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Model for new generation of blood vessels challenged
Date:6/1/2009

p>It has long been known that specialized connecting tissue cells, so-called myofibroblasts, wander in and pull the wound together. In the study being published it is shown that this wound contraction governs the in-growth of new blood vessels. Since it is a matter, at least initially, of the expansion of already existent blood vessels that have continuous blood circulation, there is a rapid in-growth of fully functional vessels, which is what we see when a wound heals.

The study not only explains a fundamental biological mechanism but also provides clues for new therapeutic goals in treating various diseases. Since myofibroblasts exist in relatively large numbers in tumors and rheumatic joints, one potential strategy to try to block the contractive capacity of these connective tissue cells. The new model can also partially explain why treatment of tumor diseases with blood-vessel inhibiting substances has not been as successful as was hoped.

Finally, the model can partially explain the mechanism behind the positive effect of "vacuum-assisted wound closure," (VAC). This is a method of treatment for hard-to-heal wounds where an air-tight bandage is applied and then the pressure is reduced in the wound with the aid of suction, which creates a continuous mechanical pull in the underlying tissue. Blood-vessel-rich wound-healing tissue is thereby generated much more rapidly, which substantially hastens healing. It is hoped that it will now be possible to understand why some wounds do not heal and also to develop new types of wound treatment.


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Contact: Pr Gerwins
Par.Gerwins@imbim.uu.se
46-073-984-8207
Uppsala University
Source:Eurekalert

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