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Mimotopes Awarded a Major Peptide Library Supply Agreement by La Jolla Institute for their Studies Screening Dengue and Tuberculosis Pathogens
Date:12/21/2009

compared with traditional resin-based methods. LIAI is one of the world's leading immunology research centres and we are proud to be able to assist them with these important public health initiatives.”

Mycobacterium tuberculosis (MTB), the bacteria that causes Tuberculosis, is the worldwide leading cause of death from infectious disease. The increasing incidence of drug resistant strains has heightened the interest in development of effective vaccines. LIAI's Dr Alessandro Sette, the principle investigator of both the MTB and dengue studies, said, “Identification and validation of epitopes is an important step in understanding how the human immune system responds to MTB infection. We will be using Mimotopes’ peptide libraries to discover new MTB epitopes and will also be testing immune reactions from different human populations to identify those epitopes that are recognized across diverse ethnicities.” In a concurrent study to be conducted at the LIAI, dengue virus epitopes will be identified from screens of the four dengue serotypes known to cause disease. The World Health Organization reports that two fifths of the world's population are now at risk from dengue and estimates that there may be 50 million cases of dengue infection worldwide every year. Dr Sette said, “Our study will evaluate the capacity of individual dengue epitopes to stimulate the immune system using a novel experimental mouse model. Ultimately, we aim to find those epitopes that have a protective function in humans across all four dengue serotypes, as these would form the basis of an effective broad-spectrum vaccine.”

Mimotopes was the originator of peptide library technology in the 1980’s and has led the world for over 20 years in epitope discovery and mapping programs. The Company continues to develop innovative peptide library offerings and earlier this year launched a ‘small but smart’ endopeptidase profiling library bas
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