Navigation Links
Migrating stem cells possible new focus for stroke treatment
Date:5/27/2014

Two years ago, a new type of stem cell was discovered in the brain that has the capacity to form new cells. The same research group at Lund University in Sweden has now revealed that these stem cells, which are located in the outer blood vessel wall, appear to be involved in the brain reaction following a stroke.

The findings show that the cells, known as pericytes, drop out from the blood vessel, proliferate and migrate to the damaged brain area where they are converted into microglia cells, the brain's inflammatory cells.

Pericytes are known to contribute to tissue repair in a number of organs, and the researchers believe that their reparative properties could also apply to the brain. The study shows for the first time that pericytes are directly involved in the reaction of the brain tissue after stroke.

"Pericytes are a fascinating cell type with many different properties and found at high density in the brain. It was surprising that a pericyte subtype is so strongly activated after a stroke. The fact that pericytes can be converted into microglia, which have an important function in the brain after a stroke, was an unexpected finding that opens up a new possibility to influence inflammation associated with a stroke", said Gesine Paul-Visse, neurologist at Lund University and senior author of the study.

Using a green fluorescent protein bound to the pericytes, the researchers were able to track the cells' path to the damaged part of the brain. The migration takes place within a week after a stroke. When the cells reach the site of damage they are converted into microglia cells, the 'cleaners' of the central nervous system. Inflammation can, however, have both positive reparative effects and negative effects on the damaged tissue. The exact role of microglia cells in the regeneration after a stroke is not entirely clear, but we do know that pericytes play an important role in protecting the brain against disease and injury.

"We now need to elucidate how pericytes affect the brain's recovery following a stroke. Our findings put pericytes in focus as a new target for brain repair and future research will help us understand more about the brain's own defence and repair mechanisms."

There is an urgent need for new drugs that can alleviate the harmful effects of a stroke as current treatment possibilities using thrombolysis are limited to the first hours following a stroke.

"Because inflammation following a stroke is an event that continues after the acute stage, we hope that targeting pericytes in the subacute phase after stroke, i.e. within a longer time window following the onset of stroke, may influence the outcome", said Gesine Paul-Visse.


'/>"/>

Contact: Gesine Paul-Visse
Gesine.Paul-Visse@med.lu.se
46-462-220-525
Lund University
Source:Eurekalert

Related medicine news :

1. Modeling the demise of migrating brain tumor cells
2. Black Box Network Services and Phybridge Team Up to Eliminate Network Barriers for Organizations Migrating to IP Telephony and Unified Communications
3. New drug prevents spread of human prostate cancer cells
4. Tiny hitchhikers attack cancer cells
5. To prevent leukemias dreaded return, go for the stem cells
6. Scientists identify major source of cells defense against oxidative stress
7. Therapy exploits addiction of leukemia cells
8. IBN discovers human neural stem cells with tumor targeting ability
9. Leukaemia cells have a remembrance of things past
10. Small molecular bodyguards kill HPV-infected cancer cells by protecting tumor-suppressor
11. Research yields new clues to how brain cancer cells migrate and invade
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/19/2017)... ... ... Yesterday, the President of the United States retracted his condemnation of white ... two sides to hatred, bigotry, discrimination, and a white supremacy nationalist agenda. That ... all forms of such hatred and discrimination in this country and globally. ...
(Date:8/19/2017)... ... August 19, 2017 , ... ... joined its Orlando location as an interventional pain management physician. He brings a ... the treatment of migraine headaches, and significant experience in spinal cord stimulation for ...
(Date:8/18/2017)... ... August 19, 2017 , ... ... Thailand presided over the Amazing Thailand Health and Wellness Tourism Showcase 2017 yesterday, ... Noppadon Pakprot, Deputy Governor for Tourism Products and Business at TAT said, “Thailand ...
(Date:8/18/2017)... ... August 18, ... ... For Immediate Release                Contact: Julian Teixeira, August 18, 2017                    202-478-8564 ... and Relationship Advice from their Fathers , Contrary to ...
(Date:8/18/2017)... ... August 18, 2017 , ... ... campaign, advocating for active, healthy lifestyles and highlighting the importance of proactive eye ... hearing impairments and shares the latest innovations in hearing aid technology. , ...
Breaking Medicine News(10 mins):
(Date:8/2/2017)... AURORA, Ore. , Aug. 2, 2017  Life Flight ... Call Agreement. The agreement improves patient care and operational efficiency ... Springfield , Cottage Grove ... ICU level medical transportation. PeaceHealth and Life Flight Network work ... care available during transport, or when a time sensitive emergency ...
(Date:8/1/2017)... , Aug. 1, 2017   CerSci Therapeutics ... Dallas, Texas , has received notice from ... National Institutes of Health (NIH) that it has been ... grant totaling over $650,000 in 2017 with an additional ... CerSci,s Investigational New Drug application of their lead non-opioid ...
(Date:7/31/2017)... Tru-D SmartUVC robots have arrived at Brian Allgood Army Community ... for "Total Room Ultraviolet Disinfection," is a 5-foot-5 germ-killing robot that is ... cleans the area with traditional cleaning protocols. ... Tru-D fights germs at Army hospitals ... "Although the BAACH has a very low infection rate, below national ...
Breaking Medicine Technology: