Navigation Links
Mitochondria play role in pathogenesis of AD and estrogen-induced neuroprotection
Date:4/5/2008

As the major source of free radicals in cells, mitochondria contribute to the high levels of oxidative stress believed to play a role in the pathogenesis of Alzheimers disease. Now, a new study from the laboratory of Dr. Roberta Brinton, University of Southern California, demonstrates that estrogen reduces this oxidative stress caused by the mitochondria while increasing the ability of the mitochondria to generate energy important since there is usually an energy deficit in the Alzheimer brain.

The study was presented April 5 at Experimental Biology 2008 in San Diego by Jia Yao, a graduate student in Dr. Brintons laboratory. The presentation is part of the scientific program of the American Association of Anatomists (AAA), and Mr. Yaos presentation is a finalist for the AAA Langman Graduate Studet Platform Presentation Award. He also received an AAA travel award.

Mitochondria, small organelles within the cells, use a process called Oxidative Phosphorylation to generate the vast majority of the adenosine triposphate (ATP) molecules that cells utilize to function properly. If the mitochondria become less efficient with age or disease, they use less up oxygen during this process. This inefficiency produces a double hit against the brain: fewer energy molecules being produced and more free radicals being released, leading to damaging oxidative stress.

Using a combination of biochemical and proteomic (protein) approaches, Dr. Brintons research team demonstrated how estrogen acts to regulate mitochondrial function in ways pivotal for protection against Alzheimers disease. These include:

  • an increase of mitochondrial efficiency, enhancing the organelles ability to generate energy-laden ATP molecules needed by the brain;

  • increased expression of key proteins required for ATP generation;

  • reduction of oxidative stress, protecting neurons from oxidative damage;

  • prevention of excess apoptosis, or programmed cell death, of neurons of the brain;

  • and protection of neurons from mitochondrial toxins, which can induce further mitochondrial dysfunction and cell death.

Dr. Brinton and her research team currently are validating the energy-production levels of mitochondria as a biomarker that could detect the presence of Alzheimers in the earliest stages, when the neurodegenerative process might be stopped or slowed or therapeutics be more effective. They believe this new information on how estrogen regulates mitochondrial function also sheds light on how to develop a new generation of effective Alzheimer therapeutics. Dr. Brinton currently is developing new, brain specific molecules that promote neurological defense against Alzheimers, using similar mechanisms as estrogen, but without estrogens negative side effects.


'/>"/>

Contact: Sylvia Wrobel
ebpress@gmail.com
770-722-1055
Federation of American Societies for Experimental Biology
Source:Eurekalert

Related medicine news :

1. Study looks at mitochondrial variation in sperm traits and sperm competitive ability
2. 454 Sequencing(TM): Science Paper Describes a Novel, Highly Efficient Method of Sequencing Ancient DNA; Sequences the Mitochondria of 10 Individual Mammoths to Prove It
3. Mitochondria send death signal to cardiac cells, study shows
4. Agent orange chemical, dioxin, attacks the mitochondria to cause cancer, says Penn research team
5. Mitochondrial bottleneck cracked
6. In silico modeling helps predict severity of mitochondrial disease
7. Single Mutation in Mitochondrial DNA Weakens Heart, Muscles
8. United Mitochondrial Disease Foundation Statement on Vaccines, Autism and Mitochondrial Disease
9. MITOCHONDRIAL DYSFUNCTION, VACCINES AND AUTISM: 1 in 50 Children Could Be at Risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2016)... ... 28, 2016 , ... USA Medical Card reminds us that May is National Stroke Awareness Month. ... fourth leading cause of death in the United States; someone has one every 40 seconds. ... in individuals under 65 years old. A stroke is when blood flow to the ...
(Date:4/28/2016)... ... April 28, 2016 , ... Point Source Audio® ... and headsets announced today that the US Patent Office has approved its patent ... structure. This innovative design creates a lightweight and modular audio headset that has ...
(Date:4/28/2016)... ... April 28, 2016 , ... Accreditation ... Community Oncology Pharmacy Association (COPA) to develop a comprehensive Specialty Pharmacy Accreditation with ... introducing an accreditation distinction. ACHC provides a wide range of pharmacy accreditation services ...
(Date:4/28/2016)... ... 28, 2016 , ... Starting today, households across the United ... Medical Prescription Assistance Program. They are customized to reflect the specific health needs ... a ready-to-use, state-themed card and, in the near future, material that highlights savings ...
(Date:4/28/2016)... (PRWEB) , ... April 28, 2016 , ... For the ... means getting smarter about an important part of overall well-being: mental health. Now, a ... do to promote healthy aging and “cognitive vitality,” which can include everything from honing ...
Breaking Medicine News(10 mins):
(Date:4/27/2016)... 2016   ... sur le trimestre, soutenu par une croissance de ... Croissance de +16% des ventes aux hôpitaux et ... Technologies (Euronext : MKEA, FR0010609263 ; OTCQX : MKEAY), inventeur de ... son chiffre d,affaires pour le premier trimestre clos ...
(Date:4/27/2016)... 2016 Elekta today announced that ... be the focal point of seven scientific presentations at ... for Radiotherapy & Oncology, taking place April 29 - ... radiotherapy system and a high-field MRI scanner with sophisticated ... patient,s anatomy in real time. The MR-linac is designed ...
(Date:4/27/2016)... , April 27, 2016   Zillion ... its digital health technology platform, which specializes in ... programs into scalable digital products, Zillion enables companies ... and empower consumers to take control of their ... live video conferencing – including one-to-one, group and ...
Breaking Medicine Technology: