Navigation Links
Migraines associated with lower risk of breast cancer
Date:11/5/2008

SEATTLE Women who suffer from migraines may take at least some comfort in a recent, first-of-its-kind study that suggests a history of such headaches is associated with a significantly lower risk of breast cancer. Christopher I. Li, M.D., Ph.D., and colleagues at Fred Hutchinson Cancer Research Center report these findings in the November issue of Cancer Epidemiology, Biomarkers and Prevention.

"We found that, overall, women who had a history of migraines had a 30 percent lower risk of breast cancer compared to women who did not have a history of such headaches," said Li, a breast-cancer epidemiologist and associate member of the Hutchinson Center's Public Health Sciences Division.

In particular, migraine history appeared to reduce the risk of the most common subtypes of breast cancer: those that are estrogen-receptor and/or progesterone-receptor positive. Such tumors have estrogen and/or progesterone receptors, or docking sites, on the surface of their cells, which makes them more responsive to hormone-blocking drugs than tumors that lack such receptors.

The biological mechanism behind the association between migraines and breast cancer is not fully known, but Li and colleagues suspect that it has to do with fluctuations in levels of circulating hormones.

"Migraines seem to have a hormonal component in that they occur more frequently in women than in men, and some of their known triggers are associated with hormones," Li said. "For example, women who take oral contraceptives three weeks of active pills and one week of inactive pills to trigger menstruation tend to suffer more migraines during their hormone-free week," he said. Conversely, pregnancy a high-estrogen state is associated with a significant decrease in migraines. "By the third trimester of pregnancy, 80 percent of migraine sufferers do not have these episodes," he said. Estrogen is known to stimulate the growth of hormonally sensitive breast cancer.

While this study represents the first of its kind to look at a potential connection between migraines and breast cancer, Li and colleagues have data from two other studies that in preliminary analyses appear to confirm these findings, he said.

"While these results need to be interpreted with caution, they point to a possible new factor that may be related to breast-cancer risk. This gives us a new avenue to explore the biology behind risk reduction. Hopefully this could help stimulate other ideas and extend what we know about the biology of the disease."

For the study, the researchers combined data from two population-based, case-control studies of 3,412 Seattle-area postmenopausal women, 1,938 of whom had been diagnosed with breast cancer and 1,474 of whom had no history of breast cancer, who served as a comparison group. Information on migraine history was based on self-report and was limited to migraines that had been diagnosed by a physician or other health professional.


'/>"/>

Contact: Kristen Lidke Woodward
kwoodwar@fhcrc.org
206-667-5095
Fred Hutchinson Cancer Research Center
Source:Eurekalert

Related medicine news :

1. Migraines Frequency Influences Heart Attack, Stroke Risk
2. Epilepsy Drug Doesnt Prevent Migraines
3. Comatose locusts may help relieve migraines
4. Neuromuscular Dentistry Ends Womans Migraines
5. NIAID media availability: Seizures following parasitic infection associated with brain swelling
6. Caffeine in Pregnancy Associated With Low Birth Weight Risk
7. While prevalent, sexual problems in women not always associated with distress
8. Statin use associated with reduction in prostate specific antigen levels
9. Nation's Top Healthcare Organizations Announce Strategies to Prevent Deadly Healthcare-Associated Infections : Strategies emphasize practical implementation in acute healthcare settings
10. AHRQ Awards $3 Million to Help Reduce Central Line-Associated Bloodstream Infections in Hospital ICUs
11. Michigan Success Lands National Research Contract to Reduce Hospital-Associated Infections in 10 States
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... ... ... PawPaws brand pet supplements owned by Whole Health Supply is ... of felines. The formula is all-natural and is made from Chinese herbs that have ... Kidney Support Supplement Soft Chews are Astragalus Root Extract and Rehmannia Root Extract ...
(Date:6/25/2016)... ... June 25, 2016 , ... ... and applications at AcademyHealth’s Annual Research Meeting June 26-28, 2016, at the Hynes ... important health care topics including advance care planning, healthcare costs and patient and ...
(Date:6/25/2016)... ... June 25, 2016 , ... "With 30 hand-drawn hand gesture animations, FCPX users ... - CEO of Pixel Film Studios. , ProHand Cartoon’s package transforms over 1,300 ... Pro X . Simply select a ProHand generator and drag it above media or ...
(Date:6/25/2016)... ... June 25, 2016 , ... Dr. Calvin Johnson ... Recently, he has implemented orthobiologic procedures as a method for treating his patients. ... the first doctors to perform the treatment. Orthobiologics are substances that orthopaedic surgeons ...
(Date:6/24/2016)... ... June 24, 2016 , ... A recent article ... are unfamiliar with. The article goes on to state that individuals are now more ... these less common operations such as calf and cheek reduction. The Los Angeles area ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... Calif. , June 24, 2016  American Respiratory Labs (ARL), ... is now able to perform sophisticated lung assessments in patients, homes, ... , Inc. Patients are no longer limited to ... EasyOne PRO ® , ARL patients like Jeanne R. of ... in the comfort of her own home. ...
(Date:6/24/2016)... Belgium , June 24, 2016 ... the appointment of Dr. Edward Futcher ... Non-Executive Director, effective June 23, 2016.Dr. Futcher was ... Nominations and Governance Committees.  As a non-executive member ... independent expertise and strategic counsel to VolitionRx in ...
(Date:6/23/2016)... BEVERLY HILLS, Calif. , June 23, 2016 ... faced the many challenges of the current process. Many of ... option because of the technical difficulties and high laboratory costs ... would have to offer it at such a high cost ... to afford it. Dr. Parsa Zadeh , ...
Breaking Medicine Technology: