Navigation Links
Mild increases in thyroid-stimulating hormone not harmful in the elderly
Date:9/12/2012

Chevy Chase, MDThere is no evidence to link mildly elevated thyroid-stimulating hormone (TSH) levels to an increase in mortality among the elderly, according to a recent study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM). The findings suggest that reflexively treating mild elevations of TSH in those of advanced age is unnecessary.

TSH is a sensitive, commonly measured test to check thyroid function. TSH levels are inversely related to thyroid hormone levels thyroid hormone levels below a set-point trigger an increase in TSH. Levels of TSH gradually increase during the aging process, which means that elderly patients are likely to be outside of standard reference ranges and could be labeled with the diagnosis of subclinical hypothyroidism.

"As increasing numbers of people live into their 80s and 90s, it is important to know how to manage their health, including thyroid function," said Anne R. Cappola, MD, ScM of the University of Pennsylvania in Philadelphia, and lead author of the study. "Our study shows that a gradual increase in TSH occurs during healthy aging and that mild increases in TSH are not harmful in the oldest old."

The study began in 1989-1992 and examined 5,888 men and women aged 65 and older. In 2005, 843 surviving participants who had thyroid function testing were examined for changes in physical and cognitive functions. Between 1992 and 2005, participants who were not taking thyroid medication at either visit had a 13 percent increase in TSH. Older participants (mean age 85 years) with increased TSH and subclinical hypothyroidism did not have a higher mortality rate; on the contrary, data suggested that having subclinical hypothyroidism could be protective. In addition, higher levels of thyroid hormone itself were associated with a higher risk of death.

"Our research presents the first data demonstrating longitudinal changes in thyroid function in a cohort of the oldest old," said Cappola. "Our findings suggest that treating mild elevations in TSH in the elderly is unnecessary. Further studies are needed to determine the threshold levels of thyroid function that would benefit from intervention."


'/>"/>
Contact: Aaron Lohr
alohr@endo-society.org
240-482-1380
The Endocrine Society
Source:Eurekalert

Related medicine news :

1. OSA increases cardiovascular mortality in the elderly
2. Prenatal diagnosis of congenital heart disease increases maternal stress, depression, and anxiety
3. Smoking after stroke increases death risk by 3-fold
4. Mayo, UCSF team discovers genomic variant that increases risk of brain tumors
5. Lack of food increases hospital use by HIV-infected urban poor in SF
6. Smoking during pregnancy increases the risk of wheeze and asthma in preschool children
7. Pan-fried meat increases risk of prostate cancer, new study finds
8. Pre-test genetic counseling increases cancer knowledge for BRCA patients
9. Smoking increases, while alcohol consumption may decrease risk of ALS
10. As a mans belt size increases, so does his risk of sexual and urinary dysfunction
11. Diagnostic imaging increases among stage IV cancer patients on Medicare
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... ... 2016 , ... Pixel Film Studios Released ProSlice Levels, a Media Slicing Effect ... videos a whole new perspective by using the title layers in ProSlice Levels ... , ProSlice Levels contains over 30 Different presets to choose from. FCPX ...
(Date:6/26/2016)... Birmingham, Lake Orion, Clarkston, Michigan (PRWEB) , ... ... ... their direction with respect to fertility once they have been diagnosed with endometriosis. ... for tolerable intercourse but they also require a comprehensive approach that can help ...
(Date:6/25/2016)... ... ... temporary closing of Bruton Memorial Library on June 21 due to a possible lice infestation, ... aspect of head lice: the parasite’s ability to live away from a human host, and ... necessary one in the event that lice have simply gotten out of control. , As ...
(Date:6/25/2016)... ... June 25, 2016 , ... As a lifelong Southern ... Laude and his M.D from the David Geffen School of Medicine at UCLA. He ... Los Angeles to complete his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program ...
(Date:6/25/2016)... ... ... Conventional wisdom preaches the benefits of moderation, whether it’s a matter of indulgence ... high can result in disappointment, perhaps even self-loathing. However, those who set the bar ... from PsychTests.com reveals that behind the tendency to set low expectations is ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016   Bay Area ... Network,s Dean Center for Tick Borne Illness ... and Rehabilitation, MIT Hacking Medicine, University of California, ... today announced the five finalists of Lyme ... disease.  More than 100 scientists, clinicians, researchers, entrepreneurs, ...
(Date:6/24/2016)... 2016 Dehaier Medical Systems Ltd. (NASDAQ: ... markets and sells medical devices and wearable sleep respiratory ... strategic cooperation agreement with Hongyuan Supply Chain Management Co., ... June 20, 2016, to develop Dehaier,s new Internet medical ... Dehaier will leverage Hongyuan Supply Chain,s sales platform to ...
(Date:6/24/2016)... Mass. , June 24, 2016   Pulmatrix, ... pharmaceutical company developing innovative inhaled drugs, announced today that ... Russell Investments reconstituted its comprehensive set of ... "This is an important milestone for Pulmatrix," ... will increase shareholder awareness of our progress in developing ...
Breaking Medicine Technology: