Navigation Links
Model predicts blood glucose levels 30 minutes later
Date:3/25/2014

A mathematical model created by Penn State researchers can predict with more than 90 percent accuracy the blood glucose levels of individuals with type 1 diabetes up to 30 minutes in advance of imminent changes in their levels -- plenty of time to take preventative action.

"Many people with type 1 diabetes use continuous glucose monitors, which examine the fluid underneath the skin," said Peter Molenaar, Distinguished Professor of Human Development and Family Studies and of psychology. "But the glucose levels under the skin trail blood glucose levels from anywhere between 8 and 15 minutes. This is especially problematic during sleep. Patients may become hypoglycemic well before the glucose monitor alarm tells them they are hypoglycemic, and that could lead to death."

According to Molenaar, a person's blood glucose levels fluctuate in response to his or her insulin dose, meal intake, physical activity and emotional state. How great these fluctuations are depends on the individual.

"In the past decade, much progress has been made in the development of a mechanical 'artificial pancreas,' which would be a wearable or implantable automated insulin-delivery system consisting of a continuous glucose monitor, an insulin pump and a control algorithm closing the loop between glucose sensing and insulin delivery," he said. "But creating an artificial pancreas that delivers the right amount of insulin at the right times has been a challenge because it is difficult to create a control algorithm that can handle the variability among individuals. Our new model is able to capture this variability. It predicts the blood glucose levels of individuals based on insulin dose and meal intake."

The researchers created a time-varying model estimated by the extended Kalman filtering technique. This model accounts for time-varying changes in glucose kinetics due to insulin and meal intake.

The team tested the accuracy of its model using an FDA-approved UVa/Padova simulator with 30 virtual patients and five living patients with type 1 diabetes. The results appeared online this week in the Journal of Diabetes Science and Technology.

"We learned that the dynamic dependencies of blood glucose on insulin dose and meal intake vary substantially in time within each patient and between patients," said Qian Wang, professor of mechanical engineering. "The high prediction fidelity of our model over 30-minute intervals allows for the execution of optimal control of fast-acting insulin dose in real time because the initiation of insulin action has a delay of less than 30 minutes. Our approach outperforms standard approaches because all our model parameters are estimated in real time. Our model's configuration of recursive estimator and optimal controller will constitute an effective artificial pancreas."


'/>"/>

Contact: A'ndrea Elyse Messer
aem1@psu.edu
814-865-9481
Penn State
Source:Eurekalert

Related medicine news :

1. Diabetes drug shows promise in reducing Alzheimers disease in an experimental model
2. Multidisciplinary research team led by Tufts CTSI proposes new model for clinical trials
3. UCSF, Walgreens open new pharmacy to explore new models of patient-centered care
4. Building a better mouse model to understand pancreatic cancer
5. Toxin from brain cells triggers neuron loss in human ALS model
6. MD Anderson guides intelligent redesign of cancer care delivery model
7. Researchers use sensory integration model to understand unconscious priming
8. Scientists develop powerful new animal model for metastatic prostate cancer
9. New computer model may aid personalized cancer care
10. TGA Premier Junior Golf Launches School Based Activation and Business Model in Canada
11. Growth of Mice Model Industry (Oncology, Immunology, CNS) with 2018 Forecasts in a New Research Report at RnRMarketResearch.com
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/24/2017)... ... March 24, 2017 , ... The law firm of ... N.Y., is pleased to announce Westchester resident Lauren C. Enea has joined the firm ... the firm, will concentrate her practice in elder law, Medicaid planning and applications, and ...
(Date:3/24/2017)... ... 2017 , ... Viewers who like to educate themselves on current issues and ... services, and societal issues tend to appreciate and love the "Informed" series, hosted by ... running events for causes around the world. , Running for charity has ...
(Date:3/24/2017)... (PRWEB) , ... March 24, 2017 , ... ... ( http://www.hygieacare.com ) announced their partnership to prep patients for colonoscopy at the ... Endoscopy Centers in 87th Ave., Miami, FL. , The HyGIeaCare® Prep, ...
(Date:3/24/2017)... Texas (PRWEB) , ... March 24, 2017 , ... ... 2017 the year of enhancements, upgrading their training and leads programs. , In ... University. Reserved for elite sales agents, Performance Partners is designed to teach how ...
(Date:3/24/2017)... ... March 24, 2017 , ... ... Certified Medical Reiki™ Master in Frederick, MD. Judy says, “I am passionate about ... what is often a very difficult and challenging time.” , A Certified Medical ...
Breaking Medicine News(10 mins):
(Date:3/24/2017)... -- HealthMine surveys with 9,250 insured consumers fielded from February ... want help from their plans in five key areas: ... 2) help closing gaps in care, 3) better digital ... relevant, real-time guidance. Meeting these needs is essential to ... A Reason to Stay Engaged in Health ...
(Date:3/24/2017)... , March 23, 2017  Mirabilis Medical, ... advanced medical technology for non-invasive surgery, announced today ... System for treatment of uterine fibroids throughout the ... had received approval from the US Food and ... the Mirabilis System in the United States.  The ...
(Date:3/24/2017)... 2017  Provectus Biopharmaceuticals, Inc. (OTCQB: PVCT, ... oncology and dermatology biopharmaceutical company, today disclosed terms ... Sheet (the "Definitive Financing") it entered into on ... stockholders, who are referred to in the Definitive ... filed with the Securities and Exchange Commission.   ...
Breaking Medicine Technology: