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Mild-mannered metabolic helper rushes to fight invading viruses, researchers report
Date:5/7/2010

ke. Peroxisomal MAVS leads to interferon-stimulated genes while bypassing interferon secretion."

The differential response may be a way that different kinds of cells can customize their antiviral responses to the special needs of different tissues, Kagan suggests. For example, the interferon response shuts down protein synthesis, promotes inflammation, and causes a general toxic effect that some tissues may be able to handle better than others, such as the intestines.

Without interferon, peroxisomes could mount a limited response in sensitive tissues, such as nerves, eyes, or heart muscle. "We have speculated that certain tissues may only use mitochondria or only use peroxisomes," Kagan said.

"At the end of the day, we found antiviral signaling can occur from peroxisomes and from mitochondria," he said. "Only from the peroxisome do we see a rapid response, and that is sufficient to control viruses, but it cannot eliminate them. Signaling from both is needed to effectively knock them out."


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Contact: Bess Andrews
elizabeth.andrews@childrens.harvard.edu
617-919-3110
Children's Hospital Boston
Source:Eurekalert

Page: 1 2 3

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