Navigation Links
Model offers new understanding of cell signaling
Date:3/24/2008

ANN ARBOR, Mich. Looking for answers in the bright light of day, rather than the confined beam of a street light at night. Thats how University of Michigan researcher Sofia Merajver, M.D., Ph.D., describes the power of a new mathematical model that could have far-reaching impact on how scientists study cellular signaling pathways.

This has the potential to be a true paradigm shift, says Merajver, a professor in the U-M Department of Internal Medicine and co-director of the Breast Oncology Program at the U-M Comprehensive Cancer Center. She is the senior author of a study about the new model published online March 21 in Plos Computational Biology.

Around the world, researchers scrutinize the pathways inside cells where signals travel and activate or suppress thousands of cell functions. The researchers want to learn which cellular processes are key in causing disease conditions and how to target them with new drugs. Understanding the full complexity of signaling pathways and their interactions is critical in discovering effective treatments for cancer, inflammation and other conditions that affect millions of people.

The full description of the new model in the article immediately offers scientists the opportunity to improve current mathematical models with a superior tool that can take advantage of advances in computing power, says Merajver.

I would hope that it may help guide us much better than our own intuition to decide what our targets are, she says. If we can understand these pathways better, we should be able to pick more effective targets. This is the step before screening a drug. Until now, there have been very few tools to help us choose a target.

Merajvers collaborators in the study are first author Alejandra C. Ventura, Ph.D., a post-doctoral fellow in the U-M Department of Internal Medicine, Division of Hematology and Oncology and Comprehensive Cancer Center; and Jacques-A. Sepulchre, a mathematical physicist at the Institut Non Lineaire de Nice at the Universite de Nice Sophia-Antipolis in Valbonne, France.

The authors developed the model and tested it using experimental data from a well-known signaling pathway involved in many disease states, the MAPK pathway. They found that this kind of signaling pathway naturally transmits information not just in a forward direction, but also backwards. That implies new considerations if drugs are to adequately address key targets.

In addition, the study will enable scientists to construct models that take into account interactions between two pathways, or cross-talk, Merajver says.

A specialist in inflammatory breast cancer, Merajver previously has discovered oncogenes that foster metastasis. Her lab has numerous plans to put the model to work immediately.

We hope it will broaden our understanding on how to inhibit metastasis, since our lab studies this aspect of cancer; this work has many applications for normal and disease conditions, she says.


'/>"/>

Contact: Anne Rueter
arueter@umich.edu
734-764-2220
University of Michigan Health System
Source:Eurekalert

Related medicine news :

1. MEDai Assists Healthcare Organizations Demonstrate the Value of Predictive Modeling
2. Cato Study Finds Iran a Surprising Model for Kidney Markets
3. South African Hospital Uses Packard Childrens as Model for Nurse Retention
4. Super Model Cindy Crawford will be Honored at DKMS Linked Against Leukemia Gala on May 7th at Capitale
5. Deloittes Connected Care Model Promotes Technologically Enabled In-Home Health Care, Projects Future Health Care Savings in the Billions
6. Diabetes Ten City Challenge Collaborative Model Shows Improved Patient Health Across Key Clinical Indicators
7. Mouse model for mesothelioma reproduces human disease
8. Liko Introduces New LowBase(TM) Model of Its Popular Golvo Mobile Lift
9. UCSF researchers validate new model for breast cancer risk assessment in multiple ethnic groups
10. Jeffrey Modell Foundation and Talecris Biotherapeutics Expand Diagnostic Services for Primary Immunodeficiencies at Lucile Packard Childrens Hospital at Stanford
11. Qiao Xing Mobiles CECT Subsidiary Releases Newest Handset Model; C7000A Offers Cardiograph, 120 Days Ultra-Long Standby and 3.0 LCD Screen
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/18/2017)... Agoura Hills, CA (PRWEB) , ... January 18, ... ... risk of dental problems ranging from gum disease to enamel erosion, and those ... from the Massachusetts Department of Public Health, many pregnant women are failing to ...
(Date:1/17/2017)... ... , ... January is National Stalking Awareness Month (NSAM), now in its fourteenth year, ... commit the crime of stalking, a very real danger to many in our community. ... stalking and other crimes. , “Stalking: know it. Name it. Stop it.”—so reads the theme ...
(Date:1/17/2017)... ... January 17, 2017 , ... Gym Source, America’s leading retailer of premium ... South Dixie Hwy in Miami, FL. , “We are elated to be opening this ... in-store concept is designed to give clients a seamless and motivating shopping experience.” , ...
(Date:1/17/2017)... Chicago, Illinois (PRWEB) , ... January 17, 2017 , ... ... Antonio Breast Cancer Symposium (SABCS) or those who desire a more intimate review and ... Antonio: Breast Cancer – Bench to Bedside—is being offered by Imedex on February 4, ...
(Date:1/17/2017)... AZ (PRWEB) , ... January 17, 2017 , ... ... and improved supplement, Healthful-Flex. , The company, owned and operated by Ed ... public at a reasonable price with the highest level of customer service. Healthful ...
Breaking Medicine News(10 mins):
(Date:1/18/2017)... 18, 2017  Tarix Orphan LLC today announced that ... Rare Pediatric Disease (RPD) designation for the company,s drug ... Bullosa (RDEB), a rare genetic skin disorder. There are ... limited to supportive care. "The RPD designation ... previously granted by the FDA in this indication," said ...
(Date:1/18/2017)... January 18, 2017 ML ... plans to publish an online presentation tomorrow, January ... sales forecast for 2017. Management reports that the ... record sales performance from its existing operations, and ... entry into the Cannabis sector through a ...
(Date:1/18/2017)...  Robust competition in the private marketplace is ... prices, according to a new study by ... the first to examine the share of prescription medicine ... managers (PBMs), health plans and other stakeholders in the ... first to show what happens when the list price ...
Breaking Medicine Technology: