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MitraClip(R) Therapy Data Demonstrate Significant Left Ventricular Reverse Remodeling in Patients With Sustained Reduction of Mitral Regurgitation
Date:9/22/2009

SAN FRANCISCO, Sept. 22 /PRNewswire/ -- Sustained reduction of mitral regurgitation following mitral valve repair with the MitraClip(R) system in patients with degenerative mitral regurgitation (DMR) or functional mitral regurgitation (FMR) led to heart function improvements, according to 12-month data from a subset of the initial registry cohort of the EVEREST (Endovascular Valve Edge-to-Edge REpair STudy) studies presented today at the Transcatheter Cardiovascular Therapeutics (TCT) Conference in San Francisco.

The data were presented today by Scott Lim, M.D., interventional cardiologist at the University of Virginia Medical Center and one of the EVEREST trial investigators. The EVEREST study was designed to evaluate the MitraClip(R) system for the treatment of MR.

This subset of the initial EVEREST registry cohort was comprised of 79 patients with moderate-to-severe (grade 3+) or severe (grade 4+) MR who had discharge MR reduction to grade 2+ or less. Of the 79 patients, 73 percent had DMR and 27 percent had FMR, and 49 continued with a MitraClip(R) device with MR less than or equal to grade 2+ at 12 months. Matched core laboratory echocardiographic data was available at baseline and 12 months. Mean MR grade reduced from 3.1+/-0.7 at baseline to 1.4+/-0.5 at 12 months. Multiple indices of left ventricle function improved significantly (LV volumes, LV mass, LV sphericity and forward stroke volume), and there was no significant change in annular dimensions.

"The 12 month data seen here in the initial cohort continue to add to the body of clinical evidence that demonstrate that the MitraClip(R) therapy may be a clinically beneficial treatment for patients suffering from degenerative or functional MR," said Dr. Lim. "The results we have seen in the EVEREST trials potentially expand the range of treatment options available to select patients, including those w
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SOURCE Evalve, Inc.
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