Navigation Links
Mobile DNA elements can disrupt gene expression and cause biological variation, study shows
Date:2/23/2012

expression can be influenced very strongly by a transposon located quite a distance from the premature stop site up to many thousands of base pairs away in the genomic DNA. We also found that gene expression is influenced by whether the ERV was inherited from the father or the mother," he says.

A mouse gene containing an ERV inherited from the father often produced only an incomplete, truncated form of messenger RNA (mRNA); if the ERV came from the mother, not only the truncated transcript but also nearly normal levels of the full-length mRNA were produced from the gene.

"We believe this is an unusual, interesting example of a well-known phenomenon called DNA imprinting," Symer says. "We are now conducting experiments to understand how premature termination of gene expression can be triggered by the transposons, and also how the parent-of-origin effect occurs."

By comparing patterns of gene expression near the ERVs that were present or absent in the different strains, the researchers found about 100 genes whose expression appears to be disrupted when an ERV is present nearby.

"We observed very, very strong disruption of certain mouse genes by ERVs acting at a long genomic distance, and the resulting expression differences up to almost 50-fold changes can have major biological consequences that distinguish between the strains," Symer says.


'/>"/>

Contact: Darrell E. Ward
Darrell.Ward@osumc.edu
614-293-3737
Ohio State University Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. The Case for the iPad: Mobile Charge Capture for Physicians
2. Embedded Mobile & M2M Device revenues to Rise to Almost $19 Billion Globally by 2014, Says Juniper Research
3. Virginia House Majority Leader Morgan Griffith Sponsors Legislation Enabling Mobile Solution for Health Care SALEM, Va.
4. Red Cross Raises More Than $32 Million Via Mobile Giving Program
5. mHealth Alliance Works in Partnership with GSMA to Expand Discussion of Mobile Health at 2010 Mobile World Congress
6. Formotus Announces Support for Mobile Business Forms on Android Phones
7. WebMD Launches New Version of Free Mobile Application for Physicians
8. Can mobile phones help people EatWell?
9. Orange Healthcare Joins the mHealth Alliance to Develop Mobile Health Solutions in West Africa
10. Demand For Mobile Prostate Cancer Brachytherapy Vendor Programs Continues Into 2010
11. HealthTraveler™ is World's First Mobile App for Medical Tourism
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... The City of West Hollywood hosted a news conference ... 42nd anniversary of the Supreme Court decision Roe v. Wade, which ... since the Roe vs. Wade decision and the fight to protect ... said City of West Hollywood Councilmember Abbe Land. “We need to ...
(Date:1/22/2015)... Gabe’s Chemo Duck Program is pleased to announce the release of ... kids with cancer. The Chemo Duck App, available on iTunes for ... games to help children of all ages living with cancer adjust ... kids entertained, educated and at ease while waiting for clinic visits ...
(Date:1/22/2015)... VogueQueen is a seasoned and trusted leader who consistently ... thrilled to have it lead the wedding dress industry into ... prom dresses for the global market. , “The CEO of ... he focuses on continuing the goal of operational excellence and ...
(Date:1/22/2015)... 23, 2015 Angelweddingdress is a famous wedding ... its customers to follow it on Facebook, Twitter, and Pinterest. ... Day gift. Angelweddingdress draws a lottery every week. , Moreover, ... Feb. 28, 2015. Click Angelweddingdress homepage for more ...
(Date:1/22/2015)... AngelWeddingDress, the premier women’s dress supplier, has recently released ... website of AngelWeddingDress.com to find more details. , ... for a bridal party. AngelWeddingDress offers a variety of ... maternity wedding dresses are specially designed for 2015. , ...
Breaking Medicine News(10 mins):Health News:Chemo Duck Launches First App Ever Created for Kids with Cancer 2Health News:Chemo Duck Launches First App Ever Created for Kids with Cancer 3Health News:VogueQueen Unveils New Designs of Prom Dresses for 2015 2Health News:Angelweddingdress Invites Its Customers To Follow It On Facebook, Twitter, And Pinterest 2Health News:AngelWeddingDress Has Recently Released Its Collection Of 2015 Maternity Wedding Dresses 2
... of the mouth by trained health workers can help in ... oral cancer mortality rate. ,A research done by scientists ... to visually screen people for oral cancer in order to ... oral cancer patients. ,Oral cancer is the growth of ...
... gets bacterial infections from the bacteria Pseudomonas.// Treatment ... Research suggests that antibiotic treatment may encourage the ... infection. ,Cystic fibrosis is disease of genetic ... mucus that affects the lungs and can cause ...
... newer form of chicken pox vaccine to// effectively control the ... herpes zoster) is the condition that gets symptoms of rashes ... pain, tingling, and numbness on the area. There may be ... somewhat like chicken pox and is caused by the same ...
... College of Georgia had successfully made a protein// that will ... growth of blood vessels that may lead to obstructed vision ... applied to animals suffering from corneal injury or skin cancer ... two third of its growth. The protein is all set ...
... be at higher risk of cardiovascular disease from the// heightened ... are at higher levels, there had been more reports of ... the days the air contains more pollutant particles, the ability ... in diabetic people. ,Impaired vascular reactions in diabetic ...
... the body from the food being heated in a plastic// ... development of the fetus in womb enough to cause breast ... research, which is published in the current edition of the ... the damage. ,Bisphenol-A (BPA) is a chemical founding the ...
Cached Medicine News:
(Date:1/23/2015)... Research and Markets ( http://www.researchandmarkets.com/research/vzhr6h/video ) has announced ... Analysis, Size, Share, Growth, Trends and Forecast 2014 - 2020" ... been the topic of fascination since the era of the ... and the Soviet Russia. Earlier even a small glimpse of ...
(Date:1/23/2015)...  Northwest Biotherapeutics, Inc. (NASDAQ: NWBO )("NW Bio"), a ... and inoperable solid tumor cancers, announced today that CEO ... Annual Phacilitate Immunotherapy Forum in Washington D.C. ... place on January 26 at 10:30 a.m. EST at the ...
(Date:1/23/2015)... all-time hits leader, is the new spokesperson for the topical ... announced. "Pete,s a Hall of Famer in our ... with Myoflex," said Ducere Pharma Chief Executive Officer Chris ... across all generations. The passion and intensity that Pete brought ...
Breaking Medicine Technology:Video Telemedicine Market- Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 - 2020 2Video Telemedicine Market- Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 - 2020 3NW Bio To Present At The 7th Annual Phacilitate Immunotherapy Forum 2NW Bio To Present At The 7th Annual Phacilitate Immunotherapy Forum 3Pete Rose bets on Myoflex to relieve aches and pains 2
... MediSapiens Ltd , a Finnish bioinformatics company, has released the ... use. The data is available through a graphical tool, ... Ltd , allowing exploration of the expression activity of genes ... sequencing of the human genome, understanding which genes are expressed ...
... Systems (NYSE: VAR ) announced today that it ... following the close of regular trading on Thursday, October 27, ... available to all interested parties at 2:00 p.m. PT.  The ... will be available on the company website at: www.varian.com/investor ...
Cached Medicine Technology:Transcriptome Viewer - Comprehensive Genome-wide Map of Human Gene Expression Activity Released for Public by MediSapiens 2Varian Medical Systems Schedules Fourth Quarter FY2011 News Release and Conference Call 2
... capability to quickly deliver up to 250 ... for powerful single-pulse ablation. This type of ... coldest and cleanest CO2 surgical laser available ... with the independent adjustment of pulse energy ...
... is a new CO2 laser system with ... panel and an exclusive design for easy ... SmarXide is the leader in a ... traditional features of Dekas laser devices, like ...
... removal for all skin types, ... for leg and facial veins, ... a large spot sizes with ... treatment. An optional scanner ...
... through an ultra thin flexible 400 - 1000 ... of movement when performing surgery. The MedArt® ... of handpieces. Handpieces are supplied with standard ... Straight and angled fiber guides with different ...
Medicine Products: