Navigation Links
Miriam researcher helps develop global hepatitis C recommendations for injection-drug users

(PROVIDENCE, R.I.) A Miriam Hospital researcher has joined forces with international colleagues to call for new strategies to better manage and improve assessment and treatment for hepatitis C (HCV) infection in individuals who inject drugs.

Lynn E. Taylor, M.D., an HIV specialist focusing on HIV and viral hepatitis coinfection at The Miriam Hospital, was the only American physician invited to join the expert international panel that issued these first-of-its-kind recommendations. They were published online yesterday by the journal Clinical Infectious Diseases, just ahead of World Hepatitis Day on July 28.

The recommendations are part of a supplement entitled "Prevention and Management of Hepatitis C Virus Infection Among People Who Inject Drugs: Moving the Agenda Forward," developed in collaboration with the International Network on Hepatitis Care in Substance Users.

"In well-resourced parts of the world, most hepatitis C exists among people who currently inject drugs and those who have injected drugs in the past. However, treatment access and uptake among this population remains low even though we increasingly have effective treatments for hepatitis C, which is a curable disease," said Taylor.

"Research supporting our recommendations the first international set ever released for treating hepatitis C in people who inject drugs demonstrates that treatment can be successful when barriers to care are addressed within a supportive environment," she added. "In fact, the burden of liver disease worldwide could be dramatically reduced by increasing treatment for hepatitis C infection among people who inject drugs, by preventing forward transmission."

An estimated five million people in the U.S. have chronic HCV infection, a liver disease that may result in long-term health problems, including liver scarring, liver failure and liver cancer. According to the Centers for Disease Control and Prevention, approximately 12,000 people die every year from HCV-related liver disease.

Until recently, HCV treatment guidelines excluded people who inject drugs, due to concerns about poor adherence, adverse events and re-infection. However, successful HCV treatment studies among this population have challenged this paradigm. The new international guidelines present evidence-based recommendations for treating HCV among individuals who inject drugs with appropriate evaluation and support.

Taylor is also lead author on a separate paper, appearing in the same supplement of Clinical Infectious Diseases, which focuses on the need for improved HCV care of another subset of the HCV-infected population: those who inject drugs and are also infected with HIV.

Chronic HCV infection has become a leading cause of non-AIDS related illness and death among individuals infected with HIV. Due to overlapping routes of transmission, dual infection is common: in the United States, 30 percent of HIV-infected people have chronic HCV, which is spread via contaminated blood, often through injection drug use. However, newer research suggests it may also be transmitted sexually among HIV-infected men who have sex with other men.

"HIV-infected individuals contending with injection drug use are the most likely to be affected by HCV, but the least likely to have access to treatment for HCV," said Taylor. "They should have equal and universal access to HIV/AIDS, HCV and addiction prevention, care and treatment."

She says essential but basic steps include improving prevention and screening for both infections and engaging co-infected individuals who inject drugs in HIV and HCV care early after diagnoses.

"The benefits of therapeutic advances in HCV will be limited for this group until barriers such as cost and access are overcome," she added. "Even with HCV cure rates approaching 100 percent with newer medications, effectiveness at population level will require expanding HCV therapy on large scale. These recommendations are an important step towards the goal of elimination of hepatitis C."

Taylor is also director of the HIV/Viral Hepatitis Program at The Miriam Hospital and an assistant professor of medicine at The Warren Alpert Medical School of Brown University.


Contact: Jessica Collins Grimes

Related medicine news :

1. Miriam study reveals financial benefits of a plant-based, Mediterranean diet
2. Miriam researchers urge physicians to ask younger men about erectile dysfunction symptoms
3. Researchers find potential new target to treat malignant pleural mesothelioma
4. Air Conditioning Can Dehydrate Skin and Eyes Reports Water and Health Researcher Sharon Kleyne
5. Researchers target HER1 receptor for peptide cancer vaccine, therapeutic agents
6. University Researcher, International Assistance Dog Week Founder Announce Partnership to Increase Employment for People with Disabilities Partnered with Assistance Dogs
7. Researcher develops peer-led program to help individuals with HIV adhere to treatment plans
8. University of Hawaii Cancer Center researchers report
9. Mount Sinai researchers discover mechanism behind development of autoimmune hepatitis
10. Dead gene comes to life, puts chill on inflammation, Stanford researchers find
11. Researchers identify 146 contemporary medical practices offering no net benefits
Post Your Comments:
(Date:10/13/2015)... , ... October 13, 2015 , ... ProText Kinetic Panel ... . With ProText Kinetic Panel, users can create energetic text animations in any layout ... into the Final Cut Pro X timeline and stylize the text. With intuitive on-screen ...
(Date:10/13/2015)... ... October 13, 2015 , ... In an age where the cost of ... lower per square foot than in 2009. The Williamsport Regional Medical Center (WRMC) campus ... has decreased by eight percent. , According to Facilities Management Administrative Director Dieter ...
(Date:10/13/2015)... New York, NY (PRWEB) , ... October 13, 2015 , ... ... Android®. The app helps individuals find others to train with, participate in local fitness ... the App Store and Google Play. , “As high medical costs drive us to ...
(Date:10/13/2015)... , ... October 13, 2015 , ... ... solutions, announced today their Title Sponsorship of Synergy 2015. The annual WennSoft KEY2ACT ... at Green Valley Ranch and will unite customers, partners, WennSoft team members and ...
(Date:10/13/2015)... (PRWEB) , ... October 13, 2015 , ... ... promoting the establishment of telemedicine programs in communities throughout Georgia, along with affiliate ... the collective schedule for their regional telehealth summits for Fall 2015. , ...
Breaking Medicine News(10 mins):
(Date:10/13/2015)...   Rosa & Co. LLC , the leading ... (QSP)/ PhysioPD™ , today announced that Dr. Christina ... the QSP Congress Meeting on October 20 ...  The conference focuses on the uses and benefits ... is entitled "Using Mechanistic Physiological Models in Drug Development: ...
(Date:10/13/2015)... 13, 2015 China Jo-Jo Drugstores, ... Jo-Jo "), a leading China-based retail, wholesale and online ... own online and retail pharmacies, announced preliminary half year ... online pharmacy through , growing 438% year ... 25%. China Jo-Jo,s online sales ...
(Date:10/13/2015)... N.C. , Oct. 13, 2015  Yesterday Congresswoman ... Influenza Vaccines Holly Springs manufacturing site located in ... 2014, the facility has produced Flucelvax ® (Influenza ... the potential for faster start-up and is not reliant ... CSL Limited acquired the influenza vaccines business of Novartis ...
Breaking Medicine Technology: