Navigation Links
Mitochondria play role in pathogenesis of AD and estrogen-induced neuroprotection
Date:4/5/2008

As the major source of free radicals in cells, mitochondria contribute to the high levels of oxidative stress believed to play a role in the pathogenesis of Alzheimers disease. Now, a new study from the laboratory of Dr. Roberta Brinton, University of Southern California, demonstrates that estrogen reduces this oxidative stress caused by the mitochondria while increasing the ability of the mitochondria to generate energy important since there is usually an energy deficit in the Alzheimer brain.

The study was presented April 5 at Experimental Biology 2008 in San Diego by Jia Yao, a graduate student in Dr. Brintons laboratory. The presentation is part of the scientific program of the American Association of Anatomists (AAA), and Mr. Yaos presentation is a finalist for the AAA Langman Graduate Studet Platform Presentation Award. He also received an AAA travel award.

Mitochondria, small organelles within the cells, use a process called Oxidative Phosphorylation to generate the vast majority of the adenosine triposphate (ATP) molecules that cells utilize to function properly. If the mitochondria become less efficient with age or disease, they use less up oxygen during this process. This inefficiency produces a double hit against the brain: fewer energy molecules being produced and more free radicals being released, leading to damaging oxidative stress.

Using a combination of biochemical and proteomic (protein) approaches, Dr. Brintons research team demonstrated how estrogen acts to regulate mitochondrial function in ways pivotal for protection against Alzheimers disease. These include:

  • an increase of mitochondrial efficiency, enhancing the organelles ability to generate energy-laden ATP molecules needed by the brain;

  • increased expression of key proteins required for ATP generation;

  • reduction of oxidative stress, protecting neurons from oxidative damage;

  • prevention of excess apoptosis, or programmed cell death, of neurons of the brain;

  • and protection of neurons from mitochondrial toxins, which can induce further mitochondrial dysfunction and cell death.

Dr. Brinton and her research team currently are validating the energy-production levels of mitochondria as a biomarker that could detect the presence of Alzheimers in the earliest stages, when the neurodegenerative process might be stopped or slowed or therapeutics be more effective. They believe this new information on how estrogen regulates mitochondrial function also sheds light on how to develop a new generation of effective Alzheimer therapeutics. Dr. Brinton currently is developing new, brain specific molecules that promote neurological defense against Alzheimers, using similar mechanisms as estrogen, but without estrogens negative side effects.


'/>"/>

Contact: Sylvia Wrobel
ebpress@gmail.com
770-722-1055
Federation of American Societies for Experimental Biology
Source:Eurekalert

Related medicine news :

1. Study looks at mitochondrial variation in sperm traits and sperm competitive ability
2. 454 Sequencing(TM): Science Paper Describes a Novel, Highly Efficient Method of Sequencing Ancient DNA; Sequences the Mitochondria of 10 Individual Mammoths to Prove It
3. Mitochondria send death signal to cardiac cells, study shows
4. Agent orange chemical, dioxin, attacks the mitochondria to cause cancer, says Penn research team
5. Mitochondrial bottleneck cracked
6. In silico modeling helps predict severity of mitochondrial disease
7. Single Mutation in Mitochondrial DNA Weakens Heart, Muscles
8. United Mitochondrial Disease Foundation Statement on Vaccines, Autism and Mitochondrial Disease
9. MITOCHONDRIAL DYSFUNCTION, VACCINES AND AUTISM: 1 in 50 Children Could Be at Risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2017)... ... June 27, 2017 , ... ... the expansion of Atmosera Managed Azure Services . The trusted, transparent, and ... support of the company’s growing customer base. Atmosera’s next generation services include integrated ...
(Date:6/27/2017)... (PRWEB) , ... June 27, 2017 , ... ... treatments . Orthodontics is a dental specialty that focuses on treating alignment and ... include improved aesthetics and function. , North Hollywood dentist , Dr. ...
(Date:6/26/2017)... ... 26, 2017 , ... Dr. Martin Bastuba, MD, FACS, founder ... the Fertility Center of California, is pleased to announce the addition of two ... TESA (percutaneous testicular sperm extraction). These minimally invasive treatments are primarily used to ...
(Date:6/26/2017)... ... June 26, 2017 , ... If ... are seeing lots of red these days. According to recent estimates, 75 – ... from medical coding errors(1). Some studies point to Electronic Health Records (EHR) with ...
(Date:6/25/2017)... ... ... Republicans in the United States Senate on Thursday released their version of bill ... significantly from the American Health Care Act, which the House passed in May, so ... have to take up the Senate version as-is, if it passes. , The following ...
Breaking Medicine News(10 mins):
(Date:6/5/2017)... , June 5, 2017 Kohll,s Pharmacy & Homecare is ... the United States . The Raizer is a ... fallen person up to an almost-standing position within ... operated by one assistant and does not require ... enough that a child can operate it, and ...
(Date:5/30/2017)... , May 30, 2017 Hill-Rom Holdings, Inc. (NYSE: ... Annual Global Healthcare Conference on Tuesday, June 13, 2017, in ... Greisch , Hill-Rom,s president and chief executive officer, is scheduled ... live audio webcast can be accessed at http://ir.hill-rom.com/events.cfm . ... of the live event through September 13, 2017. ...
(Date:5/24/2017)... HAMPTON, Va. , May 24, 2017 /PRNewswire/ ... ivWatch Original Equipment Manufacturer (OEM) Board to enable ... technology with patient monitoring systems, infusion pumps and ... products, OEMs will be able to help health ... care and reduced risks related to IV therapy. ...
Breaking Medicine Technology: