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Mimotopes Awarded Major Peptide Supply Contract by the Queensland Institute of Medical Research in the Search for an Effective Malaria Vaccine
Date:2/8/2010

e been predicted through a study of the genome sequence of Plasmodium falciparum. We are proud to play a role in assisting QIMR in the fight against one of the most widespread and deadly human diseases.”

Despite intense research efforts, malaria remains a significant public health problem worldwide. Each year, up to 3 million deaths and 300-500 million episodes of clinical illness are attributed to malaria. According to Dr Denise Doolan, Head of the Molecular Vaccinology Laboratory at QIMR, “the spread of drug-resistant Plasmodium parasites and insecticide-resistant mosquito vectors means that the development of an effective malaria vaccine is now a public health priority. However, the complexity of the Plasmodium parasite and the human host pose enormous challenges for malaria vaccine development. We will be using Mimotopes’ peptide libraries to screen up to 27,000 potential vaccine targets with the aim of developing a multi-stage, multi-component vaccine against malaria. By combining epitopes recognised by T-cells during the liver stage of the disease with epitopes recognised in the blood-stage of the disease, we hope to provide the immune system with a greater opportunity to recognise and eliminate the parasite at different stages of its life cycle.”

Large screening projects, such as the malaria vaccine work at QIMR, are uniquely suited to Mimotopes’ proprietary solid-phase peptide library platform because it allows for the production of higher purity peptides at lower unit cost compared with traditional resin-based methods. This technology has also been used by Mimotopes to produce “off-the-shelf” peptide library sets, including a protease profiling library based on fluorescence resonance energy transfer (“REPLi”) and combinatorial 2-mer and 3-mer peptide libraries used
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