetime
6. Action of modern drug demonstrates how 2 ancient human systems interact
7. The New 2010 Modernized Medicare Supplement Plans: Positive Changes in the Midst of Health Care Reform
8. Denver Plastic Surgeon Deploys Sophisticated Lasers in Modern Beauty, Anti-aging Treatments
9. Modern medicine conquers witchcraft
10. Bloomberg School of Public Health awarded $15 million for laboratory renovation and modernization
11. iVillage Prescribes New Health Site for the Modern Woman
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/18/2015)... The Residential Senior Care Franchises ... years. The industry, which provides residential and personal-care services ... for themselves, has boomed on account of the aging ... seniors with memory impairment. As a result, IBISWorld expects ... 4.1% to $1.9 billion over the five years to ...
(Date:4/18/2015)... Carinsurancequotesinfo.com has released a new blog post explaining ... caused by a car accident. , Car insurance ... A policy can pay for car repairs and even ... carry appropriate coverage when they are driving. ... several important riders that offer extra coverage options. One ...
(Date:4/18/2015)... Carinsurancehints.com has released a new blog post explaining how ... protection against fire damage. , Clients can now find ... vehicle is set intentionally on fire. This type of damages ... other things. , It is possible to compare the ... http://www.carinsurancehints.com/ , in just a few minutes. Clients should ...
(Date:4/18/2015)... PITTSBURGH, PA (PRWEB) April 18, 2015 ... so I decided to create a healthful juice ... an inventor from Rosedale, Md. "It increases my ... overall healthy body." , He developed Tapp's Juice ... The juice helps to prevent physical and mental ...
(Date:4/18/2015)... (PRWEB) April 18, 2015 Insuranceautoquote.info has ... online auto insurance quotes . , Clients ... a single website. The online environment provides important advantages ... vehicles. , Drivers who do not have coverage ... rates during any season, day or hour. Many agencies ...
Breaking Medicine News(10 mins):Health News:Residential Senior Care Franchises in the US Industry Market Research Report from IBISWorld Has Been Updated 2Health News:Residential Senior Care Franchises in the US Industry Market Research Report from IBISWorld Has Been Updated 3Health News:Auto Insurance Plans Can Cover Physical Injuries Caused By An Accident! 2Health News:Online Auto Insurance Quotes For Plans That Cover Fire Damages! 2Health News:Clients Can Review Car Insurance Quotes Online To Find Low Cost Offers! 2
... have poor functioning of a key heart measure may ... arteries.// ,The researchers looked specifically at how the ... the arteries, called endothelial functioning, affects the development of ... followed from childhood. Over the 21 years of the ...
... Prostate cancer is the most common cancer among men, affecting ... 220,000 new cases // of the disease are diagnosed every ... year. ,New research shows men who are diagnosed with ... a high risk of developing prostate cancer within one year. ...
... red wine each day could keep keep lung cancer away ... cancer and 187 patients requiring routine surgery between 1999 and ... early 60s. Patients were asked about their diet, smoking habits, ... each day. They were asked to specify if they drank ...
... New research shows that sleep disorders may be linked ... ADD ), // neuromuscular conditions, and psychiatric problems. ... patients with sleep apnea also had ADD. Results also ... insomnia. Further testing showed some of these patients also ...
... with uncontrolled asthma may be able to gain complete ... ,Researchers studied 3,416 patients with uncontrolled asthma. Some ... steroid for their asthma; some were on a low-dose ... steroid. Patients in all three subgroups were randomly assigned ...
... reduction surgery can successfully treat metabolic syndrome in most ... is a combination of conditions putting people at high ... is characterized by higher than normal blood sugar, high ... involved 645 patients who were treated for obesity with ...
Cached Medicine News:
(Date:4/17/2015)... RALEIGH, N.C. , April 17, 2015 /PRNewswire/ ... of the Integrated Embolic Protection™ filter platform for ... completion of a $5.6 million Series B financing ... stage venture firm with a focus on medical ... medicine. The round also included Mountain Group Partners, ...
(Date:4/17/2015)... 2015 LifeScienceIndustryResearch.com announces having ... on Global and China Lysine Industry to its ... and the deep research report in this field. ... information including definition, classification specifications, application, industry chain ... Europe , Japan ...
(Date:4/17/2015)... April 17, 2015 CVS Health Corporation (NYSE: ... on Friday, May 1, 2015, at 8:30 a.m. (EDT) ... financial results. An audio webcast of the ... Relations portion of the CVS Health website for all ... . This webcast will be archived and available on ...
Breaking Medicine Technology:Contego Medical Closes $5.6 Million in Series B Funding 2Contego Medical Closes $5.6 Million in Series B Funding 3Lysine Market International (US, Europe, Japan) Research Analysis 2Lysine Market International (US, Europe, Japan) Research Analysis 3Lysine Market International (US, Europe, Japan) Research Analysis 4Lysine Market International (US, Europe, Japan) Research Analysis 5
... 2011 ULURU Inc. (NYSE AMEX: ... of a portfolio of wound management and oral care products, ... NYSE Amex (the "Exchange"), dated December 5, 2011, indicating that ... granted the Company an extension until March 21, 2013 to ...
... CardioMEMS announced today that the U.S. Food and Drug ... the Champion Heart Failure Monitoring System, the first wireless, ... failure patients from their homes.  While the panel agreed ... of 9-1, the majority did not vote positively that ...
Cached Medicine Technology:ULURU Inc. Receives Notice From NYSE Amex Regarding Continued Listing Standards 2ULURU Inc. Receives Notice From NYSE Amex Regarding Continued Listing Standards 3FDA Advisory Panel Recommends Against Approval of Champion® Heart Failure Management System for Patients With Heart Failure 2FDA Advisory Panel Recommends Against Approval of Champion® Heart Failure Management System for Patients With Heart Failure 3
... shaped teeth set the blade on a straight accurate ... very sharp, and the cut starts true, dancing is ... minimal force due to the sharp, smooth ground, hardened ... , ,The troughs between the teeth provide an ...
Pneumatic High-speed Drill, Throttleless, 90k Rpm, Microaire Connector....
The High Speed Drill handpiece is a well-balanced, high performance drill that provides high speed for,bone sculpting, along with power for difficult osteotomies. Must be used with the 6401-000 foot ...
The High Speed Drill handpiece is a well-balanced, high performance drill that provides high speed for,bone sculpting, along with power for difficult osteotomies. Also available in a throttleless mod...
Medicine Products: