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MitraClip(R) Therapy Data Demonstrate Significant Reduction in Mitral Valve Annulus Dimensions in High-Risk Patients With Functional Mitral Regurgitation
Date:9/22/2009

<0.0001 -------- ------- ------- ------- Septo-lateral mitral annular diameter (systolic) (cm) (n=33) 3.2 +/- 0.4 3.0 +/- 0.3 0.0072 ------------------------------------- ----------- ----------- ------ Septo-lateral mitral annular diameter (diastolic) (cm) (n=33) 3.8 +/- 0.3 3.6 +/- 0.3 <0.0001 ------------------------------------- ----------- ----------- ------- LV EF (percentage) (n=34) 47 +/- 11 44 +/- 11 NS ------------------------ ------- ------- ---- FSV (ml) (n=33) 51 +/- 13 55 +/- 15 0.06 -------------- ------- ------- ---- LVEDV (ml) (n = 34) 192 +/- 46 153 +/- 44 <0.0001 ------------------ -------- -------- ------- LVESV (ml) (n = 34) 103 +/- 37 87 +/- 35 0.0002 ------------------- -------- ------- ------- LVID-d (cm) (n = 34) 6.0 +/- 0.6 5.6 +/- 0.7 <0.0001 ------------------- --------- --------- ------- LVID-s (cm) (n = 34) 4.5 +/- 0.9 4.3 +/- 0.9 NS ------------------- --------- --------- ----

"We were pleased to see that in addition to a reduction in MR, patients had significant reductions in left ventricle size and mitral annual diameter we believe contributes to an improved quality of life," said Dr. Kar. "With this therapy, we have been able to expand the options available to selected patients who are at high risk for more invasive treatments, and help them to avoid the risks associated with surgery. We look forward to validating these important findings with ongoing studies."

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SOURCE Evalve, Inc.
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