Navigation Links
Model for new generation of blood vessels challenged
Date:6/1/2009

In-growth and new generation of blood vessels, which must take place if a wound is to heal or a tumor is to grow, have been thought to occur through a branching and further growth of a vessel against a chemical gradient of growth factors. Now a research team at Uppsala University and its University Hospital has shown that mechanical forces are considerably more important than was previously thought. The findings, published today in the journal Nature Medicine, open up a new field for developing treatments.

New generation of blood vessels takes place in normal physiological processes, such as when a wound heals, children grow, or the mucous membrane of the womb is built up to be able to receive a fertilized egg. It is also a crucial mechanism in tumor diseases, rheumatism, and certain eye disorders, for example.

How new generation and in-growth of blood vessels takes place has not been fully understood. It has been assumed that the mechanisms are the same as those that occur in embryonic development, which is probably a great over-simplification. The formation of the vascular system in the fetus takes place in a well-organized and reproducible way, which means that we all have blood vessel systems that look very much the same. On the other hand, new generation of vessels in wound healing and tumor growth, for example, occurs in a chaotic environment where it is difficult to see that there would be well-defined gradients of growth factors, and it has not been possible to find evidence of any.

"Unlike these previous models, our findings show that in wound healing, in-growth of new blood vessels takes place via mechanical forces that pull already existing blood vessels into the wound when it heals," says Pr Gerwins, who directed the study and is a physician and interventional radiologist at Uppsala University Hospital as well as a researcher with the Department of Medical Biochemistry and Microbiology at Uppsala University.

It has long been known that specialized connecting tissue cells, so-called myofibroblasts, wander in and pull the wound together. In the study being published it is shown that this wound contraction governs the in-growth of new blood vessels. Since it is a matter, at least initially, of the expansion of already existent blood vessels that have continuous blood circulation, there is a rapid in-growth of fully functional vessels, which is what we see when a wound heals.

The study not only explains a fundamental biological mechanism but also provides clues for new therapeutic goals in treating various diseases. Since myofibroblasts exist in relatively large numbers in tumors and rheumatic joints, one potential strategy to try to block the contractive capacity of these connective tissue cells. The new model can also partially explain why treatment of tumor diseases with blood-vessel inhibiting substances has not been as successful as was hoped.

Finally, the model can partially explain the mechanism behind the positive effect of "vacuum-assisted wound closure," (VAC). This is a method of treatment for hard-to-heal wounds where an air-tight bandage is applied and then the pressure is reduced in the wound with the aid of suction, which creates a continuous mechanical pull in the underlying tissue. Blood-vessel-rich wound-healing tissue is thereby generated much more rapidly, which substantially hastens healing. It is hoped that it will now be possible to understand why some wounds do not heal and also to develop new types of wound treatment.


'/>"/>

Contact: Pr Gerwins
Par.Gerwins@imbim.uu.se
46-073-984-8207
Uppsala University
Source:Eurekalert

Related medicine news :

1. Chromatin remodeling complex connected to DNA damage control
2. Health care incentive model offers collaborative approach
3. Novel 3-D cell culture model shows selective tumour uptake of nanoparticles
4. 4-Star Gen. Barry McCaffrey, Former U.S. Drug Czar, to Address National Drug Crisis, Keynote Grand Opening of New Allenwood, PA National Model Detox Center
5. A classic method for modeling skin cancer is featured in Cold Spring Harbor Protocols
6. New knock-out gene model provides molecular clues to breast cancer
7. Rain Man mice provide model for autism
8. University of Nevada School of Medicine Professor Confirms Accuracy Through Validation Study Using the CSI Health Station Model 6K
9. USC researcher identifies stem cells in tendons that regenerate tissue in animal model
10. Americas Next Top Model Steps up for Psoriasis Awareness
11. Computer models help raise the bar for sporting achievement
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/12/2017)... ... October 12, 2017 , ... Leading pediatric oncology experts at ... D.C., for the 49th Congress of the International Society of Paediatric Oncology ... the Center for Cancer and Blood Disorders at Children’s National, and Stephen ...
(Date:10/12/2017)... RAPIDS, Mich. (PRWEB) , ... October 12, 2017 ... ... Wellness, has been named one of Michigan’s 2017 Best and Brightest in Wellness® ... and Brightest in Wellness® awards program on Friday, Oct. 20 from 7:30 a.m. ...
(Date:10/12/2017)... ... 12, 2017 , ... In the United States, single-family home ... states—like New York, New Jersey, Massachusetts, Texas, Virginia, Connecticut, and California—the average is ... low property-tax rates, which contributes to the relatively lower cost of living in ...
(Date:10/12/2017)... ... 12, 2017 , ... Farm Forward joins Bon ... leading institutions in announcing the launch of the Leadership Circle , a ... are raised for food. , Founding members of the Leadership Circle also include ...
(Date:10/12/2017)... ... 12, 2017 , ... Nvision Biomedical Technologies , a ... addition of industry sales leader, Thomas (Tom) Slott, as Senior Vice President of ... sales network, direct the efforts of the surgical sales teams, manage contractual agreements, ...
Breaking Medicine News(10 mins):
(Date:10/4/2017)... -- According to the Centers for Disease Control and Prevention (CDC), influenza ... Care is helping communities across Massachusetts , ... no-cost* flu shots through the end of the month. *Some ... ... flu shot is by the end of October, according to the Centers ...
(Date:10/2/2017)... Oct. 2, 2017  Eli Lilly and Company (NYSE: ... for the third quarter of 2017 on Tuesday, October ... on that day with the investment community and media ... The conference call will begin at 9 a.m. Eastern ... a live webcast of the conference call through a ...
(Date:10/2/2017)... Denmark , Oct. 2, 2017 The Rebound ... in the struggle to reverse the tide of prescription drug ... for regulating their medicine intake and stepping down their dosage ... set to launch in December 2017; the first 100,000 people ... Learn more at http://www.rebound-solution.com/ ...
Breaking Medicine Technology: