Navigation Links
Model sheds new light on sports-related brain injuries
Date:4/29/2014

d in a manner that simulates the type of mild TBI that may occur in sports or other blows to the head. The researchers evaluated the mice's performance in a series of tasks designed to measure behavior. These included tests to measure spatial and learning memory, anxiety and risk-taking behavior, the presence of depression-like behavior, sleep disturbances, and the electrical activity of their brain. The mice with repetitive mild TBI did poorly in every test and this poor performance persisted over time.

"These results resemble the spectrum of neuro-behavioral problems that have been reported and observed in individuals who have sustained multiple mild TBI and those who were subsequently diagnosed with CTE, including behaviors such as poor judgment, risk taking, and depression," said Petraglia.

Petraglia and his colleagues also used the model to examine the damage that was occurring in the brains of the mice over time. The results, which will be published in a forthcoming paper, provide insight on the interaction between the brains repair mechanisms in the forms of astrocytes and microglia and the protein tau, which can have a toxic effect when triggered by mild traumatic brain injury.

"Undoubtedly further work is needed," said Petraglia. "However, this study serves as a good starting point and it is hoped that with continued investigation this novel model will allow for a controlled, mechanistic analysis of repetitive mild TBI and CTE in the future, because it is the first to encapsulate the spectrum of this human phenomenon."


'/>"/>

Contact: Mark Michaud
mark_michaud@urmc.rochester.edu
585-273-4790
University of Rochester Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. NIH scientists establish monkey model of hantavirus disease
2. Stanford scientists create circuit board modeled on the human brain
3. New prediction model to improve patient survival after paracetamol-related liver failure
4. Overcoming structural uncertainty in computer models
5. Model predicts blood glucose levels 30 minutes later
6. Diabetes drug shows promise in reducing Alzheimers disease in an experimental model
7. Multidisciplinary research team led by Tufts CTSI proposes new model for clinical trials
8. UCSF, Walgreens open new pharmacy to explore new models of patient-centered care
9. Building a better mouse model to understand pancreatic cancer
10. Toxin from brain cells triggers neuron loss in human ALS model
11. MD Anderson guides intelligent redesign of cancer care delivery model
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/5/2015)... Baltimore (PRWEB) , ... August 05, 2015 , ... ... Nivel Siete, Remote-Learner and Blackboard’s open source companies (Moodlerooms, NetSpot and Remote-Learner UK) ... to formulate common standards and guidelines that will improve and streamline the process ...
(Date:8/5/2015)... ... , ... Jvion’s CEO, Shantanu Nigam , was named Readers’ choice: 21 ... designation is given to those leaders who are enabling innovation within healthcare IT. Shantanu ... firm’s clinical predictive analytic solutions. , A spokesperson for Jvion said, “Since our inception, ...
(Date:8/5/2015)... , ... August 05, 2015 , ... ... of $5.1 Billion by 2020, signifying a firm annualized growth of 11.7% between ... experiencing a steady growth due to increasing demand of ceramic membranes technologies and ...
(Date:8/5/2015)... ... , ... The June 6 opening of Chicago’s new elevated trail, the 606, has been getting ... a group of walkers at Sedgebrook senior living community in Lincolnshire. Known as the ... preserves and twice per month to more distant places. When they read about the ...
(Date:8/5/2015)... ... ... What language does a body speak? "Body Language – from Head to Toe" ... contain the name of a body part. , The use of body part-related expressions ... and expressions, for example, “back against the wall,” “brainstorming,” “sweet tooth,” and “tongue in ...
Breaking Medicine News(10 mins):Health News:Moodle Service Providers to Simplify Moodle Plugin Development 2Health News:Moodle Service Providers to Simplify Moodle Plugin Development 3Health News:Moodle Service Providers to Simplify Moodle Plugin Development 4Health News:Jvion’s Shantanu Nigam Named One of the 21 Health IT Leaders to Know 2Health News:Ceramic Membrane Market to Grow at a CAGR of 11.7% to 2020 2Health News:Ceramic Membrane Market to Grow at a CAGR of 11.7% to 2020 3Health News:Ceramic Membrane Market to Grow at a CAGR of 11.7% to 2020 4Health News:Ceramic Membrane Market to Grow at a CAGR of 11.7% to 2020 5Health News:Sedgebrook Trailblazers Tread New Ground on Chicago’s New 606 Path 2Health News:Sedgebrook Trailblazers Tread New Ground on Chicago’s New 606 Path 3Health News:Harvard Medical Professor Dr. Per-Olof Hasselgren Pens Unique Book Using Body Part Idioms 2
... Chico,s (NYSE: CHS ) is thrilled to ... the American Heart Association,s mission to prevent cardiovascular disease ... 2009, Chico,s committed to donate $2.82 from each sale ... Heart Association (AHA) in support of its Start! Movement, ...
... Month and groups across the country and around the globe ... awareness period. The purpose of Men,s Health Month is ... early detection and treatment of disease among men and boys. ... 15-21, the week ending on Father,s Day, a special awareness ...
... been babies, adults have crooned lullabies to soothe them. But ... suckle better and reduce their pain. , If confirmed, this ... babies feed on their own faster and move them out ... clinical professor in the Faculty of Medicine & Dentistry,s Department ...
... study is the first to show that there is ... disease in the general U.S. adult population. This work ... in highly-exposed chemical workers. The study is being presented ... ), the largest international gathering of physicians and researchers ...
... Orthodox Jewish School in Northeast Philadelphia , ... Philadelphia, ... largest medical assistance managed care organization in Pennsylvania, will hold a ... a new, safe playground at Politz Hebrew Academy, an Orthodox Jewish ...
... Advance Health Care Investment OpportunitiesCHICAGO, May 29 ... private equity firm focused exclusively on the health care ... to join the firm as a partner, effective July ... Mr. Womsley, 45, will work with Water Street,s team ...
Cached Medicine News:Health News:Chico's Raises $200K for the American Heart Association 2Health News:Join Men's Health Network in Celebration of Men's Health Month 2Health News:Join Men's Health Network in Celebration of Men's Health Month 3Health News:Music may improve feeding, reduce pain in premature babies: U of A study 2Health News:Environmental pollution increases the risk of liver disease 2Health News:Groundbreaking for Safe Playground Build at Politz Hebrew Academy 2Health News:Citi Private Equity Executive Joins Water Street Healthcare Partners 2Health News:Citi Private Equity Executive Joins Water Street Healthcare Partners 3
(Date:8/4/2015)... SYDNEY and SOUTHAMPTON , ... -- Australian pharmaceutical company Pharmaxis Ltd (ASX: PXS) and UK biotechnology ... into a research collaboration to develop a selective inhibitor to ... fatal lung disease idiopathic pulmonary fibrosis (IPF). ... US. Current products are expected to produce global revenues in ...
(Date:8/4/2015)... VIEW, Calif. , Aug. 4, 2015  IRIDEX ... James H. Mackaness , who had served as chief ... since 2012, has resigned his positions with the Company, ... officer position at another company. Mr. Mackaness intends to ... Company,s second quarter earnings announcement and 10-Q filing. ...
(Date:8/4/2015)...   Regulus Therapeutics Inc . (NASDAQ: ... and development of innovative medicines targeting microRNAs, today ... ended June 30, 2015 and provided a summary ... second quarter of 2015 and recent period marked ... Paul Grint, M.D., President and CEO of Regulus. ...
Breaking Medicine Technology:Pharmaxis and Synairgen Announce Research Collaboration to Develop LOXL2 Inhibitor For Pulmonary Fibrosis 2Pharmaxis and Synairgen Announce Research Collaboration to Develop LOXL2 Inhibitor For Pulmonary Fibrosis 3IRIDEX Chief Financial Officer Resigns to Accept Another Opportunity 2Regulus Reports Second Quarter 2015 Financial Results and Recent Highlights 2Regulus Reports Second Quarter 2015 Financial Results and Recent Highlights 3Regulus Reports Second Quarter 2015 Financial Results and Recent Highlights 4Regulus Reports Second Quarter 2015 Financial Results and Recent Highlights 5Regulus Reports Second Quarter 2015 Financial Results and Recent Highlights 6Regulus Reports Second Quarter 2015 Financial Results and Recent Highlights 7Regulus Reports Second Quarter 2015 Financial Results and Recent Highlights 8Regulus Reports Second Quarter 2015 Financial Results and Recent Highlights 9Regulus Reports Second Quarter 2015 Financial Results and Recent Highlights 10
... Reaffirms Primacy and Safety of ,First Generation, Antisense, ... (Nasdaq: GNTA ) announced the presentation of ... lead anticancer,compound, can be safely administered in high ... data were presented by Dr. Anthony Tolcher, Director,of ...
... - Studies Show Improvement in Hemodynamics and Delay ... Actelion Pharmaceuticals US, Inc.,today announced positive results from ... and effective as a combination therapy,for the treatment ... suggest that Tracleer, when given in combination with ...
Cached Medicine Technology:Genasense(R) Can be Administered by Brief High-Dose IV Infusion 2Genasense(R) Can be Administered by Brief High-Dose IV Infusion 3Genasense(R) Can be Administered by Brief High-Dose IV Infusion 4Tracleer(R) Shows Clinical Benefit as Combination Therapy with Sildenafil for Pulmonary Arterial Hypertension 2Tracleer(R) Shows Clinical Benefit as Combination Therapy with Sildenafil for Pulmonary Arterial Hypertension 3
This ELISA test is used for the detection and semi-quantitation of lgG antibobies to proteinase 3(pr3) in human sera, as an aid to the diagnosis of wegener s granulomatosis....
... Enzyme-linked immunosorbent assay method for the ... to GBM in human serum. The ... used as an aid in the ... levels of anti-GBM antibodies including Goodpastures ...
The assay is an immunometric ('sandwich') EIA for the quantitative measurement of LH in human serum or plasma. LH in the sample is bound by 2 monoclonal anti-LH antibodies directed at different epito...
... (FSH) is a glycoprotein hormone secreted ... hCG, LH and TSH, the intact ... consisting of alpha- and beta-subunits. Its ... gonadotropin-releasing hormone (GnRH) from the hypothalamus. ...
Medicine Products: