Navigation Links
Migrating stem cells possible new focus for stroke treatment
Date:5/27/2014

Two years ago, a new type of stem cell was discovered in the brain that has the capacity to form new cells. The same research group at Lund University in Sweden has now revealed that these stem cells, which are located in the outer blood vessel wall, appear to be involved in the brain reaction following a stroke.

The findings show that the cells, known as pericytes, drop out from the blood vessel, proliferate and migrate to the damaged brain area where they are converted into microglia cells, the brain's inflammatory cells.

Pericytes are known to contribute to tissue repair in a number of organs, and the researchers believe that their reparative properties could also apply to the brain. The study shows for the first time that pericytes are directly involved in the reaction of the brain tissue after stroke.

"Pericytes are a fascinating cell type with many different properties and found at high density in the brain. It was surprising that a pericyte subtype is so strongly activated after a stroke. The fact that pericytes can be converted into microglia, which have an important function in the brain after a stroke, was an unexpected finding that opens up a new possibility to influence inflammation associated with a stroke", said Gesine Paul-Visse, neurologist at Lund University and senior author of the study.

Using a green fluorescent protein bound to the pericytes, the researchers were able to track the cells' path to the damaged part of the brain. The migration takes place within a week after a stroke. When the cells reach the site of damage they are converted into microglia cells, the 'cleaners' of the central nervous system. Inflammation can, however, have both positive reparative effects and negative effects on the damaged tissue. The exact role of microglia cells in the regeneration after a stroke is not entirely clear, but we do know that pericytes play an important role in protecting the brain against disease and injury.

"We now need to elucidate how pericytes affect the brain's recovery following a stroke. Our findings put pericytes in focus as a new target for brain repair and future research will help us understand more about the brain's own defence and repair mechanisms."

There is an urgent need for new drugs that can alleviate the harmful effects of a stroke as current treatment possibilities using thrombolysis are limited to the first hours following a stroke.

"Because inflammation following a stroke is an event that continues after the acute stage, we hope that targeting pericytes in the subacute phase after stroke, i.e. within a longer time window following the onset of stroke, may influence the outcome", said Gesine Paul-Visse.


'/>"/>

Contact: Gesine Paul-Visse
Gesine.Paul-Visse@med.lu.se
46-462-220-525
Lund University
Source:Eurekalert

Related medicine news :

1. Modeling the demise of migrating brain tumor cells
2. Black Box Network Services and Phybridge Team Up to Eliminate Network Barriers for Organizations Migrating to IP Telephony and Unified Communications
3. New drug prevents spread of human prostate cancer cells
4. Tiny hitchhikers attack cancer cells
5. To prevent leukemias dreaded return, go for the stem cells
6. Scientists identify major source of cells defense against oxidative stress
7. Therapy exploits addiction of leukemia cells
8. IBN discovers human neural stem cells with tumor targeting ability
9. Leukaemia cells have a remembrance of things past
10. Small molecular bodyguards kill HPV-infected cancer cells by protecting tumor-suppressor
11. Research yields new clues to how brain cancer cells migrate and invade
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... ... for human induced pluripotent stem (iPS) cells and other difficult to transfect cells, ... Cloning Medium. The PluriQ™ G9™ Gene Editing System is a complete ...
(Date:6/24/2016)... ... June 24, 2016 , ... Finally, a bruise cream ... procedures, dermaka cream can be incorporated into the post-surgical treatment plans of a variety ... , dermaka cream is very effective for bruising and causes a rapid resolution ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... Randall Markarian, DDS, are co-chairs for the Illinois State Dental Society (ISDS) Foundation’s ... 15-16 at the Gateway Convention Center in Collinsville. , They expect ...
(Date:6/24/2016)... ... June 24, 2016 , ... SpiritQuest Sedona Retreats, located in ... Sedona, surrounded by famous vortex sites: Cathedral Rock, Airport Mesa, and Boynton Canyon. The ... the Lodge at Sedona as well as the Sedona Rouge, both popular accommodations for ...
(Date:6/23/2016)... ... June 23, 2016 , ... Terumo BCT, a global ... for clinical transfusion research programs and for the blood supply in the Netherlands, ... Predictive Analytical Rating Score (PREPAReS) study. , Currently in its sixth year, ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... The vast majority of dialysis patients currently ... are usually 3 times a week, with treatment times ... time, equipment preparation and wait time.  This regimen can ... patients who are elderly and frail.  Many elderly dialysis ... centers for some duration of time. Residents ...
(Date:6/23/2016)... NEW YORK , June 23, 2016 ... rough waters, but it continues to present great opportunities ... featured companies for today: Intrexon Corp. (NYSE: ... ), Arena Pharmaceuticals Inc. (NASDAQ: ARNA ), ... Learn more about these stocks and receive your complimentary ...
(Date:6/23/2016)... -- Delcath Systems, Inc. (NASDAQ: DCTH ), a ... of primary and metastatic liver cancers, announces that the ... www.againsttheodds.eu - has been awarded a silver medal ... The website was developed as an education ... who are coping with the devastating diagnosis of cancer ...
Breaking Medicine Technology: