Navigation Links
Model offers new understanding of cell signaling

ANN ARBOR, Mich. Looking for answers in the bright light of day, rather than the confined beam of a street light at night. Thats how University of Michigan researcher Sofia Merajver, M.D., Ph.D., describes the power of a new mathematical model that could have far-reaching impact on how scientists study cellular signaling pathways.

This has the potential to be a true paradigm shift, says Merajver, a professor in the U-M Department of Internal Medicine and co-director of the Breast Oncology Program at the U-M Comprehensive Cancer Center. She is the senior author of a study about the new model published online March 21 in Plos Computational Biology.

Around the world, researchers scrutinize the pathways inside cells where signals travel and activate or suppress thousands of cell functions. The researchers want to learn which cellular processes are key in causing disease conditions and how to target them with new drugs. Understanding the full complexity of signaling pathways and their interactions is critical in discovering effective treatments for cancer, inflammation and other conditions that affect millions of people.

The full description of the new model in the article immediately offers scientists the opportunity to improve current mathematical models with a superior tool that can take advantage of advances in computing power, says Merajver.

I would hope that it may help guide us much better than our own intuition to decide what our targets are, she says. If we can understand these pathways better, we should be able to pick more effective targets. This is the step before screening a drug. Until now, there have been very few tools to help us choose a target.

Merajvers collaborators in the study are first author Alejandra C. Ventura, Ph.D., a post-doctoral fellow in the U-M Department of Internal Medicine, Division of Hematology and Oncology and Comprehensive Cancer Center; and Jacques-A. Sepulchre, a mathematical physicist at the Institut Non Lineaire de Nice at the Universite de Nice Sophia-Antipolis in Valbonne, France.

The authors developed the model and tested it using experimental data from a well-known signaling pathway involved in many disease states, the MAPK pathway. They found that this kind of signaling pathway naturally transmits information not just in a forward direction, but also backwards. That implies new considerations if drugs are to adequately address key targets.

In addition, the study will enable scientists to construct models that take into account interactions between two pathways, or cross-talk, Merajver says.

A specialist in inflammatory breast cancer, Merajver previously has discovered oncogenes that foster metastasis. Her lab has numerous plans to put the model to work immediately.

We hope it will broaden our understanding on how to inhibit metastasis, since our lab studies this aspect of cancer; this work has many applications for normal and disease conditions, she says.


Contact: Anne Rueter
University of Michigan Health System

Related medicine news :

1. MEDai Assists Healthcare Organizations Demonstrate the Value of Predictive Modeling
2. Cato Study Finds Iran a Surprising Model for Kidney Markets
3. South African Hospital Uses Packard Childrens as Model for Nurse Retention
4. Super Model Cindy Crawford will be Honored at DKMS Linked Against Leukemia Gala on May 7th at Capitale
5. Deloittes Connected Care Model Promotes Technologically Enabled In-Home Health Care, Projects Future Health Care Savings in the Billions
6. Diabetes Ten City Challenge Collaborative Model Shows Improved Patient Health Across Key Clinical Indicators
7. Mouse model for mesothelioma reproduces human disease
8. Liko Introduces New LowBase(TM) Model of Its Popular Golvo Mobile Lift
9. UCSF researchers validate new model for breast cancer risk assessment in multiple ethnic groups
10. Jeffrey Modell Foundation and Talecris Biotherapeutics Expand Diagnostic Services for Primary Immunodeficiencies at Lucile Packard Childrens Hospital at Stanford
11. Qiao Xing Mobiles CECT Subsidiary Releases Newest Handset Model; C7000A Offers Cardiograph, 120 Days Ultra-Long Standby and 3.0 LCD Screen
Post Your Comments:
(Date:11/28/2015)... ... 2015 , ... Safe storage for contraceptive devices may not always be easy ... Jersey and the other from Bradley Beach, New Jersey, there is an easy solution ... having to replace NuvaRings more often than necessary. As such, it affords peace of ...
(Date:11/27/2015)... Los Angeles, CA (PRWEB) , ... November 27, 2015 , ... ... the conversation at the recent 2015 American Dental Association meeting in Washington D.C. revolved ... can help protect a patient’s overall health. The talk stressed the link between periodontal ...
(Date:11/27/2015)... ... 27, 2015 , ... An inventor, from Hopkinsville, Ky., thought ... at home, so he invented the patent-pending ELECTRONIC M.D. , The ELECTRONIC M.D. ... doing so, it could help to prevent potential overdose situations. As a result, ...
(Date:11/27/2015)... (PRWEB) , ... November 27, 2015 , ... MPWH, the No.1 Herpes-only dating community in ... (see Table 1-1 ). More than 3.7 billion people under the age of ... 1 (HSV-1), according to WHO's first global estimates of HSV-1 infection . , "The ...
(Date:11/27/2015)... ... November 27, 2015 , ... Keeping in ... for mental health and wellness consultation, has collaborated with a leading web-based marketplace ... knowledge gap experienced by parents and bring advice from parenting experts within their ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... --> ... att använda SyMRI för att hitta optimal ... med multipel skleros (MS) eller hjärntumörmetastaser och ... för att kunna använda SyMRI Research Edition ... kan man generera flera konstrastbilder från en ...
(Date:11/26/2015)... -- Research and Markets ( ) has ... Horizons and Growth Strategies in the Italian Therapeutic ... Forecasts, Competitive Intelligence, Emerging Opportunities" report to ... --> This new 247-page report provides ... monitoring market, including emerging tests, technologies, instrumentation, sales ...
(Date:11/25/2015)... THOUSAND OAKS, Calif. , Nov. 25, 2015 /PRNewswire/ ... of a Biologics License Application (BLA) with ... Administration (FDA) for ABP 501, a biosimilar candidate to ... the first adalimumab biosimilar application submitted to the FDA ... biosimilar pathway. Sean E. Harper , M.D., ...
Breaking Medicine Technology: