Navigation Links
Mini 'stress tests' could help condition heart to survive major attack
Date:1/6/2008

CINCINNATIPeople who experience brief periods of blocked blood flow may be better conditioned to survive a full-blown heart attack later, according to new research from the University of Cincinnati (UC).

In a five-year laboratory study, UC surgeon-scientist Karyn Butler, MD, found that when the heart experiences short periods of stress, either from reduced blood flow or high blood pressure, it activates a protective molecular pathwayknown as JAK-STATthat protects the heart muscle. The pathway, which is normally dormant in the heart, was originally identified in disease-fighting white blood cells as a mediator of infection and has recently been targeted for its role in heart health.

Butler says when the JAK-STAT pathway is active and functioning, it can help precondition and protect the heart from damage caused when blood flow is restored after a period of decreased flow, as occurs after a heart attack.

These mini stress tests appear to push the heart muscle into an adaptive state where it gets used to how long-term stress feels, Butler explains. This preconditioning helps the heart muscle better tolerate longer episodes of compromised blood flow.

Her team reports their findings in the January 2008 issue of the American Journal of Physiology: Heart and Circulatory Physiology.

A trauma/critical care surgeon at University Hospital in Cincinnati, Butler wanted to determine how she could help patients with heart disease from high blood pressure tolerate cardiac ischemia, which occurs when vessels become narrowed or blocked and results in a dangerous reduction of blood flow to the heart.

To study the hearts response to restored blood flow after cardiac ischemia and in the presence of hypertension, Butler developed a hypertrophied (enlarged) animal heart model to mimic the conditions of heart enlargement and congestive heart failure in humans.

The enlarged heart model was then subjected to preconditioninga series of short periods of blood flow blockageto simulate what happens in humans with serious heart disease.

Butler found that these mini stress tests activated the dormant JAK-STAT pathway, and helped protect the muscle from injury when blood flowed back into the heart.

The concept is similar to how we approach a new physical fitness regimen: incremental steps. You wouldnt try to condition yourself for a marathon by running 10 miles on your first day of training. Youd prepare yourself incrementally, explains Butler, an associate professor of surgery at UC and corresponding author of the study.

The body appears to be doing the same thing when it comes to the heart. Patients often endure short periods of reduced blood flow before the blockage causes irreversible cardiac damage, she adds. When the JAK-STAT pathway is activated, however, it appears to have a protective effect and may help the heart recover.

By revealing the underlying molecular mechanisms, Butler says, scientists may be able to develop drugs designed to selectively harness the protective benefits of the JAK-STAT pathway and help patients avoid debilitating heart injuries.

Butlers next step is to compare the effects of the JAK-STAT pathway in normal hearts with diseased hearts similar to those of patients at higher risk for heart attack.


'/>"/>

Contact: Amanda Harper
amanda.harper@uc.edu
513-558-4657
University of Cincinnati
Source:Eurekalert  

Related medicine news :

1. New research shows how chronic stress worsens neurodegenerative disease course
2. Ability to cope with stress can increase good cholesterol in older white men, study finds
3. Handling Stress Properly Increases Good Cholesterol
4. New Alzheimers findings: High stress and genetic risk factor lead to increased memory decline
5. Stressed-Out Moms Carry Babies on the Right
6. New Asthma Guidelines Stress Disease Control
7. Latest DES Analysis Stresses Importance of Physicians Well-Trained in Implantation Technique and Patient Follow-Up
8. Study identifies key player in the bodys immune response to chronic stress
9. Environmental stress probed in cardiovascular disease, diabetes
10. Parents PTSD May Boost Stress in Offspring
11. New nurses report job stress, need for better management
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Mini 'stress tests' could help condition heart to survive major attack
(Date:6/27/2017)... Beverly Hills, California (PRWEB) , ... June 27, 2017 , ... ... implants market has been projected to reach a staggering $6.81 billion by the year ... implants are rising at a faster rate than those made from titanium. Los Angeles ...
(Date:6/27/2017)... ... June 27, 2017 , ... PR News is looking for ... guidebook. This guidebook offers an excellent branding and exposure opportunity for the author ... and how-to’s that fall into the following categories:, ,     Media ...
(Date:6/27/2017)... CT (PRWEB) , ... June 27, 2017 , ... Dr. ... the recent renovation of his practice, Advanced Periodontics and Dental Implant Center of Connecticut. ... increased the administrative and waiting areas. The renovations are intended to improve patient comfort ...
(Date:6/27/2017)... ... June 27, 2017 , ... A+ Orthodontics is now offering ... focuses on treating alignment and occlusion irregularities. Treatment often includes the use of ... North Hollywood dentist , Dr. Garemani, along with Dr. Reza and the rest ...
(Date:6/26/2017)... CA (PRWEB) , ... June 26, 2017 , ... Torrance ... Smile aesthetics can be one of the most noticeable aspects of a person’s appearance. ... While not everyone is born with beautiful, balanced teeth, everyone can have the smile ...
Breaking Medicine News(10 mins):
(Date:6/7/2017)... -- Endo International plc (NASDAQ: ENDP ) ... Joseph R. Goodwin , U.S. District Court Judge for ... , entered a case management order in MDL 2325, ... Litigation (the "MDL") that includes a provision requiring plaintiffs ... on specific causation within one hundred twenty (120) days ...
(Date:6/3/2017)... -- Eli Lilly and Company (NYSE: LLY ... 3 MONARCH 2 study showed that abemaciclib, a ... with fulvestrant, significantly improved progression-free survival (PFS) compared ... hormone-receptor-positive (HR+), human epidermal growth factor receptor 2-negative ... progressed after endocrine therapy (median PFS, 16.4 vs. ...
(Date:5/30/2017)... AVIV, Israel , May 30, 2017 ... stage pharmaceutical Company specializing in the development of ... will present a company overview at three upcoming ... The 7th Annual LD Micro Invitational: ... Date:                     ...
Breaking Medicine Technology: