Navigation Links
Missing Chromosome Improves Response to Brain Tumor Treatment

Findings show patients live average of 4 years longer than those without genetic abnormality

TUESDAY, Feb. 19 (HealthDay News) -- The lack of a chromosome actually helps people with a rare, aggressive brain tumor respond better to a new treatment, new findings show.

Gliomatosis cerebri is a type of inoperable brain tumor that is difficult to diagnosis and has an extremely variable prognosis. A study of 25 people with the condition showed that those missing chromosomes 1p and 19q did vastly better on the chemotherapy drug temozolomide, living an average of four years longer than those without the genetic abnormality.

The study is published in the Feb. 19 issue of Neurology.

"Temozolomide is now our first choice of treatment for patients with gliomatosis cerebri, especially when missing chromosomes 1p and 19q," Dr. Marc Sanson of INSERM, the French government health agency in Paris, said in a prepared statement.

Those in the study underwent genetic testing and received monthly treatments of temozolomide for up to two years. The drug had only recently been proposed as a new treatment for gliomatosis cerebri, Sanson said.

Eighty-eight percent of those missing the chromosomes responded well to the drug compared with only 25 percent of those with the chromosomes, Sanson said. Those without it also survived an average of 5.5 years compared with only 15 months for the group with the chromosomes intact. Those missing 1p and 19q also had more months without the tumor progressing, he added.

"Before now, we weren't sure which factors influenced how well a person with this type of brain tumor would respond to the treatment," Sanson said.

More information

The National Institute of Neurological Disorders and Stroke has more about brain tumors.

-- Kevin McKeever

SOURCE: American Academy of Neurology, news release, Feb. 18, 2008

Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. The National Center for Missing & Exploited Children, Wal-Mart, and Abbott Host Child Safety Events
2. Justice Department to Hold Media Event to Demonstrate New Database for Matching Unidentified Remains and Missing Persons Information
3. Some antipsychotic drugs may be missing their mark
4. The missing link between belly fat and heart disease?
5. Teens, Young Adults Missing Out on Latest Cancer Advances
6. Two Laptop Computers Missing From Lifebloods Main Office
7. Grant Supports Study of Abnormal Ring-Shaped Chromosomes
8. Optherion Licenses Worldwide Rights to Develop Age-Related Macular Degeneration Diagnostics Based on Chromosome 10 Genetic Variations
9. Herceptin helps women with multiple chromosomes containing HER2 gene, study finds
10. Chromosome Abnormalities Raise Risk for Autism
11. Study Demonstrates Marteks Algal DHA Oil Improves Blood Triglyceride Lipid Levels
Post Your Comments:
Related Image:
Missing Chromosome Improves Response to Brain Tumor Treatment
(Date:6/27/2016)... ... June 27, 2016 , ... "FCPX editors can now reveal their ... Cut Pro X," said Christina Austin - CEO of Pixel Film Studios. , ... Pro X users can now reveal the media of their split screens with ...
(Date:6/26/2016)... ... , ... Quality metrics are proliferating in cancer care, and are derived from ... of the beholder, according to experts who offered insights and commentary in the current ... For the full issue, click here . , For the American Society of ...
(Date:6/26/2016)... Lake Orion, Clarkston, Michigan (PRWEB) , ... June ... ... direction with respect to fertility once they have been diagnosed with endometriosis. These ... tolerable intercourse but they also require a comprehensive approach that can help for ...
(Date:6/25/2016)... ... June 25, 2016 , ... First Choice Emergency Room ... Dr. Sesan Ogunleye, as the Medical Director of its new Mesquite-Samuell Farm facility. ... of our new Mesquite location,” said Dr. James M. Muzzarelli, Executive Medical Director of ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... A recent ... that most people are unfamiliar with. The article goes on to state that individuals ... also many of these less common operations such as calf and cheek reduction. The ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... SAN CLEMENTE, Calif. , June 24, 2016  American ... function testing company, is now able to perform sophisticated lung assessments ... ndd Medical Technologies , Inc. Patients are no ...  Thanks to ndd,s EasyOne PRO ® , ARL patients like Jeanne ... needed testing done in the comfort of her own home. ...
(Date:6/24/2016)... , June 24, 2016   Pulmatrix, Inc ... company developing innovative inhaled drugs, announced today that it ... Russell Investments reconstituted its comprehensive set of U.S. ... "This is an important milestone for Pulmatrix," said ... increase shareholder awareness of our progress in developing drugs ...
(Date:6/23/2016)... 2016  MedSource announced today that it has ... solution of choice.  This latest decision demonstrates MedSource,s ... their clients by offering a state-of-the-art electronic data ... nowEDC as the EDC platform of choice in ... "nowEDC has long been a preferred EDC platform ...
Breaking Medicine Technology: