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Milestone Scientific Expands Global Distribution Network
Date:6/3/2008

Appoints Istrodent as Exclusive Dental Distributor of the STA(TM) System in

South Africa

LIVINGSTON, N.J., June 3 /PRNewswire-FirstCall/ -- Milestone Scientific Inc. (OTC Bulletin Board: MLSS), the recognized leader in advanced injection technologies, today announced that Istrodent Pty Ltd AB, a leading South African distributor of dental products to professional dental practitioners, has been granted exclusive rights to market, distribute and sell Milestone's award-winning STA(TM) System throughout Southern Africa.

With its headquarters in Johannesburg and operations in Cape Town and Durban, Istrodent (http://www.istrodent.com) is one of the largest dental distributors and manufacturers in Southern Africa serving the needs of dentists in South Africa, Lesotho, Swaziland, Zambia, Namibia, Botswana, Mozambique, Angola, Malawi and Kenya. Recognized as the region's leading source for dental innovations and technical solutions, Istrodent represents numerous major brands and manufacturers in the global dental arena. Milestone joins other world leading suppliers that rely on Istrodent to reach the South African dental community, including KaVo-Germany, Soredex-Finland, Villa-Italy, AFP Imaging- USA, DCI-USA, SDS-USA, Tuttnauer-Israel, GC Material-Japan, OSADA Equipmen-Japan, KOMET-Germany, CATANI and MEDESY-Italy, among many others.

In addition, Istrodent has earned distinction throughout the Southern African region for building mobile dental clinics, a market it has dominated since 1994. Through Istrodent's successful collaborations with Colgate/Transnet on the Phelopepa Healthcare Train and with the South African Government, there are at least 100 mobile dental clinics currently in operation within the South African borders.

According to Joe Martin, Chief Executive Officer of Milestone, "Working with Istrodent, Milestone achieved notable market penetration of the South African dental market for The Wand(R). In fact, Istrodent has historically proven to be one of our strongest marketing allies outside of the United States. Consequently, we are pleased that we have the opportunity to once again leverage Istrodent's market leadership to introduce the STA System."

The state-of-the-art STA System is Milestone's latest achievement in computer-controlled local anesthesia delivery (CCLAD) that makes the injection process more comfortable for both dentists and patients. Marketed for use by dental practitioners to painlessly administer all dental injections, the STA System is uniquely capable of administering "Single Tooth Anesthesia" into the Peridontal Intraligamentary (PDL) space, something never before possible using conventional techniques. In 2007, Milestone was granted CE Mark approval for the STA System, paving the way to begin marketing the instrument to dentists in African countries and other countries around the world that recognize the CE Mark approval process.

About Milestone Scientific Inc.

Headquartered in Livingston, New Jersey, Milestone Scientific is engaged in pioneering proprietary, highly innovative technological solutions for the medical and dental markets. Central to the Company's IP platform and product development strategy is its patented CompuFlo(R) technology for the improved and painless delivery of local anesthetic. Specifically, CompuFlo is a computer-controlled, pressure sensitive infusion, perfusion, suffusion and aspiration technology, which provides real-time readouts of pressures, fluid densities and flow rates, enabling the advanced delivery and removal of a wide array of fluids. The STA(TM) (Single Tooth Anesthesia) System computer-controlled local anesthesia delivery system which uses this technology provides dentists with audible and visual signals as to in-tissue pressure. Milestone's existing painless injection systems are currently sold in 25 countries. For more information on these and other innovative Milestone products, please visit the Company's web site found at http://www.milesci.com.

Safe Harbor Statement

This press release contains forward-looking statements regarding the timing and financial impact of the Milestone's ability to implement its business plan, expected revenues and future success. These statements involve a number of risks and uncertainties and are based on assumptions involving judgments with respect to future economic, competitive and market conditions and future business decisions, all of which are difficult or impossible to predict accurately and many of which are beyond Milestone's control. Some of the important factors that could cause actual results to differ materially from those indicated by the forward-looking statements are general economic conditions, failure to achieve expected revenue growth, changes in our operating expenses, adverse patent rulings, FDA or legal developments, competitive pressures, changes in customer and market requirements and standards, and the risk factors detailed from time to time in Milestone's periodic filings with the Securities and Exchange Commission, including without limitation, Milestone's Annual Report on Form 10-KSB for the year ended December 31, 2007. The forward looking-statements in this press release are based upon management's reasonable belief as of the date hereof. Milestone undertakes no obligation to revise or update publicly any forward-looking statements for any reason.

FOR MORE INFORMATION, PLEASE CONTACT:

Elite Financial Communications Group/Elite Media Group

Dodi Handy, President and CEO

407-585-1080 or via email at mlss@efcg.net


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SOURCE Milestone Scientific Inc.
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