Navigation Links
Millennium Announces MLN1202 Significantly Reduced Marker of Systemic Inflammation and Identifies Genomic Biomarker For Responders
Date:11/6/2007

- Data confirm anti-inflammatory activity of novel CCR2 antagonist in

patients at high-risk for atherosclerosis -

CAMBRIDGE, Mass., Nov. 6 /PRNewswire-FirstCall/ -- Millennium Pharmaceuticals, Inc. (Nasdaq: MLNM) today announced that MLN1202, a novel, humanized monoclonal antibody met its primary endpoint of reducing C-reactive protein (CRP) levels in a placebo-controlled, Phase II trial of patients at high-risk for atherosclerotic cardiovascular disease. CRP level is an important, independent marker of cardiovascular morbidity and mortality. Additionally, the Company announced the identification of a genomic biomarker, which may be used for selecting patients most likely to respond to MLN1202. In this study, the genomic biomarker was identified in 53 percent of the overall patient population. These data were selected for oral presentation at the American Heart Association Scientific Session being held November 4-7, 2007 in Orlando, Florida.

(Logo: http://www.newscom.com/cgi-bin/prnh/19991220/MLNMLOGO )

"The anti-inflammatory effect of MLN1202 resulting in lower CRP, represents an exciting novel approach to reducing atherosclerosis by targeting inflammation," said Michael Davidson, M.D., Clinical Professor, Director of Preventive Cardiology, The University of Chicago Pritzker School of Medicine and Executive Medical Director, Radiant Research.

The Phase II clinical trial enrolled 108 patients at high-risk for atherosclerosis and with an elevated high-sensitivity CRP > 3.0 mg/dL. Patients were randomized to receive a single dose of either MLN1202 or placebo and were then followed for approximately
'/>"/>

SOURCE Millennium Pharmaceuticals, Inc.
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine news :

1. Bear Stearns 20th Annual Healthcare Conference to Webcast Millennium Presentation
2. Synova Healthcare to Participate in Womens Health Care in the New Millennium Conference, as Retail Distribution for the Fem-V(R) Test Kit Expands
3. Statement by Bonnie J. Campbell, Former Attorney General of Iowa and Spokesperson for Atlantic Richfield Co., Millennium Holdings, LLC, NL Industries, Inc., and The Sherwin-Williams Company on the Jury Verdict Reached Today in the Thomas (Milwaukee) Case
4. 2007 Credit Suisse Healthcare Conference to Webcast Millennium Presentation
5. HHS Announces $75 Million in Supplemental Funding to States for Pandemic Flu Preparedness
6. CRC Health Group Announces Acquisition of Bayside Marin Recovery Center, San Rafael
7. UHW Announces: Antelope Valley Hospital Caregivers and Board Vote to Ratify First Union Contract With SEIU UHW-West
8. HEI, Inc. Announces Sale of RFID Division Assets
9. Caraco Pharmaceutical Laboratories, Ltd. Announces FDA Approval to Market Generic Version of Zyloprim(R)
10. Mettler-Toledo International Inc. Announces Webcast of Presentation at Thomas Weisel Partners 2007 Healthcare Conference
11. Z Trim Announces Revocation of Gregory Halpern Severence Agreement
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/10/2014)... Thompson HealthDay Reporter THURSDAY, ... wars that break out regularly between outspoken celebrities or loudmouth ... own relationship, a new study suggests. High amounts of ... if the couple is in a long-term relationship, according to ... In turn, that friction can lead to cheating and breakups, ...
(Date:7/10/2014)... responders felt better prepared to respond to an active ... a new study in the journal Prehospital and ... specifically examine the EMS provider comfort level with respect ... yet been neutralized or working with law enforcement personnel ... High School shooting, the Virginia Tech campus shooting, the ...
(Date:7/10/2014)... amount of alcoholic beverages consumed, even for light-to-moderate ... risk of coronary heart disease, lower body mass ... new multi-center study published in The BMJ ... Medicine at the University of Pennsylvania. The latest ... that consuming light-to-moderate amounts of alcohol (0.6-0.8 fluid ...
(Date:7/10/2014)... The U.S. Department of Health and Human Services ... (UH) Case Medical Center Seidman Cancer Center totaling $4.7 ... improving care for patients with complex cancer. , ... unique model developed at UH to enhance care for ... demonstrated need for high health care utilization. ...
(Date:7/10/2014)... imaging far outweigh the risks when children receive The ... Radiation Dose. However, overuse and misuse of imaging change ... collaborative effort to ensure a national protocol is put ... Journal of Patient Safety , calls for the American ... Commission, and the Centers for Medicare & Medicaid Services ...
Breaking Medicine News(10 mins):Health News:Are You Tweeting Your Marriage Away? 2Health News:Are You Tweeting Your Marriage Away? 3Health News:Active shooter training increases comfort level of emergency responders 2Health News:New study shows drinking alcohol provides no heart health benefit 2Health News:UH Case Medical Center awarded $4.7 million grant from HHS 2Health News:UH Case Medical Center awarded $4.7 million grant from HHS 3Health News:Mayo Clinic calls for standardization of safe imaging protocols for children 2
... Analysis of a drug regimen approved by the F.D.A. ... (bevacizumab added to the standard chemotherapy regimen carboplatin and paclitaxel) ... received this regimen did not have improved survival compared to ... alone, according to a study in the April 18 issue ...
... The Prospective Surveillance Model, an innovative new model of breast ... American Cancer Society,s journal, Cancer released on April ... by women with breast cancer and offers hope for an ... through rehabilitation and exercise. APTA members Nicole ...
... (Toronto) People with an opioid addiction had the highest risk ... drugs, according to a new study by the Centre for ... on opioids, the risk of death was 5.71 times higher ... gender and race. Those with methamphetamine use disorders were next ...
... plays an integral role in physical health dates back to ... referred to as the founder of medicine, wrote "natural ... University of Missouri team has tapped into the science and ... award-winning program. Called "Taking Care of You: Body-Mind-Spirit," ...
... undergoing chemoradiation therapy (CRT) for head and neck cancer, ... short-term improvement in swallowing function; however, there were no ... and controls at nine or 12 months following treatment, ... Archives of Otolaryngology Head & Neck Surgery ...
... MONDAY, April 16 (HealthDay News) -- Tattoos and body piercings ... in western societies, but a new study in France found ... than their peers. In the study, researchers asked ... they left bars and other drinking establishments. The readings showed ...
Cached Medicine News:Health News:Study examines drug regimen for the treatment of non-small cell lung cancer among older patients 2Health News:Study examines drug regimen for the treatment of non-small cell lung cancer among older patients 3Health News:Model for breast cancer rehab featured in supplement to ACS journal, Cancer 2Health News:Opioids associated with highest risk of death 2Health News:MU receives national award for using mind-body approach to improve health 2Health News:Swallowing exercises linked with short-term improvement among patients with head and neck cancer 2Health News:Tattoos, Piercings Tied to Heavier Drinking in French Study 2
(Date:7/10/2014)... R.I. , July 10, 2014 CVS Caremark ... board of directors has approved a quarterly dividend of $0.275 ... dividend is payable on August 1, 2014, to holders of ... CVS Caremark is dedicated to helping people ... pharmacy company in the United States . ...
(Date:1/15/2014)... Jan. 15, 2014  Research and Markets ( http://www.researchandmarkets.com/research/6k27gw/dental ) ... Market - Global Industry Analysis, Size, Share, Growth, Trends ... offering. (Logo: http://photos.prnewswire.com/prnh/20130307/600769 ... used on patients in order to treat dental impairments, ...
(Date:1/15/2014)... Jan. 15, 2014 Massachusetts General Hospital (MGH), ... AMGN ) announced today that they have launched ... new therapeutic targets and develop novel therapies for ... affects millions worldwide. The MGH-Broad-Amgen collaboration brings together ...
Breaking Medicine Technology:Dental Consumables Market - Global Industry Analysis, Size, Share, Growth, Trends And Forecast, 2013 - 2018 2Dental Consumables Market - Global Industry Analysis, Size, Share, Growth, Trends And Forecast, 2013 - 2018 3Mass. General, Broad Institute and Amgen Will Work to Discover New Drugs for Inflammatory Bowel Disease 2Mass. General, Broad Institute and Amgen Will Work to Discover New Drugs for Inflammatory Bowel Disease 3Mass. General, Broad Institute and Amgen Will Work to Discover New Drugs for Inflammatory Bowel Disease 4
... Anthera Pharmaceuticals, Inc. (Nasdaq: ANTH ), a ... with abnormal auto-immune responses and inflammation, has selected the ... large scale GMP clinical and pre-commercial supplies of A-623, ... of autoimmune diseases. "Establishing a rapid and ...
... Reportlinker.com announces that a new market research report ... 2010 Pharmaceuticals Research Review ... slowdown has accentuated the fault lines already dividing ... large pharma companies, coupled with the patent expiration ...
Cached Medicine Technology:Anthera Pharmaceuticals Selects the Merck BioManufacturing Network as Manufacturing Supplier for A-623, Anthera's Investigational Novel Peptibody Agent 2Anthera Pharmaceuticals Selects the Merck BioManufacturing Network as Manufacturing Supplier for A-623, Anthera's Investigational Novel Peptibody Agent 3Anthera Pharmaceuticals Selects the Merck BioManufacturing Network as Manufacturing Supplier for A-623, Anthera's Investigational Novel Peptibody Agent 4Reportlinker Adds 2010 Pharmaceuticals Research Review 2Reportlinker Adds 2010 Pharmaceuticals Research Review 3Reportlinker Adds 2010 Pharmaceuticals Research Review 4Reportlinker Adds 2010 Pharmaceuticals Research Review 5Reportlinker Adds 2010 Pharmaceuticals Research Review 6Reportlinker Adds 2010 Pharmaceuticals Research Review 7Reportlinker Adds 2010 Pharmaceuticals Research Review 8Reportlinker Adds 2010 Pharmaceuticals Research Review 9Reportlinker Adds 2010 Pharmaceuticals Research Review 10Reportlinker Adds 2010 Pharmaceuticals Research Review 11Reportlinker Adds 2010 Pharmaceuticals Research Review 12Reportlinker Adds 2010 Pharmaceuticals Research Review 13Reportlinker Adds 2010 Pharmaceuticals Research Review 14
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: