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Millennium Expands IBD Franchise with Addition of New Development Candidate
Date:3/17/2008

kinetic, pharmacodynamic and safety profiles," said Nancy Simonian, M.D., Chief Medical Officer, Millennium. "These results are exciting for Millennium and IBD patients as MLN0002 is one of only a few novel product candidates being tested as alternatives to anti-TNF and other immunosuppressive therapies for the disease."

In pre-clinical models, MLN3126 has shown to be potent and selective in vitro and active as an orally administered molecule in an animal model of IBD. The molecule is expected to enter Phase I clinical trials in early 2009.

About IBD

IBD is the general name for a group of chronic disorders that cause inflammation in the gastrointestinal tract. Disorders include ulcerative Colitis and Crohn's disease.

About Crohn's Disease

Crohn's disease can affect any part of the GI tract, although it mainly presents itself in the small bowel. In Crohn's, the disease most commonly affects just the small intestine (40%), though it can often affect both the small and large intestine (colon) (30%) and in other cases just the colon (30%).

Crohn's disease affects up to 150 people per 100,000 inhabitants, and is most commonly diagnosed in the 15 to 25 year-old age groups. Recent statistics appear to indicate a rise in the number of new cases. About 15 to 20 per cent of people with Crohn's disease have a close relative with some form of IBD, suggesting a genetic predisposition in these patients.

About Millennium

Millennium Pharmaceuticals, Inc., a leading biopharmaceutical company based in Cambridge, Mass., markets VELCADE, a novel cancer product, and has a robust clinical development pipeline of product candidates. Millennium's research, development and commercialization activities are focused in two therapeutic areas: oncology and inflammation. By applying its knowledge of the human genome, understanding of disease mechanisms and industrialized drug discovery platform, Millennium is developing an exciting pipeline
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SOURCE Millennium Pharmaceuticals, Inc.
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