Navigation Links
Misidentified and contaminated cell lines lead to faulty cancer science
Date:6/21/2012

AURORA, Colo. (June 20, 2012) -AURORA, COLO (June 20, 2012) -- Modern cancer therapies start in cells researchers compare cancer samples to healthy cells to discover how cancer is genetically different, and use cell lines to test promising new drugs. However, a University of Colorado Cancer Center study published this week in the journal Gynecologic Oncology shows that due to a high rate of contamination, misidentification and redundancy in widely available cell lines, researchers may be drawing faulty conclusions.

"I've seen faculty and graduate students leave my lab in tears when we discovered the cells on the label weren't the cells they were actually experimenting on," says Christopher Korch, PhD, investigator at the CU Cancer Center and director of the center's DNA Sequencing and Analysis Service, the paper's co-first author. "When you get a cell line, you have to look that gift horse in the mouth there's up to a 40 percent chance it's a Trojan horse, not what it says it is."

For example, the cell line known as HES has been widely used as a "normal" model of endometrial cells since its development in 1989. There are literally hundreds of papers that, for example, look for differences between endometrial cancer cells and these supposedly normal HES endometrial cells. Unfortunately, HES is not, in fact, an endometrial cell line. It's another cell line known as HeLa which was first derived from cervical cancer.

"In the past, the technology to check cell lines didn't exist and so you can't really blame past researchers. But today it's cheap, it's easy and the technology is widely available. There's no excuse to experiment on cells without first discovering what you're experimenting on. We've suggested that journals start requiring verification of cell lines as a prerequisite of publishing," says Andrew Bradford, PhD, CU Cancer Center investigator and associate professor in the CU School of Medicine Department of Obstetrics a
'/>"/>

Contact: Erika Matich
erika.matich@ucdenver.edu
303-524-2780
University of Colorado Denver
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Illnesses in Colorado childrens hospital prompts discovery of contaminated alcohol pads
2. Treat Rheumatoid Arthritis Early and Aggressively: Guidelines
3. Stress contributes to cognitive declines in women with breast cancer, researcher says
4. Report outlines successes, challenges in cancer prevention efforts
5. Diabetes Groups Issue New Guidelines on Blood Sugar
6. Guidelines say diet, exercise, weight control improve odds after cancer diagnosis
7. New guidelines deliver concise messages for implementing cardiovascular prevention
8. New Guidelines Issued for Severe Lupus
9. U.S. Report Outlines Strategies to Prevent Obesity
10. U.S. Task Force Issues Blood Pressure Guidelines
11. British experts update addiction treatment guidelines
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... participation in music classes may benefit children,s language development, ... the nonprofit Harmony Project, which provides music education and ... two years, children who actively participated in the classes ... and reading, compared to those with lower levels of ... music classes occurred in the same areas of the ...
(Date:12/17/2014)... Kathleen Doheny HealthDay ... Chronic sleep loss is rampant in America, and work commitment ... is the No. 1 sleep killer," said Dr. Mathias Basner, ... the University of Pennsylvania Perelman School of Medicine. A ... older, found that work is the main activity exchanged for ...
(Date:12/15/2014)... Veretekk.com, Inc. announced today a strategic alliance ... Ocean Avenue has secured exclusive benefit to the strategic ... JM Ocean Avenue is a direct sales company ... and JM International, with partial ownership coming from JM ... , “After nearly 2 decades of servicing the industry ...
(Date:12/15/2014)... SIMpalm, a leading mobile app ... iPhone for its client, which allows users to keep ... specialized in finding the right wine. At the ... combined sensory, chemistry and wine information. All this information ... fingerprint.” Those wines that are close counterparts to one ...
(Date:12/15/2014)... HealthDay Reporter FRIDAY, Dec. 12, ... the millions of American women who have migraine: The debilitating ... is no association between migraine and breast cancer risk," said ... Harvard Medical School. "There is no positive association, so there ... effect either." About 18 percent of American women and ...
Breaking Medicine News(10 mins):Health News:Music Classes Boost Language Skills, Study Says 2Health News:Work Steals Valuable Sleep Time, Study Finds 2Health News:Work Steals Valuable Sleep Time, Study Finds 3Health News:JM Ocean Avenue secures the strategic advantages of Veretekk 2Health News:JM Ocean Avenue secures the strategic advantages of Veretekk 3Health News:JM Ocean Avenue secures the strategic advantages of Veretekk 4Health News:Use WinMatch Connect App to Keep Track of Wines You Like 2Health News: No Link Between Migraine, Breast Cancer Risk, Study Says 2
... , WEDNESDAY, Jan. 26 (HealthDay News) -- As long as ... opponents convinced that these shots do more harm than good. ... expressed more vehemently than with the standard measles-mumps-rubella (MMR) childhood ... after the retraction last year by The Lancet ...
... -- Scientists have pinpointed two gene variants that protect hepatitis ... findings are detailed in two studies that appear online and ... . The ability to identify patients with the two ... that antiviral therapy is completed and the hepatitis C virus ...
... , WEDNESDAY, Jan. 26 (HealthDay News) -- Arizona Congresswoman ... Houston Wednesday morning after her doctors upgraded her condition ... her remarkable recovery from a gunshot wound to the ... Center determined that she could be moved to nearby ...
... Vascular and Interventional Radiology the monthly, peer-reviewed flagship ... major changes for 2011all directed at highlighting the ... and its lead journal. JVIR, which has been ... medical, minimally invasive, radiological, pathological and socioeconomic issues ...
... new target for the prevention of adverse immune responses identified ... been discovered by researchers at the University of South Florida,s ... and Brain Repair. Their findings are published online in ... The CD45 molecule is a receptor on the surface of ...
... its kind surgical quality improvement program for children has the ... be targeted for quality improvement efforts to prevent complications and ... College of Surgeons National Surgical Quality Improvement Program-Pediatric (ACS NSQIP ... of the Journal of the American College of Surgeons ...
Cached Medicine News:Health News:Fear of Vaccines Has a Long, Persistent History 2Health News:Fear of Vaccines Has a Long, Persistent History 3Health News:Fear of Vaccines Has a Long, Persistent History 4Health News:Rep. Giffords Moved to Rehab Facility 2Health News:Rep. Giffords Moved to Rehab Facility 3Health News:Journal of Vascular and Interventional Radiology debuts new look, reflects global impact 2Health News:Journal of Vascular and Interventional Radiology debuts new look, reflects global impact 3Health News:Stimulating the brain's immune response may provide treatment for Alzheimer's disease 2Health News:First pediatric surgical quality program shows potential to measure children's outcomes 2
(Date:12/17/2014)... NEW YORK , Dec. 17, 2014 /PRNewswire-USNewswire/ ... resonance imaging (MRI), the MRI market is seeing ... cardiovascular and breast MRI scans account for the ... providing a higher resolution of images, which are creating ... resonance imaging (MRI) market is growing at a ...
(Date:12/17/2014)... -- , The new Dompé ... information concerning the biopharmaceutical Group,s national and international clinical research ... the recently launched institutional website that is receiving accolades from ... a new chapter in the fascinating story of Drug Discovery ... panoramic hub on the world of clinical research, ranging from ...
(Date:12/17/2014)...  IGI Laboratories, Inc. (NYSE MKT: IG; "IGI" or ... of $125 million aggregate principal amount of 3.75% Convertible ... offered and sold only to qualified institutional buyers pursuant ... as amended (the "Securities Act"). The Notes ... year, payable semiannually in arrears on June 15 and ...
Breaking Medicine Technology:Kalorama: 3T Advancements Bringing New Growth to the MRI Market 2Kalorama: 3T Advancements Bringing New Growth to the MRI Market 3Dompé Offers a New "Window" on the World of Scientific Research, with the http://www.dompetrials.com Website, Dedicated to Clinical Trials 2Dompé Offers a New "Window" on the World of Scientific Research, with the http://www.dompetrials.com Website, Dedicated to Clinical Trials 3IGI Laboratories Announces Closing of $125 Million of 3.75% Convertible Senior Notes Due 2019 2IGI Laboratories Announces Closing of $125 Million of 3.75% Convertible Senior Notes Due 2019 3IGI Laboratories Announces Closing of $125 Million of 3.75% Convertible Senior Notes Due 2019 4
... Oct. 25 In 73 years, Dr. Katherine Jeter has ... required an ostomy, she not only provided specialized care, she ... battling a personal health crisis, she recovered and focused on ... to increase the number of nurses trained to meet the ...
... the Pennsylvania State Police are reminding motorists that driving ... can be just as dangerous as driving under the ... PennDOT will work with state and municipal police departments ... increased emphasis on driving under the influence of drugs ...
Cached Medicine Technology:73-Year-Old Educator Embarks on Personal Challenge to Cycle 3,100 Miles to Raise $200,000 for WOC Nursing Scholarships 2PennDOT, State Police Caution Motorists About Dangers of Driving Under Influence of Legal Drugs 2
Unipolar Atrial "J" Lead...
The VascoTip J 9/60 PU is a unipolar tined, J-preformed permanent pacing lead. Due to advanced technology, VascoTip J 9/60 PU M is compatible to all pacemaker-cavities with the size of IS-1 (3.2 mm),...
VascoTip is a unipolar tined permanent pacing lead. Due to advanced technology, VascoTip 9/60 M is compatible to all pacemaker-cavities with the size of IS-1 (3.2 mm), 5 mm, 6 mm....
VascoTip is a unipolar tined permanent pacing lead. Due to advanced technology, VascoTip 9/60 M is compatible to all pacemaker-cavities with the size of IS-1 (3.2 mm), 5 mm, 6 mm....
Medicine Products: