Navigation Links
Mislabled Supplement Spurred Prostate Cancer: Report
Date:1/18/2008

Ingredients might have led to aggressive disease in 2 men taking the product

FRIDAY, Jan. 18 (HealthDay News) -- A mislabeled over-the-counter product described as a dietary supplement appears to have contributed to the development of aggressive prostate cancer in two men, researchers report.

"There were things on the label that were not in the product, and components in the product that were not on the label," said study author Dr. Shahrokh Shariat, chief resident in urology at the University of Texas Southwestern Medical Center.

The men developed rapidly advancing prostate cancer within months of using the dietary supplement, which was advertised as something that would increase stamina and muscle mass, and strengthen the heart, Shariat said. One of the men has died and the other "is in the final stages of the disease and probably will die within months," he said.

The findings were published in the current issue of Clinical Cancer Research.

The report did not name the product or its manufacturer, at the request of the journal editors who were fearful of "possible legal implications," Shariat said. The U.S. Food and Drug Administration, notified of the findings, issued a warning letter to the manufacturer, which led to removal of the product from the market, he said.

An analysis of the product found that it contained both testosterone and estradiol, a sex hormone, he said, and laboratory tests on human prostate cancer cells found it to be a more potent stimulator of cancer cell growth than testosterone alone.

"There are a lot of such products on the market in an unregulated fashion, because androgen supplements are the fastest-growing part of the supplement business," Shariat said. "There are dangerous ones out there, and people should be aware of it."

But Andrew Shao, vice president for scientific and regulatory affairs at the Council for Responsible Nutrition, which represents the supplement industry, said the study "hasn't established any causal link here. The findings are interesting, but don't draw us any closer to any conclusion because of work done in the test tube."

Acknowledging that "any time you put something in your body you want to be cautious about it," Shao maintained that "the overwhelming majority of dietary supplements are well-made and safe, the scientific evidence supports that."

At the same time, people should be aware that "dietary supplements are not drugs and they shouldn't look forever for weight loss or performance benefit or some magic bullet when they take them," he said.

Michael McGuffin, president of the American Herbal Products Association, criticized the decision not to identify the product. "The failure to identify the exact product means that consumers who still have it in their homes are at risk," he said.

It's also a mistake to call the product a dietary supplement, McGuffin said. "I'll tell you what the FDA calls these," he said. "They call them illegal drugs. The fact that someone found one of these should not implicate every herbal product and every vitamin product as somehow being adulterated with drugs or not containing what it should. That's just not true."

Andrew Vickers, a research methodologist in the epidemiology department at Memorial Sloan-Kettering Cancer Center in New York City, called the report "very well-written and very compelling."

Both men in the report originally had low levels of prostate-specific antigen, a signal for prostate cancer "and then suddenly presented with widespread cancer within six months, which is unusual," Vickers said. "Clearly, these are very unusual cases, and there is appropriate concern with this agent."

The substance taken by the men apparently was one of a number of products being advertised as improving male sexual health, Vickers said. "They are presumably very widely used, but we really don't know what they do," he said.

When you do self-diagnosis and self-treatment, you should be cautious in general and should be in contact with your health professional, Shao said.

More information

To learn more about prostate cancer, visit the U.S. National Cancer Institute.



SOURCES: Shahrokh Shariat, M.D., chief resident, urology, University of Texas Southwestern Medical Center, Dallas; Andrew Shao, Ph.D., vice president, scientific and regulatory affairs, Council for Responsible Nutrition, Washington, D.C.; Michael McGuffin, president, American Herbal Products Association, Silver Spring, Md.; Andrew Vickers, Ph.D, research methodologist, Memorial Sloan-Kettering Cancer Center, New York City; Jan. 15, 2008, Clinical Cancer Research


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. New Blog Provides Forum for Discussions on Supplement Safety
2. Calcium Supplements Could Raise Heart Risks in Postmenopausal Women
3. TABS Group Releases Intriguing Voting Trends Based on Vitamin and Supplement Usage: Republicans More Likely to Use Supplements
4. Hormonal dietary supplements might promote prostate cancer progression
5. Testosterone supplementation for older men appears to have limited benefit
6. Recent Reports Underscore the Importance of Testing Supplements for Athletic Banned Substances
7. Research Indicates Nearly 25 Percent of Supplements Are Contaminated With Steroids, Stimulants and Banned Substances
8. More Energy & Immunity With Vitamin Supplements This Winter
9. Dallas Among the First to Offer Probiotic Supplement Align(R)
10. Cell Therapeutics, Inc. (CTI) Plans to Submit Supplemental Biologics License Application (sBLA) for ZEVALIN(R) Consolidation of First Remission in Advanced Stage Follicular Lymphoma in 2008
11. ABILIFY(R) (aripiprazole) Supplemental New Drug Application for the Treatment of Pediatric Patients with Bipolar I Disorder Accepted for Priority Review by the U.S. Food and Drug Administration
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Mislabled Supplement Spurred Prostate Cancer: Report
(Date:2/10/2016)... ... 10, 2016 , ... It’s that time of year when most people have ... Interscholastic Athletic Association of Maryland (IAAM), Hall of Fame athlete and Garrison Forest School ... aside. , That’s why one of her first decisions when her IAAM two-year presidency ...
(Date:2/9/2016)... ... February 09, 2016 , ... ... recover after a disaster, announced today the acquisition of Hawaii DKI. Hawaii DKI ... , “Investing in like-minded companies who excel at service and response helps ...
(Date:2/9/2016)... ... February 09, 2016 , ... A new study from the ... Medicare rates for a variety of medical services in Illinois as of 2015. ... 2015 Fee Schedule Rates in Illinois, are professional medical services, hospital outpatient ...
(Date:2/9/2016)... ... February 09, 2016 , ... BioPlus Specialty ... continuation of the ‘Pay It Forward’ program into 2016. BioPlus partners with several ... specialty pharmacy. , “Since our Pay It Forward program began, we are ...
(Date:2/9/2016)... (PRWEB) , ... February 10, 2016 , ... The ... the need to “level the playing field .” , As corresponding author Dr John ... we use to categorize and diagnose our chronic pain patients. ‘Chronic cancer pain’ ...
Breaking Medicine News(10 mins):
(Date:2/9/2016)... 2016 The global prefilled syringes market accounted ... expected to grow with a CAGR of 12.9% during ... segment dominated the global prefilled syringes market, with 90.1% ... --> The global market of prefilled syringes is ... geriatric population, increasing demand for vaccines, increasing prevalence of ...
(Date:2/9/2016)... The new report "Global Blood Monitoring & Cardiac Monitoring Devices Market ... group reveals that global market for blood monitoring & cardiac monitoring ... to grow to US$ 24,830.1 million by 2019 at a CAGR ... , Europe , Asia-Pacific ... and Africa . The three major factors ...
(Date:2/9/2016)... -- Increasingly, health care professionals are enhancing patient care and ... With the Vios Monitoring System from Vios Medical, health ... problems before they become serious by continuously tracking and ... the United States . --> ... --> The Vios Monitoring System connects patient-worn sensors, ...
Breaking Medicine Technology: