Navigation Links
Misfolded neural proteins linked to autism disorders
Date:9/10/2010

An international team of scientists, led by researchers at the University of California, San Diego, has identified misfolding and other molecular anomalies in a key brain protein associated with autism spectrum disorders.

Palmer Taylor, associate vice chancellor for Health Sciences at UC San Diego and dean of the Skaggs School of Pharmacy and Pharmaceutical Sciences, and colleagues report in the September 10 issue of the Journal of Biological Chemistry that misfolding of a protein called neuroligin-3, due to gene mutations, results in trafficking deficiencies that may lead to abnormal communications between neurons.

Genetic misfolding of neuroligins is thought to prevent normal formation and function of neuronal synapses. The gene mutation has been documented in patients with autism.

"It makes sense that there's a connection," said Taylor. "The neuroligins are involved in maintaining neuronal synapses and their malfunction is likely to affect a neurodevelopmental disease."

Neuroligins are post-synaptic proteins that help glue together neurons at synapses by connecting with pre-synaptic protein partners called neurexins. They are part of a larger family of alpha-beta-hydrolase fold proteins that includes many molecules with diverse catalytic, adhesion and secretory functions.

Using live neurons in culture, the researchers found that different mutations caused different degrees of misfolding of the protein structure, which translated into trafficking deficiencies of varying severity regardless of alpha-beta-hydrolase protein type, yet resulted in distinctly different congenital disorders in the endocrine or nervous systems.

Both neuroligins and the autism mutations are relatively new to science. The former were characterized 15 years ago, the latter discovered just seven years ago. Taylor said identifying and describing the misfolded protein link advances understanding of the complex causes of certain a
'/>"/>

Contact: Scott LaFee
slafee@ucsd.edu
619-543-6163
University of California - San Diego
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Race and empathy matter on neural level
2. Neuralstem updates clinical trial progress
3. FDA approves first human neural stem cell clinical trial to treat brain tumors
4. Human neural stem cells restore motor function in mice with chronic spinal cord injury
5. Neuralstem files FDA application for first chronic spinal cord injury stem cell trial
6. Hurts so good -- neural clues to the calming effects of self-harm
7. The neural basis of the depressive self
8. SIBLING proteins may predict oral cancer
9. Proteins May Predict Spread of Colon Cancer
10. Proteins may point to alcohol use test
11. Newly identified proteins critical to FA pathway DNA repair function
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/23/2014)... of research suggesting a safe and effective role ... cancer, with fewer detrimental side effects and improved ... study will be published in final format today ... Endocrinology . , Breast cancer is the most ... States. Approximately 70% of breast cancers are diagnosed ...
(Date:7/23/2014)... of Biomedical Imaging and Bioengineering will host its second ... 2014 on the NIH campus. There will be ten ... breadth of NIBIB-funded research. , WHO: ... Rhodopsins as Optical Voltage Sensor, Quyen Nguyen, Univ. ... Nerve Imaging during Surgery, ...
(Date:7/23/2014)... 2014 The American Telemedicine Association ... twentieth annual meeting and tradeshow focused exclusively on ... attract over 5,000 attendees and more than 250 ... 3-5, 2015, in Los Angeles. , ATA’s annual ... professionals from researchers, clinicians, hospital and university administrators, ...
(Date:7/23/2014)... New York (PRWEB) July 23, 2014 ... continue to move forward in a federal multidistrict litigation ... Bernstein Liebhard LLP reports. According to an Order dated ... a hospital’s bid for payment of a $1,000 fee ... hip implant. , Among other things, the Order ...
(Date:7/23/2014)... Fragile X syndrome ( FXS ) is a ... other behaviors on the autistic spectrum, as well as ... of mental impairment and the most common cause of ... California, Riverside have published a study that ... FXS. Appearing online today (July 23) in the ...
Breaking Medicine News(10 mins):Health News:Hormones after breast cancer: Not fuel for the fire after all? 2Health News:Hormones after breast cancer: Not fuel for the fire after all? 3Health News:Hormones after breast cancer: Not fuel for the fire after all? 4Health News:Hormones after breast cancer: Not fuel for the fire after all? 5Health News:ATA Seeks Speakers to Present at the World’s Largest Telemedicine, mHealth and Telehealth Conference 2Health News:DePuy Pinnacle Hip Lawsuits Move Forward, as Federal Judge Denies Hospital Bid for $1000 Explant Fee, Bernstein Liebhard LLP Reports 2Health News:DePuy Pinnacle Hip Lawsuits Move Forward, as Federal Judge Denies Hospital Bid for $1000 Explant Fee, Bernstein Liebhard LLP Reports 3Health News:DePuy Pinnacle Hip Lawsuits Move Forward, as Federal Judge Denies Hospital Bid for $1000 Explant Fee, Bernstein Liebhard LLP Reports 4Health News:Study links enzyme to autistic behaviors 2Health News:Study links enzyme to autistic behaviors 3
... 6, 2009) The American Association of Pharmaceutical Scientists ... Ph.D., to the position of Research Fellow at the ... she will begin work this week to develop effective ... appointment comes at the end of a collaborative effort ...
... 12th annual Boston Stroke Luncheon "Making the Stroke Connection" will ... Boston from 7:30 a.m. to 12 p.m. Activities include a ... End Stroke Ambassador Training, and an awards celebration lunch from ... Janet Wu. , Milton Resident Margaret Kelly-Hayes, EdD, ...
... big chunk of change" to make Jen Ross smile. This ... raise more than $1,000 for Custom Hearts , ... heart defects or heart disease."Now that we have a big chunk ... things that we,ve wanted to do for a year and a ...
... Misperceptions About Donation Are CommonRICHMOND, Va., April 14 ... organ and tissue donors is rising, the registry still ... a report card issued by Donate Life America this ... Americans, 72 percent of people want their decision to ...
... Nu Skin Enterprises, Inc. (NYSE: NUS ) ... to the market opening on April 30, 2009. Truman ... call with the investment community later that same day beginning ... expect to hear management discuss past results as well as ...
... Association Becomes Only Major Parkinson,s Organization to Launch ... Parkinson,s DiseaseSTATEN ISLAND, N.Y., April 14 The ... Center has launched a re-designed Web site, ... onset Parkinson,s disease (PD), their family members, friends, ...
Cached Medicine News:Health News:AAPS and FDA announce appointment of research fellow 2Health News:Milton resident receives the Helen B. Spaulding Community Conscience Award 2Health News:TAN's Efforts Produce 'Chunk of Change' for Children With Heart Defects 2Health News:While the Majority of Americans Express Interest in Organ and Tissue Donation, Too Few Take Steps to Register as Donors 2Health News:While the Majority of Americans Express Interest in Organ and Tissue Donation, Too Few Take Steps to Register as Donors 3Health News:New Young Onset Parkinson's Disease Web Site Goes Live 2Health News:New Young Onset Parkinson's Disease Web Site Goes Live 3
(Date:7/23/2014)...  Cardica, Inc. (Nasdaq: CRDC ) today announced ... quarter and year ended June 30, 2014, on Thursday, August ... a conference call at 4:30 p.m. Eastern Time to discuss ... business. Conference Call Details To access the live ... Time via phone, please dial 866-953-6859 from the ...
(Date:7/23/2014)... -- Global healthcare company GSK reports Q2 ... increased price competition and supply disruptions to its Consumer ... points out that the company is very much in transition, ... confident about long-term prospects as well as the investments ... Simon Dingemans adds that the company is ...
(Date:7/23/2014)... ENGLEWOOD, Colo. , July 23 2014 ... opening of its new headquarters, manufacturing and research facility: ... Englewood, CO 80112 Direct: (720) 437-6500 ... advanced, labor efficient, pharmaceutical drug manufacturing facility will be ... to produce the first batches of Ampion TM ...
Breaking Medicine Technology:Cardica to Announce Fiscal 2014 Fourth Quarter and Full Year Financial Results on Thursday, August 7, 2014 2Ampio Pharmaceuticals announces the opening of its new headquarters, manufacturing and research facility in Englewood Colorado 2
... Pa., Feb. 16, 2011 AirPal, a medical device ... of allowance from the U.S. Patent Office for its ... for situations such as difficult airway management, laryngoscopies, diagnostic ... founded in 1982, now holds more than a dozen ...
... YORK, Feb. 16, 2011 Get content from ... The European Parliament is expected ... prevent falsified medicines from entering the legal distribution ... packages have reached patients in the last years. ...
Cached Medicine Technology:AirPal Receives Patent for Inflatable Patient Positioning Systems 2
Mounted on a sturdy, molded headband,the Classic has a fully adjustable crown,strap and cushioning that adds to,your comfort....
The Convertible lets you attach the,High Lite optic directly to your loupes....
... is a product of AlloSource, one ... human tissue processing, and Interpore Cross, ... InterGro combines AlloGro DBM with ... deliver a unique bone graft that ...
Immunoassay for the detection of Group A streptococcal antigen directly from throat swab specimens. ,Rapid, accurate diagnosis assures prompt treatment....
Medicine Products: