Navigation Links
Model to study age-related macular degeneration could pave way for better treatment
Date:10/9/2007

PHILADELPHIA - Researchers at the University of Pennsylvania School of Medicine have created the first animal model of age-related macular degeneration (AMD) caused by a mutation known to produce disease in people, an important first step in developing treatments. The study appears in the October issue of Human Molecular Genetics.

Age-related macular degeneration is the most common cause of vision loss in elderly people, affecting more than 10 million people in the U.S. and about 50 million world-wide. Although it is a common and debilitating condition, prevention and treatment options are limited because AMD is a difficult condition to study.

To better develop treatments for preventing the progression of AMD, we need to understand the real biochemical details of how AMD occurs, says lead author Eric A. Pierce, MD, PhD, Associate Professor of Ophthalmology at Penns K.M Kirby Center for Molecular Ophthalmology. To do that, we need a model, and now we have one.

AMD is a difficult condition to investigate because it develops late in life patients typically show symptoms of AMD after 60, and the only samples researchers could use for study were from people who died while they had the early stages of AMD, and at that point, the tissue is not useful to study the conditions progression.

AMD is caused by the development of deposits between the retinal pigment epithelium and its basement membrane, called Bruchs membrane. The material starts as basal deposits and becomes drusen, extracellular deposits of protein and lipids that accumulate and can cause blindness. In order to prevent the basal deposits from forming, researchers need to understand the mechanisms that cause them to form in the first place.

By making this particular mutant mouse, weve made a model of early macular degeneration thats caused by a mutation we know produces macular degeneration in people, says Pierce. We think its going to be a good model to study the pathogenesis of basal deposits.

Some forms of macular degeneration are inherited, and one type is thought to be caused by a mutation in the Efemp1 gene. Pierce and colleagues created a mouse model of this inherited disorder by introducing the disease-causing mutation into the Efemp1 gene of mice. The resulting Efemp1-mutant mice develop the same basal deposits as people with AMD.

Pierce and colleagues plan to use the Efemp1-mutant mice to study how basal deposits form and what they are made of. The mice can also be used to test potential treatments to prevent basal deposit formation.


'/>"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
Source:Eurekalert

Related medicine news :

1. Novel computer model for breast cancer
2. MRI, To Detect Remodeling Of Heart and Help Preserve Function
3. Down syndrome simulated in animal model after successful chromosome transplantation
4. Synthetic protein found to relieve arthritis symptoms in animal model
5. Researchers Develop Mouse Model Of Brain Tumor
6. New Model for understanding Tumor Metastasis
7. Mathematical Model Can Now Help Predict Asthma Risk
8. Model Kate Moss - Re-Birth After Humiliation
9. Heart transplanted infants better model for developing AIDS treatment
10. Mice model to study bacterial therapeutic pathway
11. Womens Self-Esteem Not Lowered By Seeing Ultra Thin Models
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/28/2017)... San Diego, CA (PRWEB) , ... March 28, 2017 , ... ... and turtlenecks from the daily wardrobe. However, for those self-conscious about a double chin, ... believe they have the ideal solution. , “For most people, a double chin ...
(Date:3/28/2017)... ... 2017 , ... Neurotechnology , a provider of high-precision ... tracking products: the new NCheck Cloud Bio Attendance cloud-based service and the updated  ... recognition to enable users to check in and out from anywhere via the ...
(Date:3/28/2017)... ... 28, 2017 , ... Columbus OH. Dr. Justin Harper, Founder of Juvly Aesthetics ... in the country to sit on the 2017 National Advisory Board for Allergan’s Facial ... Dr. Harper helped propel the clinic from a small start-up to number 78 in ...
(Date:3/28/2017)... ... March 28, 2017 , ... ... Conference in Atlantic City March 13-16, was a busy spot this year. Liz ... staff discussed strategies for preventing outbreaks among camp communities during the upcoming 2017 ...
(Date:3/28/2017)... ... March 28, 2017 , ... Nurse practitioners ... as their value increases in the healthcare workforce, according to a survey recently ... boards, career fairs, and candidate leads to healthcare employers of physicians and advanced ...
Breaking Medicine News(10 mins):
(Date:3/27/2017)... AVIV, Israel , March 27, 2017 ... on oncology and immunology, announced today that AGI-134, an immunotherapy ... announced acquisition of Agalimmune Ltd., will be featured at the ... in Washington, DC to be ... ...
(Date:3/27/2017)... March 27, 2017   Pulmatrix, Inc . (NASDAQ: PULM), ... address serious pulmonary diseases, today announced that it has added ... fibrosis and asthma to its Scientific Advisory Board . ... Richard B. Moss , MD, former chief of the ... Cystic Fibrosis Center at Stanford University, and ...
(Date:3/27/2017)... , March 27, 2017  BERG, a ... data-driven, biological research approach, today announced that ... the discovery of new data using a ... brown fat metabolism. Joslin Diabetes Center led ... Biology® platform for analysis of samples.  The ...
Breaking Medicine Technology: